Isolation, Characterization and Antiplasmodial Activity of Steroidal Alkaloids from Funtumia elastica (Preuss) Stapf.

Abstract

Alkaloids U 0600Isolation, Characterization and Antiplasmodial Activity of Steroidal Alkaloids from Funtumia elastica (Preuss) Stapf. -Four compounds (I) are extracted from the title plants' bark, which are identified as the active constituents against the chloroquine-resistant strain FcB1 of P. falciparum. -(ZIRIHI, G. N.; GRELLIER, P.; GUEDE-GUINA, F.; BODO, B.; MAMBU*, L.; Bioorg. Med. Chem. Lett. 15 (2005) 10, 2637-2640; Dep. Regul., Dev. Diversite Mol., CNRS, Mus. Natl. Hist. Nat., F-75231 Paris, Fr.; Eng.) -C. Oppel 40-190

Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships

“…Further bioactivity-guided chromatographic fractionation led to obtain five alkaloids, which were identified as conessine (1), isoconessimine (2), conessimin (3), conarrhimin (4) and conimin (5) (Fig. 1) by spectroscopic analyses, including ESI-MS and NMR ( 1 H and 13 C NMR: see Tables 1 and 2, respectively), and in comparison with published data (Zirihi et al, 2005;Tran et al, 2006). The AChE inhibitory activity of these compounds was tested by the Ellman's method in 96-well microplates.…”

Antimicrobial and anti-inflammatory properties ofFuntumia elastica

“…The antimicrobial activity exhibited by F. elastica extracts may be responsible for its use as agent for the treatment of wounds and veneral diseases such as syphilis and gonorrhea. In fact, conessine, a steroid alkaloid found in F. elastica, could possibly account for its strong antibacterial properties (Zirihi et al, 2005;Sonibare et al, 2009). The MICs of the FLE extract against the test organisms were found to be lower than that of FBE extract.…”

“…The anti-inflammatory property observed for F. elastica bark extract could be due to the steroids such as cyclofuntumienol and cycloeucalenol present in the leaves and stem bark (Zirihi et al, 2005). Phytosterols have iscosmodulating effects, normalizing an over-reactive antibody response as well as anti-inflammatory properties.…”

“…(Apocynaceae), known commonly as silkrubber (local Asante-Twi name is "Frumtum/Ofruntum"), is traditionally used to treat whooping cough (Burkill, 1995), inflammatory diseases such as asthma, blennorhea, and painful menstruation (Olaniyi, 1989), cutaneous fungal infections, hemorrhoids, syphilis, gonorrhea (Odugbemi, 2006;Burkill, 1995) and wounds (Adekunle & Ikumapayi, 2006). Some steroidal alkaloids (holarrhetine, conessine, holarrhesine and isoconessimine) have been isolated from the stem bark and conanine group, namely, irehdiamine A and D, irehamine, conkuchine and irehine from leaves of F. elastica (Zirihi et al, 2005). This study investigated the antimicrobial and anti-inflammatory activities of ethanol stem bark and leaf extracts of F. elastica based on its ethnobotanical uses.…”

The radical-polar crossover annulation approach to chiral substituted pyrrolidines and piperidines

“…2 The less known steroidal alkaloids 3-8 depicted in Figure 1 were isolated from the stem bark of Funtumia elastica, and showed antiplasmodial activity. 3 (+)-Preussin (9), the antifungal agent isolated from fermentations of Aspergillus ochraceus, showed a broad range of activity against filamentous fungi and yeast species. 4,5 Finally, cytotoxic activity against a skin cancer cell line was demonstrated by two alkaloids, gelsedine (10) and gelsemicine (11), isolated from Gelsemium elegans and G. sempervirens, respectively.…”