Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of<i>Dichapetalum filicaule</i>

Chama, Mary Anti; Dziwornu, Godwin Akpeko; Waibel, Reiner; Osei‐Safo, Dorcas; Addae‐Mensah, Ivan; Otchere, Joseph; Wilson, Michael D.

doi:10.3109/13880209.2015.1059861

Cited by 19 publications

(42 citation statements)

References 38 publications

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“…Chemical constituents of Dichapetalum filicaule were isolated and tested for anthelmintic activity on a Necator americanus egg hatch inhibition assay. Three compounds (including a new dichapetalin) were found to be active: dichapetalin X, dichapetalin A and glycerol monostearate [71].…”

Section: Natural Products Active Against Intestinal Parasitic Nematodesmentioning

confidence: 99%

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

2020

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Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem. Thus, there is an urgent need for the discovery and development of new anthelmintic drugs, especially ones with novel mechanisms of action. Medicinal plants hold great promise as a source of effective treatments, including anthelmintic therapy. They have been used traditionally for centuries and are mostly safe (if not, their toxicity is well-known). However, in most medicinal plants the compounds active against nematodes have not been identified thus far. The free-living nematode C. elegans was demonstrated to be an excellent model system for the discovery of new anthelmintics and for characterizing their mechanism of action or resistance. The compounds discussed in this review are of botanical origin and were published since 2002. Most of them need further studies of their toxicity, mechanisms and structure-activity relationship to assess more fully their potential as drugs.

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Section: Natural Products Active Against Intestinal Parasitic Nematodesmentioning

confidence: 99%

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

2020

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“…1D-NMR data coulped with 2D-NMR data (HSQC and HMBC) of 6 corresponded to a well-known triterpenoid, namely pomolic acid. [20][21][22] 1D-NMR revealed that compound 6 contained five methyl, one methine carbinol, one olefinic bond, one carbonyl carbon, and remaining aliphatic methines and methylenes. Hydroxygenation occurred at carbon carbinol C-3 (δ C 80.1) with the key HMBC correlations H-1, H-23, and H-24/C-3.…”

Section: Extraction and Isolationmentioning

confidence: 99%

Chemical constituents from the leaves of Styrax annamensis Guill

Tra

Anh

Cường³

et al. 2020

Vietnam Journal of Chemistry

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A phytochemical study of the ethyl acetate extract (EtOAc) of Styrax annamensis leaves resulted in the isolation and determination of six known compounds, including three nor‐neolignans type 2‐phenylbenzofurans egonol (1), egonoic acid (2) and (–)‐machicendiol (3), two lignans styraxin (4) and vladinol D (5), and a triterpenoid pomolic acid (6). The chemical structures of these compounds were determined by NMR spectroscopies, and MS data. This is the first time to isolate these compounds from S. annamensis species. Compounds 3 and 5 have also been observed from genus Styrax for the first time.

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“…[8][9][10] Bioactive dichapetalins and several other compounds have been isolated from Dichapetalum species. [11][12][13][14][15][16] Dichapetalum gelonioides (Roxb.) Engl (Figure 1) is a large shrub or small tree with pubescent branchlets and found distributed in evergreen and semi-evergreen forests as forest undergrowth.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, antifungal and antioxidant activity of Dichapetalum gelonioides (Roxb.) Engl. (Dichapetalaceae)

Priyanka¹,

Bharadwaj²,

Sachin³

et al. 2018

J. Drug Delivery Ther.

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Objectives: Dichapetalum gelonioides (Roxb.) Engl. belongs to the family Dichapetalaceae. In the present study, we investigated antibacterial, antifungal and antioxidant activity of methanolic extract of leaf and fruit of D. gelonioides. Methods: Maceration process was carried out for extraction of leaf and fruit of D. gelonioides. Agar well diffusion method was employed to evaluate antibacterial activity of extracts against gram positive and gram negative bacteria. Poisoned food technique was performed to investigate antifungal activity of extracts against two seed-borne fungi. Antioxidant activity was evaluated by DPPH radical scavenging and ferric reducing assays. Results: Both leaf and fruit extracts were effective in causing inhibition of all test bacteria. Highest and least inhibitory activity was observed against Bacillus cereus and Escherichia coli respectively. Both Aspergillus niger and Bipolaris sp. were inhibited to >50% by leaf and fruit extracts. Extent of inhibition of Bipolaris sp. was slightly higher when compared to A. niger. Both leaf and fruit extracts showed a dose dependent scavenging of DPPH radicals with high activity being showed by leaf extract. Leaf extract was shown to exhibit marked reducing potential than fruit extract. Conclusions: Overall, leaf extract was shown to be more effective in displaying antioxidant activity and causing inhibition of bacteria and fungi when compared to fruit extract. The results indicate that the plant possess active principles which are to be purified, characterized and subjected for antimicrobial and antioxidant assays in further studies.

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Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents ofDichapetalum filicaule

Abstract: This is the first report of the phytochemical investigation of D. filicaule. The study has yielded a new dichapetalin and also demonstrated the potential anthelminthic properties of the constituents.

Cited by 19 publications

References 38 publications

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

Chemical constituents from the leaves of Styrax annamensis Guill

Antibacterial, antifungal and antioxidant activity of Dichapetalum gelonioides (Roxb.) Engl. (Dichapetalaceae)

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