ISOLATION AND SYNTHESIS OF A NEW STEROL FROM RAT FECES<sup>1,2</sup>

Wells, William W.; Neiderhiser, Dewey H.

doi:10.1021/ja01581a065

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1961

2010

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Cited by 27 publications

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“…'. Da es keine Anhaltspunkte fur die Reihenfolge der Umwandlungen gab und die Zwischenprodukte vermutlich nur in Spuren auftreten, verwendeten wir die Puls-Technik der radioaktiven Markierung, um neue Stoffwech-3p-01 (Methostenol oder Lophenol) aus tierischen [65] oder pflanzlichen [66] Quellen und 4a-Methyl-Akholestenol aus Tumorgewebe [67]…”

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Die Biosynthese des Cholesterins. Nobel‐Vortrag am 11. Dezember 1964

Bloch

1965

Angewandte Chemie

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Die Biosynthese des Cholesterins. Nobel‐Vortrag am 11. Dezember 1964

Bloch

1965

Angewandte Chemie

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Kuhn‐Roth Oxidation

2010

Comprehensive Organic Name Reactions and Reagents

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The method for quantifying the number of methyl groups attached to the carbon atom in an organic molecule, which involves the oxidation of such an organic compound with chromic acid in the presence of sulfuric acid, followed by steam distillation to collect the generated acetic acid and quantification of the acetic acid via acid/base titration. In addition, the collected acetic acid can be further analyzed by conversion of acetic acid into iodoform by hypoiodite. Therefore, this reaction is generally known as the Kuhn–Roth C‐methyl determination. The study finds that depending on the nature of the organic molecules, the ratio of chromic acid and sulfuric acid varies. Besides determining the number of methyl groups, this method can also measure the number of ethyl groups on the cyclic compounds. Several limitations of this reaction have been discussed. This method has been extensively used in the structural elucidation of natural products.

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