Isolation and structural characterization of bioactive compound from Aristolochia sprucei aqueous extract with anti-myotoxic activity

The Need for Next-Generation Antivenom for Snakebite Envenomation in India

“…Considering the vast opportunities plant products offer, in silico studies using molecular docking could be employed to identify the bioactive components that help bind to the active site of the toxins in snake venom and study their interaction mechanisms. This could help in designing modified plant compounds with better binding ability and hence improved neutralization potential [165,166].…”

Efficient separation of aristolochic acid I from Caulis aristolochiae manshuriensis (Guan-mu-tong) with copper mediated magnetic molecularly imprinted polymer

“…S1†) is not an ideal template molecule for MIPs, which possess neither a steric structure nor multiple functional groups. 13,29…”

“…Solvent extraction (such as impregnation and percolation) is the most conventional technique. [12][13][14][15] However, it does not match the requirements of modern manufacture owing to its intrinsic aws, such as labor-intensive and time and organic solvent consuming. 16,17 Subsequently, many separation techniques have been developed, such as supercritical extraction, 18 microwave-assisted extraction, 19 ultrasonic-assisted extraction, 20 phase extraction (SPE).…”

“…S1 †) is not an ideal template molecule for MIPs, which possess neither a steric structure nor multiple functional groups. 13,29 Fortunately, metal mediated MIPs can overcome the abovementioned aws to some extent, especially for the non-ideal templates. Such an improvement can be ascribed to the existence of metal ions and the introduction of coordination both in the preparation and recognition procedures.…”