Isolation and primary structure of human peptide YY

Tatemoto, Kazuhiko; Nakano, Itsuro; Makk, George; Angwin, Pamela; Mann, Michael J.; Schilling, James; Go, Vay Liang W.

doi:10.1016/s0006-291x(88)80308-5

Cited by 39 publications

(6 citation statements)

References 5 publications

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“…Peptide YY (PYY) is synthesized in the body as a 36-amino acid peptide (PYY 1-36 ) [185]. After being released, dipeptidyl peptidase IV (DPP-IV) cleaves the N-terminal tyrosine-proline residues to form PYY 3-36 [186].…”

Section: Peptide Yymentioning

confidence: 99%

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

et al. 2009

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Cholecystokinin (CCK) is a peptide hormone that is released from the gut in response to nutrients such as lipids to lower food intake. Here we report that a primary increase of CCK-8, the biologically active form of CCK, in the duodenum lowers glucose production independent of changes in circulating insulin levels. Furthermore, we show that duodenal CCK-8 requires the activation of the gut CCK-A receptor and a gut-brain-liver neuronal axis to lower glucose production. Finally, duodenal CCK-8 fails to lower glucose production in the early onset of high-fat diet-induced insulin resistance. These findings reveal a role for gut CCK that lowers glucose production through a neuronal network and suggest that intestinal CCK resistance may contribute to hyperglycemia in response to high-fat feeding.

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Section: Peptide Yymentioning

confidence: 99%

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

et al. 2009

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“…It is produced and secreted by the enteroendocrine L-cells, and it is released in response to stimulation of the L-cell by luminal nutrients [27,28]. Lipid is a potent stimulator of PYY release into the circulation from the gut relative to other macronutrients [29].…”

Section: Peptide Yymentioning

confidence: 99%

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

Melvin

Roux

Docherty

2016

Curr Atheroscler Rep

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In addition to the role of gut hormones in the regulation of energy homeostasis, our understanding of the potential influence of enteroendocrine peptides in food reward pathways is evolving. So too is the role of gut derived hormones on energy expenditure. Gut-derived hormones have the ability to alter feeding behavior. Certain obesity therapies already manipulate this system; however, our evolving understanding of the effects of enteroendocrine signals on hedonic aspects of feeding and energy expenditure may be crucial in identifying future obesity therapies.

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“…One such hormone appears to be involved, peptide YY. In the human this hormone is found predominantly in the colon and terminal ileum (Tatemoto et al 1988), and has been shown to inhibit intestinal secretion in animal in vitro and in vivo models (Okuno et af. 1992; Bilchik et al 1993).…”

Section: Possible Mechanisms Of T H E C O L O N I C Response To E N Tmentioning

confidence: 99%

Enteral-feeding-related diarrhoea: proposed causes and possible solutions

Bowling

1995

Proc. Nutr. Soc.

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Isolation and primary structure of human peptide YY

Cited by 39 publications

References 5 publications

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

Intestinal Cholecystokinin Controls Glucose Production through a Neuronal Network

The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight

Enteral-feeding-related diarrhoea: proposed causes and possible solutions

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