Isolation and Pharmacological Investigation of Compounds From <i>Euphorbia matabelensis</i>

Hammadi, Reham; Kúsz, Norbert; Mwangi, Peter Waweru; Kulmány, Ágnes; Zupkó, István; Orvos, Péter; Tálosi, László; Hohmann, Judit; Vasas, Andrea

doi:10.1177/1934578x19863509

Cited by 5 publications

(7 citation statements)

References 23 publications

(40 reference statements)

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“…In 13 C NMR and DEPT experiments were observed 15 carbons signals, including one methylene carbon, six methynics carbons, and eight quaternary carbons. With this data and comparing with previously reported in the literature, compound 6 was identified as 5,7,3',4'-tetrahidroxyflavanone, known as eriodyctiol [29] (Figure 5). This flavonoid was not reported before in this species.…”

Section: Ethyl Acetate Sub-extract Compositionsupporting

confidence: 72%

“…FIIB fraction (5.2 mg) was subjected to flash chromatography, eluted with chloroform/methanol mixtures, yielding three sub-fractions (SFIIB1-SFIIB3), of which the sub-fraction SFIIB3 led to obtaining of 6 in pure form (3.5 mg, 67.0%). Compound 6 was identified as eriodictyol by NMR spectrometry, by comparison of their spectroscopic data with the literature [29].…”

Section: Extraction and Isolationmentioning

confidence: 99%

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Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Siben

Castro

Faraoni

2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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Polyphenols are attracting increasing attention to the discovery of useful agents for the treatment of neurodegenerative diseases. Thelesperma megapotamicum (Spreng.) Kuntze belongs to the family Asteraceae which is known to have a high antioxidant capacity. The phytochemical investigation of T. megapotamicum revealed the presence of 1'-S-isobutyroxyeugenol isobutyrate (1), lupeol (2), 1'-S-acetoxyeugenol isobutyrate (3), stigmasterol (4), -sitosterol (5), eriodictyol (6), luteolin (7), and marein (8), as major secondary metabolites. The neuroprotective activity of this species was studied by evaluating the inhibition in vitro of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and the antioxidant capacity of the sub-extracts and of the major metabolites isolated from them. The AChE and BChE inhibition were determined by Ellman's method and the antioxidant activity by DPPH assay. The inhibitory activity against BChE and the antioxidant capacity of the polyphenols present in T. megapotamicum highlight this species as a promising source of active metabolites for the development of agents for the treatment of neurodegenerative diseases.

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Section: Ethyl Acetate Sub-extract Compositionsupporting

confidence: 72%

Section: Extraction and Isolationmentioning

confidence: 99%

Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Siben

Castro

Faraoni

2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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“…Its blocking activity on GIRK channels was reported to be weak with inhibition of 12.18% ± 1.39 for eriodictyol (82) and 13.50% ± 2.69 for naringenin (83), at 10.00 µM. Despite the negative effect, these compounds possess promising anti-inflammatory, antiallergenic, antimicrobial, and antioxidant properties [77,84,[91][92][93].…”

Section: Biological Studies Structure-activity Relationship and Therapeutic Potential 61 Cytotoxic Studiesmentioning

confidence: 99%

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

et al. 2021

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Plants of the genus Euphorbia are widely distributed across temperate, tropical and subtropical regions of South America, Asia and Africa with established Ayurvedic, Chinese and Malay ethnomedical records. The present review reports the isolation, occurrence, phytochemistry, biological properties, therapeutic potential and structure–activity relationship of Euphorbia flavonoids for the period covering 2000–2020, while identifying potential areas for future studies aimed at development of new therapeutic agents from these plants. The findings suggest that the extracts and isolated flavonoids possess anticancer, antiproliferative, antimalarial, antibacterial, anti-venom, anti-inflammatory, anti-hepatitis and antioxidant properties and have different mechanisms of action against cancer cells. Of the investigated species, over 80 different types of flavonoids have been isolated to date. Most of the isolated flavonoids were flavonols and comprised simple O-substitution patterns, C-methylation and prenylation. Others had a glycoside, glycosidic linkages and a carbohydrate attached at either C-3 or C-7, and were designated as d-glucose, l-rhamnose or glucorhamnose. The structure–activity relationship studies showed that methylation of the hydroxyl groups on C-3 or C-7 reduces the activities while glycosylation loses the activity and that the parent skeletal structure is essential in retaining the activity. These constituents can therefore offer potential alternative scaffolds towards development of new Euphorbia-based therapeutic agents.

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“…6, scheme 3) which is known as sapintoxin D [13] and its isomers. While peaks 21, 24 and 51 eluted at Rt, 15.63, 16.08, 28.58 min were identified as phorbol-12, 13-didecanoate and its isomers from MS 1 and MS 2 spectral data (Table 1). Prominent MS 1…”

Section: Phorbol Diestersmentioning

confidence: 99%

“…The genus Euphorbia is one of the largest genera with more than 2000 species worldwide [1]. Euphorbia species are characterized by the presence of a vast array of macrocyclic diterpenoids with various types of carbon skeletons.…”

Section: Introductionmentioning

confidence: 99%

Diterpenoids Profile of E. Paralias and E. Geniculate Using Uplc-Esi/MS Spectrometry

Hassan

Ghani

eltomy³

et al. 2020

Egypt. J. Chem.

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Euphorbia species contain series of macrocyclic diterpenoids which present as mono, di and sometimes triesters and were reported to possess several and diverse biological activities. The aim herein was to use the ultra-performance coupled to the positive ion mode electron spray ionization mass spectroscopy (UPLC-ESI-MS) as an analytical tool for rapid screening and tentative identification of diterpenoids in the methylene chloride fractions of Euphorbia paralias and Euphorbia geniculata. The identification of compounds was based on ESI-MS and ESI-MS/MS fragmentation pattern, in addition to comparison with reported literature. Five classes were determined including tigliane, ingenane, lathyrane, daphnane and jatrophane diterpenoids esters. Each class of the detected diterpenoids obtained its characteristic ESI-MS/MS fragmentation which facilitates its identification. As a result, a total of fifty-two diterpenoids were identified and characterized in Euphorbia paralias and Euphorbia geniculata. All of these compounds are first report in the two plants by this method. Peak 35 was tentatively identified as ingenol-20-hydroxyheptanoate which expected to be a new compound. The results demonstrated that the used method could be a rapid, and an effective analytical tool for screening and characterization of diterpenoids in the complex systems of plant extracts.

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Isolation and Pharmacological Investigation of Compounds From Euphorbia matabelensis

Cited by 5 publications

References 23 publications

Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Polyphenols from Thelesperma megapotamicum and Their Antioxidant and Neuroprotective Activities

Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure–Activity Relationships

Diterpenoids Profile of E. Paralias and E. Geniculate Using Uplc-Esi/MS Spectrometry

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