Isolation and molecular characterization of bioactive secondary metabolites from Callyspongia spp. associated fungi

Meenupriya, J.; Thangaraj, M.

doi:10.1016/s1995-7645(10)60177-0

Cited by 16 publications

(10 citation statements)

References 15 publications

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“…A review by Blunt et al (2012) reported that 296 new compounds from marine sponges were isolated only in 2011. But over the past decade, a consensus has developed among experts that these novel natural products from sponge extracts are synthesised, either in part or in entirely, by the symbiotic microbes that are intimately associated with these marine metazoans (Konig et al 2006;Meenupriya and Thangaraj 2010). These microbes are thought to be involved in a variety of ecological functions including production of secondary metabolites that can contribute to their own ecological success and to that of their host .…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al 2008;Caballero-George et al 2010;Paz et al 2010;Zhou et al 2011;Thirunavukkarasu et al 2012;Flemer 2013;Henriquez et al 2013;Bolaños et al 2015). In Asia, there have been published information on the diversity of sponge-associated fungi in countries like China (Zhang et al 2009;Liu et al 2010;Ding et al 2011;Zhou et al 2011;Yu et al 2012;He et al 2014;Jin et al 2014), India (Meenupriya and Thangaraj 2010;Thirunavukkarasu et al 2012) Indonesia (Namikoshi et al 2002), Israel , Malaysia (Mahyudin 2008) and Russia ). To date, there are no ecological studies of sponge-associated fungi or any information about the species richness and fungal biodiversity of sponges in the marine environment of the Philippines.…”

Section: Introductionmentioning

confidence: 99%

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Fungal diversity of mangrove-associated sponges from New Washington, Aklan, Philippines

Calabon

Sadaba

2018

Mycology

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Sponge-associated fungi are the least explored marine fungal groups. It is only in recent years that fungal symbionts of marine sponges have received attention mainly due to the isolation of bioactive metabolites while not much attention was given to their specificity, biogeography and exact roles in marine sponges. The diversity of fungi associated with mangrove sponges ( Axinella sp., Halichondria cf. panicea, Haliclona sp., Tedania sp.) collected from New Washington, Aklan, Philippines were investigated using morphological observation. A total of 110 species of sponge-associated fungi belonging to 22 genera of ascomycetes with 18 genera of asexual morphs whose sexual stage is unknown, 2 genera of basidiomycetes, 21 morphospecies of Mycelia sterilia , 1 unidentified yeast species and 11 unidentified hyphomycetes were isolated from four species of mangrove sponges. This is the first study that explored the diversity and ecology of sponge-associated fungi in mangrove habitats from the Philippines. The results of the study suggest host-preference by various fungal taxa and the development of fungi on these hosts appeared to be strongly influenced by the characteristics or nature of the immediate environment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fungal diversity of mangrove-associated sponges from New Washington, Aklan, Philippines

Calabon

Sadaba

2018

Mycology

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“…This paper reports the isolation of three bioactive compounds from A. ochraceus. The antimicrobial activities of the isolated pure compounds in ethyl acetate solvent were reported since ethyl acetate extract showed promising results in Aspergillus flavus [31] . The isolated compounds showed significant antimicrobial activity against potential human pathogens.…”

Section: Discussionmentioning

confidence: 99%

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Meenupriya

Thangaraj

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Previous studies showed that Callyspongia sp. contains triterpenoid, steroid, alkaloid, and flavonoid [4][5][6]. Flavonoid and terpenoid contained in Callyspongia sp.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of Marine Sponge Callyspongia Sp. And Its Acute Toxicity

Fristiohady¹,

Wahyuni²,

Malik³

et al. 2019

Asian J Pharm Clin Res

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Objective: This study aims to investigate the anti-inflammatory effect of the ethanolic extract of Callyspongia sp. using stabilization of the human red blood cell (HRBC) membrane method and its acute toxicity using brine shrimp lethality test (BSLT) method. Methods: Callyspongia sp. was macerated with 96% ethanol. Extract characterized and screened for the secondary metabolite. Anti-inflammatory activity by stabilization of the HRBC membrane method with a varied dose of 50 ppm; 100 ppm; 200 ppm; 400 ppm; 800 ppm; 1600 ppm; and 3200 ppm. Solutions observed using a photometer to describing stability and ability in preventing membranes hemolytic and statistically analyzed using SPSS. Acute toxicity carried out by the BSLT method and analyzed using Minitab®ver. 17.2.1. Results: The phytochemical screening was indicating that Callyspongia sp. contains flavonoid, alkaloid, and terpenoid. The results of the anti-inflammatory activity test showed that the percentage value of stability and hemolysis of extracts with doses of 50, 100, 200, 400, 800, 1600, and 3200 ppm were 55% and 45%, 63% and 37%, 70% and 30%, 74% and 26%, 80% and 20%, 87% and 13%, and 97% and 3%, respectively. It showed that extract of sponge Callyspongia sp. in all varied dose has activity in stabilizing the HRBC membrane thus can be potential as an anti-inflammatory. The results of acute toxicity assay showed that the value of LC50 was 1281.45 μg/ml and categorized as nontoxic to Artemia salina Leach. Conclusion: Various concentrations of Callyspongia sp. effective as an anti-inflammatory in stabilizing HRBC, and categorized as safe.

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Isolation and molecular characterization of bioactive secondary metabolites from Callyspongia spp. associated fungi

Cited by 16 publications

References 15 publications

Fungal diversity of mangrove-associated sponges from New Washington, Aklan, Philippines

Fungal diversity of mangrove-associated sponges from New Washington, Aklan, Philippines

Analytical characterization and structure elucidation of metabolites from Aspergillus ochraceus MP2 fungi

Anti-Inflammatory Activity of Marine Sponge Callyspongia Sp. And Its Acute Toxicity

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