Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus

Résumé - Mots clés : Envenimation, scorpion, épidémiologie, fiches d'hospitalisation, Beni MellalAbstract -In Morocco, the province of Beni Mellal is one of the regions most affected by the problem of scorpion sting and envenomation. Objective: The aim of this research is to reduce cases of morbidity and mortality subsequent to scorpion envenomation through the analysis and interpretation of data recorded in hospital admission forms. Patients and methods: Our study covered 56 retrospective cases of scorpion poisoning during the year 2007, which were reported by the hospital's intensive care service in Beni Mellal province. Results: Results indicate that scorpion envenomation occurs mainly during summer time, in particular during June and July. Moreover, stings happen at night between 6PM and 6AM (56.8%). Youngsters with age less than or equal to 15 years are those most exposed to envenomation, with a male age of 14.92 ± 12.94 years. Furthermore, 71.4% of the hurt patients arrive at the hospital with general symptoms and 28.6% exhibit signs of vital distress. The therapy is still variable, and the rate of lethality at hospital is 8.92%. Statistical analysis of various factors studied in relation to survival prediction (recovery and mortality) showed a highly significant difference for each admission class (χ 2 = 13.72 and p < 0.001). Age of less than 15 years and cardiovascular are factors of risk for envenomed patients. Conclusion: Scorpion envenomation remains a public health problem in Morocco.

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“…Il contient aussi une diversité de neurotoxines composées de deux populations principales : les toxines à longue chaîne et à courte chaîne [15].…”

Section: Discussionunclassified

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

et al. 2009

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“…They have sequences and activities similar to the so-called ancestral defensins found in phylogenetically distant invertebrates (mussels, arachnids and the dragonfly Aeschnea cyanea). In addition to toxins and defensins, scorpion venoms also contain other types of CSab peptides, such as LVP1, a dimer composed of two chains structurally related to Na-channel toxins and functionally acting as a nontoxic lipolysis-activating protein [27]. A reorganization of the fourth disulfide bridge is widely present in the CSab peptides from Arachnida (see below).…”

Section: Arachnidamentioning

confidence: 98%

“…The functions of these genes are unknown at present. Some plant CSab peptides deleted a cysteine in their N-or C-termini, which might lead to the formation of a dimer by establishing an intermolecular disulfide bridge, as observed in scorpion venom LVP1 peptides [27]. For the plant CSab motif, a consensus sequence can be determined as fol-…”

Section: Plantmentioning

confidence: 99%

Phylogenetic distribution, functional epitopes and evolution of the CSαβ superfamily

Zhu

Gao

Tytgat

2005

Cell. Mol. Life Sci.

127

129

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A superfamily of proteins often conserves a common structural scaffold but develops diverse biochemical and biological functions during evolution. The understanding of evolutionary mechanisms responsible for this diversity is of fundamental importance not only in structural genomics but also in nature-guided drug design. A superfamily of peptides with a conserved CSalphabeta structural motif provides a considerably intriguing example to approach such an issue. The peptides from this superfamily have wide origins, ranging from plants to animals, and exhibit diverse biological activities, varying from a sweet-tasting protein to antibacterial defensins and animal toxins targeting ion channels. This review describes the phylogenetic distribution and structural classifi cation of this unique scaffold and provides new insights into its functional diversity from the perspective of sequence, structure and evolution.

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“…Biologic activities of peptides from nontoxic venom fractions have been previously described in Buthus occitanus tunetanus scorpion venom; these include lipolytic properties (Soudani et al, 2005), activation of nicotinic receptors in skeletal muscle cells (Cheikh et al, 2007), and inhibition of cardiac L-type calcium currents (Cheikh et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Subtype-Selective Activation of K_v7 Channels by AaTXKβ_(2–64), a Novel Toxin Variant from theAndroctonus australisScorpion Venom

et al. 2013

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Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus

Cited by 44 publications

References 26 publications

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

Phylogenetic distribution, functional epitopes and evolution of the CSαβ superfamily

Subtype-Selective Activation of K_v7 Channels by AaTXKβ_(2–64), a Novel Toxin Variant from theAndroctonus australisScorpion Venom

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Isolation and molecular characterization of LVP1 lipolysis activating peptide from scorpion Buthus occitanus tunetanus

Cited by 44 publications

References 26 publications

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

Phylogenetic distribution, functional epitopes and evolution of the CSαβ superfamily

Subtype-Selective Activation of Kv7 Channels by AaTXKβ(2–64), a Novel Toxin Variant from theAndroctonus australisScorpion Venom

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Product

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Subtype-Selective Activation of K_v7 Channels by AaTXKβ_(2–64), a Novel Toxin Variant from theAndroctonus australisScorpion Venom