Isolation and initial characterization of primordial germ cell (PGC)-derived cells from goat, rabbit and rats

Lee, C.K.; Scales, N.; Newton, G. R.; Piedrahita, J.A.

doi:10.1016/s0093-691x(98)90741-5

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Ultrastructure Of Pgcs1

Pluripotent Embryonic Germ Cells1

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Cited by 8 publications

(2 citation statements)

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“…Germinal cytoplasm in all the lower vertebrates have a similar morphology. Germinal cytoplasm doesn't exist in mammalians (Francavilla et al 1990;Lee et al 1998;Lee et al 2000). PGCs are morphologically larger and usually located very close to the somatic cells (Fig.…”

Section: Ultrastructure Of Pgcsmentioning

confidence: 99%

Identification of Primordial Germ Cells: Cytological, Histological and Immunohistochemical Aspects

Yön

Akbulut

2015

Braz. arch. biol. technol.

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Section: Ultrastructure Of Pgcsmentioning

confidence: 99%

Identification of Primordial Germ Cells: Cytological, Histological and Immunohistochemical Aspects

Yön

Akbulut

2015

Braz. arch. biol. technol.

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“…Attempts to isolate caprine germ cells have also been reported (Lee et al, 1998). Caprine PGCs were isolated from day 32 fetuses and cultured on STO cells in the presence of LIF (Kuhholzer et al, 2000).…”

Section: Pluripotent Embryonic Germ Cellsmentioning

confidence: 99%

Pluripotent Stem Cells and Reprogrammed Cells in Farm Animals

Nowak‐Imialek¹,

Kues²,

Carnwath³

et al. 2011

Microsc Microanal

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Pluripotent cells are unique because of their ability to differentiate into the cell lineages forming the entire organism. True pluripotent stem cells with germ line contribution have been reported for mice and rats. Human pluripotent cells share numerous features of pluripotentiality, but confirmation of their in vivo capacity for germ line contribution is impossible due to ethical and legal restrictions. Progress toward derivation of embryonic stem cells from domestic species has been made, but the derived cells were not able to produce germ line chimeras and thus are termed embryonic stem-like cells. However, domestic animals, in particular the domestic pig (Sus scrofa), are excellent large animals models, in which the clinical potential of stem cell therapies can be studied. Reprogramming technologies for somatic cells, including somatic cell nuclear transfer, cell fusion, in vitro culture in the presence of cell extracts, in vitro conversion of adult unipotent spermatogonial stem cells into germ line derived pluripotent stem cells, and transduction with reprogramming factors have been developed with the goal of obtaining pluripotent, germ line competent stem cells from domestic animals. This review summarizes the present state of the art in the derivation and maintenance of pluripotent stem cells in domestic animals.

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Oocyte Development before and during Folliculogenesis

Pepling

2013

Oocyte Physiology and Development in Domestic Animals

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Isolation and initial characterization of primordial germ cell (PGC)-derived cells from goat, rabbit and rats

Cited by 8 publications

References 0 publications

Identification of Primordial Germ Cells: Cytological, Histological and Immunohistochemical Aspects

Identification of Primordial Germ Cells: Cytological, Histological and Immunohistochemical Aspects

Pluripotent Stem Cells and Reprogrammed Cells in Farm Animals

Oocyte Development before and during Folliculogenesis

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