Isolation and in vitro function of baboon pancreatic islets and their capacity to reverse experimental diabetes in nude mice

Immunoregulation of Dendritic Cells

“…TGF-β of T lymphocyte, monocyte/macrophage or granulocyte origin is typically detected at sites of inflammation. 39 Among the three isoforms of TGF-β, TGF-β1 exhibits the broadest spectrum of biological activities. Notably, TGF-β1 promotes early dendritic cell development in vitro and suppression of immature dendritic cell activation and maturation.…”

Regulatory T cells and tolerogenic dendritic cells: from basic biology to clinical applications

“…Intravenous administration of myeloid iDCs generated in vitro with GM-CSF can prolong the survival of pancreatic islet or heart allografts [106,107]. A theoretical drawback of this approach is the possibility that, following injection, iDCs differentiate in vivo into mDCs with the ability to stimulate anti-donor T-cell responses and accelerate allograft rejection.…”

Suppression of the Immune Response to FVIII in Hemophilia A Mice by Transgene Modified Tolerogenic Dendritic Cells

“…Allograft survival can be prolonged by infusion of tDCs derived from the marrows, spleens, and solid organs of donor mice. [13][14][15][16][17] Moreover, indirect alloantigen presentation by recipient tDCs has also been shown to promote tolerance to allografts as well as amelioration of graft versus host disease. [18][19][20][21] tDCs can be enriched and expanded in vitro under a variety of culture conditions.…”