Isolation and Identification of Two New Flavanones and a Chalcone from Citrus kinokuni.

Iwase, Yukiko; Takahashi, Maki; Takemura, Yuko; Ju‐ichi, Motoharu; Ito, Chihiro; Furukawa, Hiroshi; Yano, Masamichi

doi:10.1248/cpb.49.1356

Cited by 26 publications

(10 citation statements)

References 23 publications

(20 reference statements)

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“…However, a clear correlation between the number of methoxy groups in the PMFs and their biological activities was not found, although PMF 5 (six methoxy groups), PMF 6 (five methoxy groups), and PMF 8 (four methoxy groups and a hydroxy group) showed greater biological activity than the other PMFs. Previous studies on PMF separation have used a multi-step procedure, including solvent extractions and column chromatography (Iwase et al, 2001;Li et al, 2007;Raman et al, 2005). Mak et al (1996) reported the preparation of PMFs from a water extract of citrus peel, but they did not measure the PMF content or the composition of the extract.…”

Section: Resultsmentioning

confidence: 99%

Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

Jang

Kang

et al. 2010

Food Chemistry

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Section: Resultsmentioning

confidence: 99%

Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

Jang

Kang

et al. 2010

Food Chemistry

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“…tomatoes (Yamamoto et al, 2004), citruses (Iwase et al, 2001), apples (Gaucher et al, 2013)) or herbal drugs (e.g.…”

Section: Introductionmentioning

confidence: 99%

In vitro structure-toxicity relationship of chalcones in human hepatic stellate cells

et al. 2015

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CitationIn vitro structure-toxicity relationship of chalcones in human hepatic stellate cells 2015 Toxicology This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In vitro AbstractXanthohumol (XN), the major prenylated chalcone from hops (Humulus lupulus L.), has received much attention within the last years, due to its multiple pharmacological activities including anti-proliferative, anti-inflammatory, antioxidant, pro-apoptotic, anti-bacterial and anti-adhesive effects. However, there exists a huge number of metabolites and structurallyrelated chalcones, which can be expected, or are already known, to exhibit various effects on cells. We have therefore analyzed the effects of XN and 18 other chalcones in a panel, consisting of multiple cell-based assays. Readouts of these assays addressed distinct aspects of cell-toxicity, like proliferation, mitochondrial health, cell cycle and other cellular features. Besides known active structural elements of chalcones, like the Michael system, we have identified several moieties that seem to have an impact on specific effects and toxicity in human liver cells in vitro. Based on these observations, we present a structure-toxicity model, which will be crucial to understand the molecular mechanisms of wanted effects and unwanted side-effects of chalcones.

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“…Flavonoids 1-10 were previously isolated from sweet oranges (C. sinensis). [18][19][20][21][22][23][24][25] The total concentration of flavonoids in the sample analyzed was 160.0 mg mL -1 and it was injected 20 times , respectively. This study showed the high quality and potential of the Brazilian CFPW considering the investigated compounds, which could serve as an inexpensive and readily available source of polymethoxylated flavonoids.…”

Section: Resultsmentioning

confidence: 99%

An Environmentally Friendly Procedure to Obtain Flavonoids From Brazilian Citrus Waste

Bellete¹,

Ramin²,

Porto³

et al. 2018

J. Braz. Chem. Soc.

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Currently, most food waste is used as animal feed and this process does not take advantage of the available chemical composition. A Brazilian example is the citrus fruit processing wastes (CFPW), which have begun to draw attention due to their biological importance. In order to access the main compounds of this matrix, an efficient and environmentally friendly procedure was tested. From this extract, flavonoids as naringenin, hesperitin, chrysoeriol, sinensetin, 3,5,6,7,3',4'-hexamethoxyflavone, nobiletin, 5-methoxysalvigenin, 3,5,6,7,8,3',4'-heptamethoxyflavone, 3,5,6,7,4'-pentamethoxyflavone and isosakuranetin were identified by high performance liquid chromatography (HPLC-UV), liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography-nuclear magnetic resonance (LC-NMR). This study describes the potential use of citrus waste as a source of biologically active compounds. The extraction method proposed for this work was not expensive and the flavonoids were obtained in large amounts, thus, this extraction method is being developed using pilot plant scale-up techniques and will soon be available to the industry at a low cost.

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Isolation and Identification of Two New Flavanones and a Chalcone from Citrus kinokuni.

Cited by 26 publications

References 23 publications

Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort. ex Tanaka and its antiproliferative effects

In vitro structure-toxicity relationship of chalcones in human hepatic stellate cells

An Environmentally Friendly Procedure to Obtain Flavonoids From Brazilian Citrus Waste

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