Isolation and Identification of Three New Flavones from Achillea millefolium L.

Falk, Adelia; Smolenski, Stanislaus J.; Bauer, Ludwig; Bell, Charles L.

doi:10.1002/jps.2600641119

Cited by 51 publications

(29 citation statements)

References 7 publications

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“…Ajania jastigiata has been shown to contain 5,4'-dihydroxy-7,3'-dimethoxyflavone (velutin) (Chumbalov et aI., 1972b), 5,4'-dihydroxy-6,7,3'-trimethoxyflavone (fastigenin) (Chumbalov et aI., 1974b), and quer- Falk et al (1975) cetin, luteolin, apigenin, and an apigenin-6,8-di-C-glucoside (Chumbalov and Zhubaeva, 1976 Shishkin and Bobrov, 1961) was also shown to accumulate artemetin (Shawl, 1993). Two xanthine oxidase inhibitory flavonoids, 5,7-dihydroxy-3,6,4'-trimethoxyflavone and 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone, have been identified recently from extracts of A. fruticulosa by Li et ai.…”

Section: Flavonoid Datamentioning

confidence: 98%

Flavonoids of the Sunflower Family (Asteraceae)

Bohm

Stuessy

2001

119

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This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. This book is dedicated to:Arthur Cronquist Outstanding plant systematist and major contributor to understanding taxonomic relationships within Asteraceae and Ralph E. Alston (1925Alston ( -1967) Visionary natural products chemist and geneticist who pioneered the use of chemical data in studies of plant systematics and evolution PrefaceCertainly many of the readers of this book will remember the early developments of chemosystematics in the late 1950s. We ourselves remember the excitement of these new data bearing on plant interrelationships. The hopes were high, the techniques were rapidly evolving, the quantities of data were large, and young workers were eagerly enthusiastic. Some even went so far as to predict that chemical data would soon replace morphological information as the basis for plant classification. These overly zealous predictions did not materialize, of course, as the history of plant systematics has amply shown during the past two centuries. If there is any distinct characteristic of systematics it is synthesis, as Lincoln Constance (1964) called it, the "unending synthesis." New tools generate new data and provide insights on additional dimensions of plant relationships. This will never change-we will continue to discover new tools and new data in the years ahead, and they will continue to be incorporated into the predictive general reference system of classification.The earlier efforts in chemosystematics focused on secondary plant products: alkaloids, betacyanins, carbohydrates, cyanogenic glycosides, glucosinolates, lipids, terpenoids, and especialiy flavonoids. The latter were particularly well suited for chemosystematic investigation for several reasons: ease of isolation and characterization, small amounts of plant material needed for analysis, stability of compounds especially through routine preparation of herbarium specimens, and low cost to obtain useful information. As a result of these considerable advantages, literally thousands of studies on use of flavonoids in plant systematics have been published. Although now with the present zest for macromolecular data from DNA restriction sites and sequences, there are fewer workers and laboratories dedicated to flavonoid chemosystematic studies; twenty years ago they were the new currency of exciting data in plant systematics.Because of many workers historically interested in the sunflower family, Asteraceae (or Compositae), in part due to its large size (approximately 23,000 species;Bremer, 1994), and because hundreds of flavonoid compounds were discovered in this family, many chemosystematic investigations have been completed on various taxa. Many studies came from the laboratories of R. A. Alston, B. L. Turner, and T. J. Mabry in the Department of Botany ...

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Section: Flavonoid Datamentioning

confidence: 98%

Flavonoids of the Sunflower Family (Asteraceae)

Bohm

Stuessy

2001

119

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“…millefolium L. Three flavones: 5-Hydroxy-3,6,7,4′-tetramethoxyflavone, artemetin, and casticin (Falk et al, 1975) A. millefolium L. Two sesquiterpene lactone-esters, and one sesquiterpene lactone-diol (Farooq et al, 2012) A. millefolium L. Guaianolides: Leucodin, 8α-angeloxy-leucodin, achillin, 8α-angeloxy-achillin, and desacetylmatricarin (Glasl et al, 2003) A. millefolium L. Santolinoidol, a bisabolene sesquiterpene (Fahed et al, 2016) A. setacea Waldst. & Kit.…”

Section: Microorganisms and Insects Abbreviationsmentioning

confidence: 99%

“…Many Achillea species are rich sources of flavones (Falk et al, 1975;Aljančić et al, 1999;Moradkhani et al, 2014), other flavonoids (Bruno and Herz, 1988;Tzakou et al, 1995a; …”

Section: Introductionmentioning

confidence: 99%

Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

Mohammadhosseini

Sarker

Akbarzadeh

2017

Journal of Ethnopharmacology

156

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“…The inhibitory activity of extracts of laurel with several solvents (95% aqueous ethanol, 50% aqueous ethanol and water) was 55, 22 that the active components of L. nobilis were hydrophobic. Therefore, laurel was first extracted with methanol, and the methanol extract was partitioned with water and organic solvents (dichloromethane, ethyl acetate and 1-butanol, successively), and then the active compounds in the dichloromethane and ethyl acetate layers were further investigated.…”

Section: Resultsmentioning

confidence: 99%

“…Since it has been reported that A. millefolium L. [22] and C. unshiu [23] contain non-glycosidic flavonoids, flavonoids are deduced to be the active components of A. millefolium L. and C. unshiu.…”

Section: Resultsmentioning

confidence: 99%

Constituents of Laurus nobilis L. inhibit recombinant human lanosterol synthase

et al. 2005

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Extracts from 37 kinds of foods and foodstuffs were tested for inhibitory activity against recombinant human lanosterol synthase. Among them, extracts from five samples showed significant inhibition. Potent activity (55%) was found in 95% ethanol extract of Laurus nobilis L. Therefore, large-scale methanol extraction of the plant was carried out, and the constituents were separated by partition and fractionation by silica gel chromatography and HPLC. Four flavonoids, kaemperol 3-O-[2¢¢,4¢¢-O-di-E-p-coumaroyla-L-pyranorhamnoside] (1); 3,3¢,4¢,5,6,7,8-heptamethoxyflavone (2); 3¢, 4¢,5,6,7,8-hexamethoxyflavone (nobiletin) (3); and 4¢,5,6,7,8-pentamethoxyflavone (tangeretin) (4); and six sesquiterpens, eremanthine (5), dehydrocostus lactone (6), costunolide (7), zaluzanin C (8), zaluzanin D (9) and reynosin (10) were isolated. Eremanthine (5) showed the most potent activity, 70% inhibition, at the concentration of 500 lM.

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Isolation and Identification of Three New Flavones from Achillea millefolium L.

Cited by 51 publications

References 7 publications

Flavonoids of the Sunflower Family (Asteraceae)

Flavonoids of the Sunflower Family (Asteraceae)

Chemical composition of the essential oils and extracts of Achillea species and their biological activities: A review

Constituents of Laurus nobilis L. inhibit recombinant human lanosterol synthase

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