Isolation and Identification ofα-Glucosidase Inhibitors from Tochu-cha (Eucommia ulmoides)

Caffeoylsophorose, a New Natural α-Glucosidase Inhibitor, from Red Vinegar by Fermented Purple-Fleshed Sweet Potato

“…[8][9][10] Among our results, anthocyanins have been found to inhibit the digestion of carbohydrates via maltase inhibition. 6) In particular, a major diacylated anthocyanin of YGM-6 (peonidin (Pn) 3-O-(2-O-(6-O-E-feruloyl (Fer)--D-glucopyranosyl)-6-O-E-caffeoyl (Caf)--D-glucopyranoside)-5-O--D-glucopyranoside) in Ipomoea batatas cv Ayamurasaki 11,12) was identified as a potent maltase inhibitor (IC 50 of 200 M).…”

“…Many natural food resources [8][9][10] have been examined for their AGH inhibitory activity. Among them, a human study reported by Fujita et al 9) has pointed out that, even if an AGH inhibitor was from a natural food component, efficient postprandial BGL control could be achieved, in which 0.3 g of inhibitor ingestion after 200 g of cooked rice resulted in a 40% reduction in BGL rise in diabetic subjects.…”

Luteolin, a Flavone, Does Not Suppress Postprandial Glucose Absorption Through an Inhibition of α-Glucosidase Action

“…1,2) The retardation of membrane-bound AGH reaction 3) and W or inhibition of passive glucose transport 4) would successfully ‰atten the postprandial blood glucose excursions or reduce hyperglycemia. In our studies on AGH inhibition by food components, 5,6) acylated anthocyanins were found to cause the beneˆt of suppression of glucose production from dietary carbohydrates.…”

“…In addition, their alternative physiological function of suppression of glucose absorption at the small intestine has been also reported. 1,10) Among the ‰avo-noids, tea polyphenols such as catechins have been found to inhibit AGH activity 2) and glucose transport. 4) Theseˆndings led us to make a further investigation of ‰avonoids commonly present in plant and food products for any anti-hyperglycemic eŠect.…”

α-Glucosidase Inhibitory Activity of a 70% Methanol Extract from Ezoishige (Pelvetia babingtoniide Toni) and Its Effect on the Elevation of Blood Glucose Level in Rats

“…In previous in vitro studies, a-glucosidase inhibitors have been isolated from various food materials, e.g., ougon, 3) hijiki, 4) tochu-cha, 5) welsh onion, 6) and clove. 7) However, the in vitro inhibitory activity is not always related to the in vivo activity for physiological action.…”