Isolation and identification of furanocoumarins and a phenylpropanoid from the acetone extract and identification of volatile constituents from the essential oil of Peucedanum pastinacifolium

Sajjadi, Seyed Ebrahim; Shokoohinia, Yalda; Hemmati, Saeed

doi:10.1007/s10600-012-0343-9

Cited by 12 publications

(9 citation statements)

References 12 publications

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“…The Apioideae subfamily has been most intensely investigated and is characterized by the widespread occurrence of furo-and pyranocoumarins. [ 26 27 28 ]…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

et al. 2015

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Background:Ferulago macrocarpa is a plant used as flavoring agent and protectant in the food industry and as a folk medicinal plant in Iran with no available information on its chemical identity. Ferulago spp. showed to contain biologically terpenoids and coumarins.Objective:The objective was to isolate and characterize terpenoids and coumarins from the acetone extract of F. macrocarpa fruits and to evaluate their antiproliferative effects on several cell lines.Materials and Methods:A series of normal and reverse phase gravity and high-performance liquid chromatography analyses were used to purify constituents. Compounds 1–5 and 7 were evaluated for their cytotoxic effects on MCF-7, HT-29 and H-1299 cell lines.Results:Six compounds including bornyl acetate (1), 1,10-di-epi-cubenol (2), stigmasterol (3) and three coumarins grandivittin (4), prantschimgin (5) and 4”-hydroxygrandivittin (7) along with mixtures of feruloyl derivatives (6a-6c) have been purified. Their structures were established by spectroscopic methods including nuclear magnetic resonance and MS analyses. Compound 2 showed moderate cytotoxicity effect with IC50 values of 5.0 and 6.7 mM on MCF-7 and HT-29, respectively.Conclusion:1,10-di-epi-Cubenol could be considered as a potential proliferation inhibitor of MCF-7 and HT-29 cell lines.

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“…The Apioideae subfamily has been most intensely investigated and is characterized by the widespread occurrence of furo-and pyranocoumarins. [ 26 27 28 ]…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

et al. 2015

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“…Moreover, HAE of P. pastinacifolium indicated higher scavenging activity than Chaerophyllum macropodum Boiss (21). Phytochemical investigation showed presence of bergapten in acetonic extract of P. pastinacifolium (13) which is able to scavenge DPPH free radical due to its phenolic ring (22). Phenolic compounds act as free radical acceptors and chain breaker.…”

Section: Discussionmentioning

confidence: 99%

“…reported the chelating ability of Laser trilobum L from Umbelliferae family (24). Phytochemical analysis demonstrated the presence of methyl eugenol and eugenol in essential oil of P. pastinacifolium (13). Wannes and et al .…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant effects of hydroalcoholic and polyphenolic extracts of Peucedanum pastinacifolium Boiss. & Hausskn.

2016

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Antioxidant activity of Peucedanum pastinacifolium Boiss. & Hausskn aerial part hydroalcoholic extract (HAE) and polyphenolic extract (PPE) as well as their total phenolic and flavonoid contents were studied. Phenolic and flavonoid contents were respectively estimated as gallic acid and quercetin equivalents. The in vitro antioxidant activity of two extracts of P. pastinacifolium were evaluated by radical scavenging of 1,1-diphenyl-2-picryl hydrazyl radical (DPPH), chelating activity on ferrous ions, or ferric reducing antioxidant power (FRAP) assay. In addition, the in vivo antioxidant activity of hydroalcoholic extract was measured by FRAP assay. Total phenolic contents of PPE and HAE were 117.1 ± 6.2 and 44.3 ± 1.7 mg/g, respectively. Total flavonoid content of PPE (43.4 ± 2.1 mg/g) was found to be higher than that of HAE (8.0 ± 1.5 mg/g). In DPPH radical scavenging assay, HAE and PPE showed fifty percent inhibitory concentration (IC50) values of 469.4 ± 9.3 μg/mL and 128.2 ± 5.5 μg/mL, respectively. Iron chelating activity assays indicated IC50 values of 657.5 ± 13.2 μg/mL and 735.4 ± 16.1 μg/mL for HAE and PPE as opposed to ethylenediamine tetra-acetic acid (EDTA) being 16.5 ± 0.8 μg/mL. PPE exhibited greater FRAP value (154.0 ± 1.8 μM) as compared with that of HAE being 69.3 ± 1.4 μM. In animal study, HAE showed a significant (p < 0.05) increase in FRAP level when compared with that of control group. Our results showed that P. pastinacifolium possess antioxidant properties which most likely are exerted through free radical scavenging, chelating activity, and reducing power.

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“…Naturally occurring coumarins are structurally distinct dietary constituents found in Rutaceae, Apiaceae and Moraceae families (1)(2)(3)(4). More than 1300 coumarins have been identified as secondary metabolites from plants, bacteria, and fungi, showing numerous pharmacological properties such as anticancer, antiviral, and antioxidant effects (5-7).…”

Section: Introductionmentioning

confidence: 99%

Safety Assessment of Osthole Isolated from Prangos ferulacea: Acute and Subchronic Toxicities and Modulation of Cytochrome P450

Shokoohinia

Bazargan

Miraghaee

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Osthole (7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one), a natural coumarin derivative, has exhibited various pharmacological properties. In addition, the possibility of its development as a promising lead compound for drug discovery has been proposed. However, there is little toxicological information regarding safety of repeated exposure to this coumarin. Objective: The present study evaluated the potential toxicity of osthole after acute and subchronic administration in rodents. In addition, we investigated the effect of osthole on different hepatic CYP gene expressions in male rats receiving the highest dose of osthole. Methods: In the acute toxicity study, single doses of osthole (100, 500, and 1000 mg/kg) were administered intraperitoneally to mice and the mice were then monitored for 14 days. In the subchronic toxicity study, osthole was administered orally to rats at doses of 5, 25, and 50 mg/kg/day for 45 days. Results:The results of acute study indicated that LD50 of osthole is about 710 mg/kg. There was no significant difference in body weight, relative organ weight, and hematological parameters in the subchronic toxicity study. Biochemical analysis showed some significant changes including in creatinine, potassium, glucose, albumin, and urea levels. The results of histopathological studies showed that all the removed organs, specially kidney, were affected by subchronic exposure to osthole. The change in the kidney included peritubular capillary congestion, hemorrhage in renal parenchyma, mild tubular dilatation, and mild interstitial infiltration of inflammatory cells. Furthermore, osthole treatment caused an induction in CYP1A2, CYP2E1, and CYP2C11. Conclusions: Finally, concerning the common classification of relative toxicity of chemicals, acute toxicity results suggested that osthole is a moderately toxic substance when administered i.p. The obtained data from subchronic study supported the evidence of renal function impairment by osthole. The no-observed adverse-effect level (NOAEL) of the extract for both male and female rats is considered less than 5 mg/kg.

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Isolation and identification of furanocoumarins and a phenylpropanoid from the acetone extract and identification of volatile constituents from the essential oil of Peucedanum pastinacifolium

Cited by 12 publications

References 12 publications

Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits

Antioxidant effects of hydroalcoholic and polyphenolic extracts of Peucedanum pastinacifolium Boiss. & Hausskn.

Safety Assessment of Osthole Isolated from Prangos ferulacea: Acute and Subchronic Toxicities and Modulation of Cytochrome P450

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