Isolation and Identification of Antioxidants from Makgeolli

Wang, Seung-Jin; Lee, Hyoung Jae; Cho, Jeong-Yong; Park, Keun-Hyung; Moon, Jae‐Hak

doi:10.9721/kjfst.2012.44.1.014

Cited by 18 publications

(5 citation statements)

References 16 publications

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“…The principal sources in the human diet are olive oil and wine [7,8]. It is also one of the natural phenols in the traditional Korean rice wine makgeolli and is present in a greater proportion than other phenolic compounds [9]. Tyrosol has various biological activities.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Tyrosol Metabolites in Rats

Lee

Kim

et al. 2016

Molecules

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Abstract:Tyrosol is considered a potential antioxidant; however, little is known regarding the pharmacokinetics of its metabolites. To study the pharmacokinetics of tyrosol-derived metabolites after oral administration of a single dose of tyrosol, we attempted to identify tyrosol metabolites in rat plasma by using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Two tyrosol metabolites (M1 and M2) were detected in the plasma. M1 was identified as tyrosol-4-sulfate (T4S) with an [M´H]´ion at m/z 217. While M2 showed an [M´H]´ion at m/z 151.0, its metabolite was not identified. Pharmacokinetic analysis of T4S and M2 showed rapid uptake after oral administration of tyrosol within 1 h. The metabolites were rapidly distributed in most organs and tissues and eliminated within 4 h. The greatest T4S deposition by tissue weight was observed in the liver, followed by the kidney and spleen, while M2 was most concentrated in the kidney followed by the liver and spleen. These findings indicate that T4S and M2 were distributed mainly in tissues with an abundant blood supply and were rapidly excreted in urine.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Tyrosol Metabolites in Rats

Lee

Kim

et al. 2016

Molecules

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“…Representative flora that causes skin inflammation includes P. acnes. P. acnes mainly resides around and inside the hair follicles and secretes lipase, one of the enzymes that break down most of the human body's lipids, to break down neutral fat or triglycerides, the main components of sebum, into free fatty acids thereby causing inflammation and expanding the inflammation to cause acne [29]. In order to develop inhibitors of antibiotic-resistant bacteria, recently, studies to extract natural antibacterial substances from plant extracts have been actively in progress.…”

Section: Results Of Antibacterial and Anti-inflammatory Activity Testsmentioning

confidence: 99%

Antioxidant and Antibacterial Effects of Mixed Extracts of Phyllanthus emblica, Geranium (Pelargonium graveolens) and Commiphora myrrha: Possibility of Natural Materials for Acne Treatment

Choi¹,

Kim²

2023

Microbiol. Biotechnol. Lett.

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Various skin diseases are occurring due to external factors such as urbanization and increase in environmental pollution and wearing masks due to COVID-19. Accordingly, various functional cosmetics are being released, but as some side effects are reported, research on functional cosmetics materials using natural plants is necessary. Therefore, in this study, the antioxidant, antibacterial and anti-inflammatory effects of Phyllanthus emblica, Geranium (Pelargonium graveolens), and Commiphora myrrha mixed extracts (PGC) that pharmacological efficacy has been verified were analyzed and their potential as functional cosmetics raw materials was examined. Four extracts (PGC-1~4) were prepared according to the extraction method. ABTS and DPPH radical scavenging activity experiments were conducted for the antioxidant efficacy of the extracts. In addition, paper disc experiments and LPS inflammation-inducing cytokine experiments were conducted to examine the antibacterial and anti-inflammatory effects. In addition, a cell viability test was performed to confirm cytotoxicity. As results of the study, all extracts showed antioxidant, antibacterial, and anti-inflammatory effects without cytotoxicity, and in particular, PGC-4, a fermentation and ultrasonic extract, showed the best efficacy. This means that the extraction yield of useful components varies depending on the extraction method.

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“…Tyr (2-(4-hydroxyphenyl)ethanol) is present in a variety of natural sources [21][22][23][24][25]. The principal sources of Tyr are olive oil and wine [26,27].…”

Section: Sources Of Tyrmentioning

confidence: 99%

Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant

Плотников¹

2021

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The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of the results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as olive oil and wine. Tyr has a wide spectrum of biological activity: antioxidant, stress-protective, anti-inflammatory, anticancer, cardioprotective, neuroprotective and many others. This review analyzes data on the neuroprotective, antioxidant, anti-inflammatory, anti-apoptotic and other kinds of Tyr activity as well as data on the pharmacokinetics of the substance. The data presented in the review substantiate the acceptability of tyr as the basis for the development of a new neuroprotective drug with multitarget activity for the treatment of ischemic stroke. Tyr is a promising molecule for the development of an effective neuroprotective agent for use in ischemic stroke.

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Isolation and Identification of Antioxidants from Makgeolli

Cited by 18 publications

References 16 publications

Pharmacokinetics of Tyrosol Metabolites in Rats

Pharmacokinetics of Tyrosol Metabolites in Rats

Antioxidant and Antibacterial Effects of Mixed Extracts of Phyllanthus emblica, Geranium (Pelargonium graveolens) and Commiphora myrrha: Possibility of Natural Materials for Acne Treatment

Tyrosol as a Neuroprotector: Strong Effects of a “Weak” Antioxidant

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