Isolation and Identification of Acetyl-CoA Carboxylase Inhibitors from Green Tea (Camellia sinensis).

Watanabe, Jun; Kawabata, Jun; Niki, Ryoya

doi:10.1271/bbb.62.532

Cited by 67 publications

(80 citation statements)

References 14 publications

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“…Sayama et al, reported that the addition of green tea powder (GTP) to the diet suppressed fat accumulation and body weight increase without reduction of food intake in mice [17]. Moreover, it was reported that epigallocatechin gallate (EGCG), a kind of catechin, had an inhibitory effect on acetylCoA carboxylase which is essential for in vitro fatty acid biosynthesis [18]. Weight loss (one of the clinical features of diabetes) seen in alloxan-treated animals may be due to the degeneration of the adipocytes and muscle tissues to compensate for the energy lost from the body due to frequent urination and overconversion of glycogen to glucose [19].…”

Section: Results and Discussion Changes In Body Weightmentioning

confidence: 99%

Effect of Green Tea Aqueous Extract on Body Weight, Glucose Level, and Kidney Functions in Diabetic Male Albino Rats

Al-Hilfy

2012

JNUS

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The effect of daily oral doses of green tea water extract for 4 weeks on body weight, plasma glucose level, kidney functions in alloxan-induced diabetic rats was investigated. Forty adult male albino rats (150 -160 g) was divided into 4 experimental groups: The first group was considered as control group. The second group was treated with water extract of the green tea (200 mg/kg b.w).The third group was infected by induction of experimental diabetes by intraperitonial injection of (150 mg/kg b.w) alloxan, and the fourth group was infected by induction diabetes and treated with green tea extract. Different physiological parameters were performed including recording of the body weight and measuring blood sugar, creatinine and urea levels. Body weight loses, plasma glucose, creatinine, and urea levels were significantly (p< 0.05) reduced in diabetic rats treated with green tea when compared with the diabetic rats. From these results, it can be conclude that the consumption of green tea extract produced a significant reduction in glucose level in diabetic rats. In addition, it is capable of improving the impaired kidney functions in diabetic animals.

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Section: Results and Discussion Changes In Body Weightmentioning

confidence: 99%

Effect of Green Tea Aqueous Extract on Body Weight, Glucose Level, and Kidney Functions in Diabetic Male Albino Rats

Al-Hilfy

2012

JNUS

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“…ACC is the rate-limiting step in fatty acid synthesis for catalyzing the conversion of acetyl-CoA to malonyl-CoA (the precursor of fatty acids). When green tea ECG or EGCG was incubated with rat liver ACC, both catechins (with a Ki of 310 lM) inhibited the activity of ACC [63]. However, neither (+)-catechin, EC, nor EGC has that effect.…”

Section: Inhibition Of Lipogenic Enzymesmentioning

confidence: 96%

Tea, obesity, and diabetes

Kao¹,

Chang

Lee

et al. 2006

Molecular Nutrition Food Res

291

204

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Tea has been found to possess widespread biological functions based on a variety of laboratory data. The effects of tea on obesity and diabetes have received increasing attention. This paper reviews the evidence for the connections among tea catechins, and obesity and diabetes. Tea catechins, especially (-)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. While few epidemiological and clinical studies show the health benefits of EGCG on obesity and diabetes, the mechanisms of its actions are emerging based on the various laboratory data. These mechanisms may be related to certain pathways, such as through the modulations of energy balance, endocrine systems, food intake, lipid and carbohydrate metabolism, the redox status, and activities of different types of cells (i. e., fat, liver, muscle, and beta-pancreatic cells). Because the EGCG receptor, the so-called 67-kDa laminin receptor (LR), has been discovered with colocalization of other types of LR and cytoskeleton in both cancer cells and normal cells, this may explain that EGCG possesses numerous actions. The mechanistic results of this review may possibly be utilized in the treatment of obesity, diabetes, and other related diseases using tea- and EGCG-based folk medicines.

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“…8) Each sample was assayed for SOD activity by using a colorimetric SOD assay kit (Dojindo Molecular Tec.). The absorbance was measured at 450 nm with a plate reader to determine the percentage SOD activity as ½ðA blank 1 À A blank 3 Þ À ðA sample À A blank 2 Þ=ðA blank 1 À A blank 3 Þ Â 100%.…”

Section: Methodsmentioning

confidence: 99%