Isolation and Evaluation of Mucilage of <i>Adansonia digitata</i> Linn as a Suspending Agent

Deshmukh, S. S.; Katare, Y. S.; Shyale, Somashekar; Bhujbal, Santosh S.; Kadam, Shalaka; Landge, Dhananjay; Shah, Divyesh; Pawar, Jaydeep

doi:10.1155/2013/379750

Cited by 24 publications

(29 citation statements)

References 4 publications

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“…Paediatric and adult paracetamol (PCM) suspensions were prepared according to the composition given in table 1. The prepared suspensions were evaluated for pH, sedimentation volume (F), redispersibility and flowability for a period of 5 d at 25 °C [23,24].…”

Section: As Suspending Agentmentioning

confidence: 99%

Exploring Properties of Sweet Basil Seed Mucilage in Development of Pharmaceutical Suspensions and Surfactant-Free Stable Emulsions

Avlani¹,

Agarwal²,

Khattry³

et al. 2019

Int J App Pharm

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Objective: The objective of the investigation was to isolate mucilage from sweet basil seeds and explore its physicochemical properties for the development of pharmaceutical suspensions and surfactant-free stable emulsions.Methods: Possible applications of sweet basil seed mucilage in the pharmaceutical field for dosage form development are being explored. The physicochemical and functional properties of the mucilage from the seeds of the Ocimum basilicum L. (Sweet basil) have been investigated for stabilization of suspensions and emulsions. The following analyses were performed: FTIR spectroscopy, phytochemical tests, XRD, swelling and rheological studies.Results: The analyses showed that the mucilage is rich in glucose, mannose, and xylose. High swelling index values varying from 100±10 to 200±13%, high water-holding capacity of 97.5±2.4 g/g mucilage and reasonable oil holding capacity of the mucilage (13.2±1.3 g/g mucilage) makes it an ideal candidate for utilization as viscosifier and stabilizer of suspensions and surfactant-free emulsions. Adult and paediatric paracetamol suspension formulations with 1%w/v mucilage have exhibited flocculated nature and good stability owing to its high sedimentation volume(F= 0.85-0.98) and good redispersibility. Sunflower oil emulsions prepared with 0.25%w/v mucilage demonstrated emulsion stability index of 105.714 on 5th day and extremely low creaming rate of 0.0004 cm/h thus confirming maximum stability compared to emulsions developed with 0.3-0.5% w/v mucilage.Conclusion: The mucilage isolated from Ocimum basilicum L. seeds may be regarded as a functional biomaterial for pharmaceutical use to ensure quality and stability of liquid dosage forms.

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Section: As Suspending Agentmentioning

confidence: 99%

Exploring Properties of Sweet Basil Seed Mucilage in Development of Pharmaceutical Suspensions and Surfactant-Free Stable Emulsions

Avlani¹,

Agarwal²,

Khattry³

et al. 2019

Int J App Pharm

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“…The dried sample was weighed and ground into a fine mucilage powder using a mortar pestle and stored in a glass container inside the refrigerator for further analysis. [16]…”

Section: Isolation Of Mucilagementioning

confidence: 99%

Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application

Ang¹,

Raman²

2019

AJBLS

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Introduction: The edible leaves of Abelmoschus manihot Linn., Amaranthus spinosus Linn. and Talinum triangulare (Jacq.) Willd. are exhibiting mucilaginous features and are utilized in making soupy dishes. However, the utilization of the said plant species as sources of mucilages for pharmaceutical excipient application has not yet been reported in literatures. Objectives:The study aimed to extract and partially characterize mucilages from the leaves of A. manihot, A. spinosus and T. triangulare. for potential pharmaceutical excipient application. Materials and Methods: Mucilages were extracted from the leaves of A. manihot, A. spinosus and T. triangulare. Preliminary qualitative tests as well as determination of the physico-chemical properties, i.e. pH, solubility, swelling index, loss on drying, total sugar content and total uronic acid content, were conducted on the extracted mucilages. Identification of functional groups were also carried out through Fourier Transform Infrared (FTIR) spectroscopy. Results and Discussion: Results of the qualitative tests showed detection of carbohydrates, polysaccharides and mucilages among the mucilages extracted from A. manihot, A. spinosus and T. triangulare. The pH values of the extracted mucilage were nearly neutral indicating that they can be less irritating to the gastrointestinal tract when utilize for tablet formulations. Data obtained for the physico-chemical properties showed that mucilages of A. manihot gave statistically different values as compared to the mucilages derived from A. spinosus and T. triangulare. A. manihot mucilage exhibited significantly higher swelling index (357.78%) and total sugar content (273.65 mg glucose/g extract) and significantly lower loss on drying (10.72%) and total uronic acid content (105.20 mg glucuronic acid/g extract) than the other mucilages from A. spinosus and T. triangulare. Furthermore, FTIR spectral analysis showed typical peaks and characteristic bands of mucilage. Conclusion: A. manihot mucilage is promising for utilization as pharmaceutical excipient. However, further analysis is recommended.

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“…When the concentration of EPS in water was elevated from 0.25% to 1.0%, its viscosities were increased two times from 1.01 poise to 2.23 poise, and this also higher compared to that of pullulan (1.79 poise) (Sugimoto, 1978;Tsujisaka et al 1993) and Adansonia digitata mucilage (2.1 poise) in the same concentration of 1% (w/v) (Deshmukh et al 2013), indicating its high potential for use as a thickener in food industries. Scanning Electron Microscopic Analysis of C. lunata isolate RJ01 EPS SEM analysis on the structure of EPS from C. lunata RJ01 showed a typical surface of non-porous film ( Figure 9A) and appeared to have a compact structure ( Figure 9B).…”

Section: Viscosity Analysis Of Epsmentioning

confidence: 99%

Phenotypic and genotypic characteristics of exopolysaccharide-producing fungi as a source of food additives

et al. 2019

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Abstract. Akroman R, Nurhayati N, Suwasono S, Jayus J. 2019. Phenotypic and genotypic characteristics of exopolysaccharide-producing fungi as a source of food additives. Biodiversitas 20: 2468-2474. As the demand for materials suitable for edible film in food processing is increasing, the exploration of exopolysaccharide (EPS) producing fungi is important. Some fungi had been reported to produce extracellular polysaccharide having rheological properties potential as thickener and or plasticizer useful for edible film raw material. Therefore, this study was focused on isolation and identification of EPS-producing fungi from the plantation area surrounding the University of Jember, Indonesia. The fungal isolate obtained was morphologically identified based on mycelia and spore type, while its genotype was determined using ITS1 and ITS4 primers. The optimum initial culture pH for EPS production was measured using shake flask culture fermentation. The rheological properties of the EPS were determined using Brookfield viscometer, and surface structure of EPS was observed using a scanning electron microscope (SEM). The result showed that the mycelium of the isolate was reddish-brown and septated, its spores were formed as conidiospores. Internal Transcribed Spacer (ITS) sequence of the fungus showed that the isolate is a new species. Therefore, it was designated as C. lunata isolate RJ01. Optimum initial pH for EPS production was pH 6.0, achieved after 5 days fermentation yielded 2.6 g L-1 of EPS. The EPS from C. lunata isolate RJ01 have no cytotoxic activity on vero cell. The rheological behaviour of C. lunata EPS was viscous, and its surface structure of EPS was compact indicating its potency as thickening agent and plasticizer, a material required for edible film formation in food industries.

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Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent

Cited by 24 publications

References 4 publications

Exploring Properties of Sweet Basil Seed Mucilage in Development of Pharmaceutical Suspensions and Surfactant-Free Stable Emulsions

Exploring Properties of Sweet Basil Seed Mucilage in Development of Pharmaceutical Suspensions and Surfactant-Free Stable Emulsions

Characterization of Mucilages from Abelmoschus Manihot Linn., Amaranthus Spinosus Linn. and Talinum Triangulare (Jacq.) Willd. Leaves for Pharmaceutical Excipient Application

Phenotypic and genotypic characteristics of exopolysaccharide-producing fungi as a source of food additives

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