Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei

Sun, Zhang‐Hua; Chen, Yu; Guo, Yingjie; Qiu, Jie; Zhu, Cuige; Jin, Jing; Bu, Xianzhang; Yin, Sheng

doi:10.1016/j.bmcl.2015.01.056

Cited by 13 publications

(5 citation statements)

References 25 publications

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“…Due to its beautiful tree form, it is often planted in the courtyard as a valuable ornamental tree. Furthermore, Chinese yew is regarded as an important woody medicinal plant because it contains taxol as a natural anti-tumor drug with unique physiological functions in bark, branches and leaves (Sun et al, 2015). The mature Chinese yews form arils which cover the seeds.…”

Section: Introductionmentioning

confidence: 99%

A noteworthy case of rewilding Chinese yew from a garden population in eastern China

Zhang

et al. 2021

PeerJ

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Chinese yew (Taxus wallichiana var. mairei) is ranked as a rare and endangered plant of first-grade protection of China. It has been widely cultivated in 17 provinces of China over the past few decades. However, little is known about the dispersion, rewilding, and ecological influence of Chinese yew’s offspring during cultivation. Here, we report a noteworthy case of this species, via ex situ conservation, which has successfully spread into different secondary forests, thus forming a stable regenerating population in eastern China. The establishment of this yew population, which has > 900 individuals and 7 ha area, can be ascribed to two key ecological factors: (1) secondary forest near the parent yews that provided suitable microhabitats in which progeny yews could germinate and grow, and (2) seed-foraging and transportation by native birds. Thus, this case may offer a pathway for conserving endangered Chinese Taxus species, which can attract frugivorous birds to disperse their seeds. In addition, it is necessary to monitor the growth performance of progeny population in the field.

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Section: Introductionmentioning

confidence: 99%

A noteworthy case of rewilding Chinese yew from a garden population in eastern China

Zhang

et al. 2021

PeerJ

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“…In particular, we hypothesized that arylation at C6 could provide a rapid route to the cores of taxoids such as taxinine M ( 14 ). , Taxinine M and related taxoids possess a bridging ether ring that distinguishes them from most taxoid natural products. No syntheses of these natural products or their core structures have been reported to date.…”

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confidence: 99%

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C–C Bond Cleavage/Arylation Reaction

et al. 2015

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“…Cephalomannine is primarily derived from the twigs and leaves of Taxus × media , where it is present in high concentrations and exhibits notable activity. Cephalomannine, found in high concentrations in the twigs and leaves of Taxus × media , shows strong anticancer potential, particularly against breast cancer MCF-7 cells, with a dose-dependent IC50 value of 0.86 µg/m [ 69 ]. It also effectively inhibits P388 lymphocytic leukemia, highlighting its broad-spectrum anticancer activity [ 70 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

Research on the Medicinal Chemistry and Pharmacology of Taxus × media

Gao,

Zhang,

Xie

2024

IJMS

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Taxus × media, belonging to the genus Taxus of the Taxaceae family, is a unique hybrid plant derived from a natural crossbreeding between Taxus cuspidata and Taxus baccata. This distinctive hybrid variety inherits the superior traits of its parental species, exhibiting significant biological and medicinal values. This paper comprehensively analyzes Taxus × media from multiple dimensions, including its cultivation overview, chemical composition, and multifaceted applications in the medical field. In terms of chemical constituents, this study delves into the bioactive components abundant in Taxus × media and their pharmacological activities, highlighting the importance and value of these components, including paclitaxel, as the lead compounds in traditional medicine and modern drug development. Regarding its medicinal value, the article primarily discusses the potential applications of Taxus × media in combating tumors, antibacterial, anti-inflammatory, and antioxidant activities, and treating diabetes. By synthesizing clinical research and experimental data, the paper elucidates the potential and mechanisms of its primary active components in preventing and treating these diseases. In conclusion, Taxus × media demonstrates its unique value in biological research and tremendous potential in drug development.

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Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei

Cited by 13 publications

References 25 publications

A noteworthy case of rewilding Chinese yew from a garden population in eastern China

A noteworthy case of rewilding Chinese yew from a garden population in eastern China

Construction of Enantiopure Taxoid and Natural Product-like Scaffolds Using a C–C Bond Cleavage/Arylation Reaction

Research on the Medicinal Chemistry and Pharmacology of Taxus × media

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