Isolation and Cytotoxic Investigation of Flacourtin from Oncoba spinosa

Balogun, Olaoye Solomon; Ajayi, O. O.; Lawal, Olayinka Simbiat

doi:10.3390/medicines3040031

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Ethnopharmacological data has revealed that OS has been extensively used for the treatment of diabetes and cancer in Nigeria region [5]; leaves and roots are used in African countries for the treatment of urethral discharges, infertility, epilepsy, dysentery and bladder conditions [6][7][8]; fruits are used for the treatment of syphilis, wounds, parasitic worms, and sexual impotence [9]. α-glucosidase inhibitory, radical scavenging and cytotoxicity activities of OS leaves have been reported.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Oncoba spinosa on Key Enzymes Related to Diabetes Mellitus (A-Amylase and A-Glucosidase) and Obesity (Pancreatic Lipase) in Vitro

M¹,

Suba²,

B³

et al. 2017

J Diabetes Metab

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Aim and Objective: Oncoba spinosa Forssk. (Flacourtiaceae) (OS) is traditionally used for the management of diabetes mellitus. In previous studies, we studied the effect of OS on α-amylase and α-glucosidase inhibition, however the effect of OS on pancreatic lipase inhibition and kinetics of α-amylase, α-glucosidase and pancreatic lipase inhibition were not studied. This study determined the in vitro inhibitory effects of OS against pancreatic lipase and characterized the kinetics of α-amylase, α-glucosidase and pancreatic lipase inhibition. Materials and Methods:Dried powdered roots were successively extracted with various solvents such as petroleum ether, chloroform, ethyl acetate, and 70% ethanol. The successive extracts obtained (62.5-1000 μg/ml) were subjected to in vitro pancreatic lipase inhibitory assay and the most active extract was selected for kinetic studies.Results: Of all the successive extracts studied, the ethanolic extract showed highest pancreatic lipase inhibitory activity. The ethanolic extract showed mixed type of inhibition against α-amylase and pancreatic lipase whereas noncompetitive inhibition against α-glucosidase. Conclusion:The data of this study suggests that OS inhibits amylase, glucosidase and lipase activities, which leads to a reduction in the intestinal absorption of carbohydrates and lipids.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Oncoba spinosa on Key Enzymes Related to Diabetes Mellitus (A-Amylase and A-Glucosidase) and Obesity (Pancreatic Lipase) in Vitro

M¹,

Suba²,

B³

et al. 2017

J Diabetes Metab

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“…Balogun et al examine an endangered medicinal plant, Oncoba spinosa . This small tree grows in many areas of Africa [ 16 ]. The fruit is used in Traditional Healing in Nigeria.…”

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confidence: 99%

Does the World Need Plant Medicines?

Adams

2018

Medicines

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Chemical Constituents and Pharmacological Activities of Family Flacourtiaceae: A Class of Important Phytomedicine

et al. 2020

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Flacourtiaceae plants are widely used as folk medicines in traditional medicine systems for its chemical diversity and pharmacological activities. In many different areas, Flacourtiaceae plants are used as traditional medicines for the treatment of ulcers, malaria, rheumatism. The Flacourtiaceae plants contain a very plentiful chemical composition, and phytochemical studies show that the Flacourtiaceae plants contained terpenoids, aromatic glycosides, flavnoids, phenylpropanoids, alkaloids, fatty hydrocarbon, and other compounds. In pharmacological studies, various extract and isolated individual compounds exhibited antitumor, anti-oxidation, and anti-inflammatory activities. In this review, the literature data on the chemical constituents and pharmacological investigations of the Flacourtiaceae plants are summarized, to provide information about a more comprehensive chemical composition and detailed pharmacological activities of Flacourtiaceae plants, with a view of further development of clinical medication. However, research on quantitative analysis, toxicity, and drug safety in vitro and in vivo is still insufficient, and further research is required.

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Isolation and Cytotoxic Investigation of Flacourtin from Oncoba spinosa

Cited by 4 publications

References 6 publications

Inhibitory Effects of Oncoba spinosa on Key Enzymes Related to Diabetes Mellitus (A-Amylase and A-Glucosidase) and Obesity (Pancreatic Lipase) in Vitro

Inhibitory Effects of Oncoba spinosa on Key Enzymes Related to Diabetes Mellitus (A-Amylase and A-Glucosidase) and Obesity (Pancreatic Lipase) in Vitro

Does the World Need Plant Medicines?

Chemical Constituents and Pharmacological Activities of Family Flacourtiaceae: A Class of Important Phytomedicine

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