Isolation and characterization of the alkaloid Nitidine responsible for the traditional use of Phyllanthus muellerianus (Kuntze) Excell stem bark against bacterial infections

Cesari, I.; Grisoli, Pietro; Paolillo, Mayra; Milanese, Chiara; Massolini, Gabriella; Brusotti, Gloria

doi:10.1016/j.jpba.2014.11.051

Cited by 24 publications

(17 citation statements)

References 17 publications

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“…7). As already observed in our previous works (Cesari et al, 2015(Cesari et al, , 2013, these findings suggest that the presence of most of the same secondary metabolites in WE and DME, but with differences in the biological activity observed, might be ascribed to the too low percentage of the active compound/s within the crude WE and/or to the presence of interfering compounds (Butler, 2004).…”

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confidence: 85%

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In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts

Brusotti

Andreola

Sferrazza

et al. 2015

Journal of Ethnopharmacology

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supporting

confidence: 85%

“…Thus, following our research field on the validation of traditional uses of Baka pygmies medicinal plants (Ngueyem et al, 2008;Brusotti et al, 2011, Cesari et al, 2015, 2013, the aim of this work is to validate the traditional use of Drypetes klainei in the wound healing process and in the treatment of burns.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts

Brusotti

Andreola

Sferrazza

et al. 2015

Journal of Ethnopharmacology

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“…2011; Cesari et al. 2015 ). Despite the array of pharmacological activities and antioxidant phytochemicals, no study has evaluated the plant for its hepatoprotective activity.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers

Ajiboye

Ahmad

Daisi

et al. 2017

Pharmaceutical Biology

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Context: Leaves of Phyllanthus muellarianus (Kuntze) Exell. (Euphorbiacea) are widely used in the management of liver disorders in Nigeria. However, no there is no scientific validation to support this use.Objective: Hepatoprotective effect of Phyllanthus muellarianus aqueous leaf extract was investigated in acetaminophen-induced liver injury mice.Materials and methods: Hepatoprotective effect of Phyllanthus muellarianus aqueous leaf extract was evaluated in acetaminophen-induced hepatic damage in Swiss albino mice using biomarkers of hepatocellular indices, oxidative stress, proinflammatory factors and lipid peroxidation. Mice received distilled water, 100, 200, or 400 mg/kg b.w of Phyllanthus muellarianus aqueous leaf extract, respectively, for seven days. Treatment groups were challenged with 300 mg/kg b.w of acetaminophen on the sixth day.Results: Oral administration of Phyllanthus muellarianus aqueous leaf extract significantly (p < 0.05) attenuates acetaminophen-mediated alterations in serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, albumin and total bilirubin by 76.56, 85.41, 89.39, 82.77 and 78.38%. Similarly, acetaminophen-mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase were significantly attenuated in the liver of mice by 85.10, 80.81, 80.45, 76.23 and 95.22%, respectively. Increased levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl, fragmented DNA, tumor necrosis factor-α, interleukin-6 and -8 were significantly lowered by Phyllanthus muellarianus aqueous leaf extract.Conclusion: Overall, results of this study show that Phyllanthus muellarianus halted acetaminophen-mediated hepatotoxicity due to its capability to enhance antioxidant enzymes.

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“…In addition to that, most of them are known to have economic and medicinal uses. Some of them had already been used in ethno-medicine and extraction of antioxidant and other industrial chemicals (Ali et al 2006; Cesari et al 2015; Gebhardt et al 2003; Okafor et al 2008; Patel et al 2011; Thyagarajan et al 1988). So, it is very important to conserve those species in terms of ecology and economy.…”

Section: Introductionmentioning

confidence: 99%

Morpho-anatomical observations on Phyllanthus of Southwestern Bangladesh with two new records for Bangladesh

Tuhin

Limon

2019

Preprint

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An extensive floristic survey was done to annotate Phyllanthus of southwestern 7Bangladesh from 2015 to 2018. In total, 2189 individuals of Phyllanthus were counted and 8 identified as eight different species (five herbs, two trees and a shrub). All species were examined 9 following both morphological and anatomical methods, based on taxonomic notes. The listed 10 species were Phyllanthus acidus, Phyllanthus amarus, Phyllanthus debilis, Phyllanthus emblica, 11 Phyllanthus niruri, Phyllanthus urinaria, Phyllanthus reticulatus and Phyllanthus virgatus. 12 Among them, Phyllanthus amarus and Phyllanthus debilis were listed for the first time from 13 Bangladesh during this study period. 14 15 Phyllanthus debilis 16 58 Standard herbarium technique (Hyland 1972; Rahman et al. 2013) was used to collect the 59 herbarium specimen for analysis. Live specimens were photographed by Celestron handheld 60 digital microscope and Nikon-3200D camera with Nikkor 18-55mm AF-S DX, Nikkor 55-300mm 61 AF-S DX and Micro-Nikkor 105 mm FX AF lenses. We recorded GPS quadrate for all surveyed 62 sites with a GPS device (Garmin GPSMAP 76CSx). Image J (1.52a) was used to record 63 morphological measurements and image analysis. Herbarium sheets were prepared and deposited 64to FWT herbarium to conserve for future use. We did not collect any endangered angiosperm or 65 sample from any protected areas, hence no permission was required for the collections. Collected 66 specimens were analyzed and identified based on key provided by Hooker (1890), Prain (1904), Result 71 2189 individuals of Phyllanthus were examined and classified into eight different species from 72 southwestern part of Bangladesh. Among these, five were herbs, two trees and a shrubs. Expect 73 Phyllanthus debilis all the species were well distributed throughout the study area. Meanwhile, 74 Phyllanthus niruri, Phyllanthus urinaria, Phyllanthus amarus and Phyllanthus reticulatus were 75 very abundant in the study sites. But Phyllanthus virgatus were found in Jessore-Chuadangha belt 76 and absent in Khulna, Satkhira and Bhagerhat (table 2). Apart from these, Phyllanthus acidus and 77 Phyllanthus emblica could be listed as a plantation species as they were absent at natural habitats. 78 In addition to it, Phyllanthus amarus and Phyllanthus debilis were listed for the first time from 79 Bangladesh at current study. A Monoecious, glabrous, deciduous, small sized tree, up to 15m high; branches stout, leafless, 94 with slender deciduous leafy branchlets at the end; bark brownish. Leaves distichous, alternate, 95 stipulate, stipules lanceolate, 0.8-1 mm; petiolate, 1.5-3mm long, distichous; leaf blade ovate to 96 ovate-lanceolate, 3-8mm long and 1-3.5mm wide, leathery, acute to acuminate at apex, rounded 97 or broadly cuneate at base, lateral veins 7-9 pairs, sometimes indistinct. Flower bisexual, dark 98 reddish, at dense clusters forming slender, glabrous, in interrupted racemes, arising along the stem 99 and branches. Male flowers are minute, red; staminate, stamen 4, free, 2 shorter...

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Isolation and characterization of the alkaloid Nitidine responsible for the traditional use of Phyllanthus muellerianus (Kuntze) Excell stem bark against bacterial infections

Cited by 24 publications

References 17 publications

In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts

In vitro evaluation of the wound healing activity of Drypetes klainei stem bark extracts

Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers

Morpho-anatomical observations on Phyllanthus of Southwestern Bangladesh with two new records for Bangladesh

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