Abstract:Background Utilization of autologous stem cells has been proposed for the treatment of anal incontinence despite a lack of understanding of their mechanism of action and of the physiological healing process of anal sphincters after injury. Aims We aim to develop a technique allowing isolation and further study of local mesenchymal stem cells, directly from anal canal transition zone in pig. Methods Anal canal was resected "en bloc" from two young pigs and further microdissected. The anal canal transition zone … Show more
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