Isolation and characterization of potential food preservative peptide from Momordica charantia L.

Jabeen, Uzma; Khanum, Azra

doi:10.1016/j.arabjc.2014.06.009

Cited by 31 publications

(24 citation statements)

References 31 publications

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“…The need for the specific conformation of the peptide to function properly was supported by these results. Any changes to the mentioned conformation could result in the loss of its functions, including antimicrobial activity (Jabeen & Khanum, ). As evidenced from the results, the specific conformation of MCH‐AMP1 required for its antimicrobial activity might have changed at high and low temperatures.…”

Section: Discussionmentioning

confidence: 99%

Isolation, functional characterization, and biological properties of MCh‐AMP1, a novel antifungal peptide from Matricaria chamomilla L.

et al. 2019

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The antimicrobial activities of natural products have attracted much attention due to the increasing incidence of pathogens that have become resistant to drugs. Thus, it has been attempted to promisingly manage infectious diseases via a new group of therapeutic agents called antimicrobial peptides. In this study, a novel antifungal peptide, MCh‐AMP1, was purified by reverse phase HPLC and sequenced by de novo sequencing and Edman degradation. The antifungal activity, safety, thermal, and pH stability of MCh‐AMP1 were determined. This peptide demonstrated an antifungal activity against the tested Candida and Aspergillus species with MIC values in the range of 3.33–6.66 μM and 6.66–13.32 μM, respectively. Further, physicochemical properties and molecular modeling of MCh‐AMP1 were evaluated. MCh‐AMP1 demonstrated 3.65% hemolytic activity at the concentration of 13.32 μM on human red blood cells and 10% toxicity after 48 hr at the same concentration on HEK293 cell lines. The antifungal activity of MCh‐AMP1 against Candida albicans was stable at a temperature range of 30–50°C and at the pH level of 7–11. The present study indicates that MCh‐AMP1 may be considered as a new antifungal agent with therapeutic potential against major human pathogenic fungi.

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Section: Discussionmentioning

confidence: 99%

Isolation, functional characterization, and biological properties of MCh‐AMP1, a novel antifungal peptide from Matricaria chamomilla L.

et al. 2019

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“…Proteins and peptides are also the main functional components in the fruit and seeds of M. charantia . Many types of proteins and peptides have been isolated from different parts of M. charantia , such as ribosome inactivating proteins (RIPs), Momordica charantia lectin (MCL), Momordica anti-HIV protein of 30 kD (MAP30), α-momorcharin (α-MMC), β-momorcharin (β-MMC), γ-momorcharin, δ-momorcharin and ε-momorcharin, which possess RNA N -glycosidase activity, PAG activity, DNase-like activity, phospholipase activity, superoxide dismutase activity, anti-tumour, anticancer, immunosuppressive and anti-microbial activity [ 37 , 38 , 39 , 40 , 41 , 42 , 43 ].…”

Section: Chemical Compositionmentioning

confidence: 99%

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Jia

Shen

Zhang

et al. 2017

IJMS

282

173

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Momordica charantia L. (M. charantia), a member of the Cucurbitaceae family, is widely distributed in tropical and subtropical regions of the world. It has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used as a vegetable for thousands of years. Phytochemicals including proteins, polysaccharides, flavonoids, triterpenes, saponins, ascorbic acid and steroids have been found in this plant. Various biological activities of M. charantia have been reported, such as antihyperglycemic, antibacterial, antiviral, antitumor, immunomodulation, antioxidant, antidiabetic, anthelmintic, antimutagenic, antiulcer, antilipolytic, antifertility, hepatoprotective, anticancer and anti-inflammatory activities. However, both in vitro and in vivo studies have also demonstrated that M. charantia may also exert toxic or adverse effects under different conditions. This review addresses the chemical constituents of M. charantia and discusses their pharmacological activities as well as their adverse effects, aimed at providing a comprehensive overview of the phytochemistry and biological activities of M. charantia.

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“…Furthermore, fish and shellfish hydrolysates can have varied biological activities (antimicrobial [5], antioxidant [6] or antihypertensive [7]), so that they are attractive to the nutraceutical industry. Antimicrobial peptides are particularly attractive to aquaculture to improve disease resistance in farmed fish [8] or keep food safe and unspoiled from microorganism [9].…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of peptide fractions of a Tilapia (Oreochromis niloticus) by-product hydrolysate and in vitro evaluation of antibacterial activity

Robert

Zatylny-Gaudin

Fournier³

et al. 2015

Process Biochemistry

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Isolation and characterization of potential food preservative peptide from Momordica charantia L.

Cited by 31 publications

References 31 publications

Isolation, functional characterization, and biological properties of MCh‐AMP1, a novel antifungal peptide from Matricaria chamomilla L.

Isolation, functional characterization, and biological properties of MCh‐AMP1, a novel antifungal peptide from Matricaria chamomilla L.

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Molecular characterization of peptide fractions of a Tilapia (Oreochromis niloticus) by-product hydrolysate and in vitro evaluation of antibacterial activity

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