Isolation and Characterization of Paulownioside, A New Highly Oxygenated Iridoid Glucoside From Paulownia tomentosa

Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa

“…Its stem bark has been used in Chinese herbal medicine as a component of remedies for infectious diseases such as gonorrhea and erysipelas (Kang et al, 1999). Earlier studies of P. tomentosa led to the isolation of iridoids (Plouvier, 1971;Adriani et al, 1981;Damtoft and Jensen, 1993) and lignans (Ina et al, 1987;Takahashi and Nakagawa, 1966). Recently, diplacone, a geranylated favanone, has been reported from the flower (Du et al, 2004).…”

Ontogeny of the flowers in Paulownia tomentosa – A contribution to the recognition of the resurrected monogeneric family Paulowniaceae

“…Carbocyclic iridoids are characteristic of the Lamiales. Aucubin and catalpol are (carbocyclic) iridoids that are widespread in the Lamiales Stermitz, 1990, 1991;El-Naggar and Beal, 1980;Jensen et al, 1975) and are also reported from Paulownia (Adriani et al, 1981;Hegnauer and Kooiman, 1978). In addition, paulownioside (Adriani et al, 1981) and tomentosides (Damtoft and Jensen, 1993) have been found that have as yet not been reported from any other genus.…”

Geranylated Flavanones from <i>Paulownia coreana</i> and Their Inhibitory Effects on Nitric Oxide Production

“…It has been used traditionally to treat cough, phlegm, bronchitis, asthma, hemorrhoid, gonorrhea, and erysipelas. 1) Previous phytochemical studies of the genus Paulownia have reported the isolation of iridoids, 2,3) lignans, 4) furanoquinones, 5) phenolic glycosides, 6) and flavonoids. 7,8) Recently, geranylated flavonoids isolated from the genus Paulownia have been reported to possess a series of bioactivities including antiviral, 9) antioxidant, 10) antimicrobial, 11) cytotoxic, 12) and anti-cholinesterase activities.…”

“…In our continuing search for the plant-derived inhibitors of nitric oxide (NO) production, the methanolic extract of P. coreana was found to inhibit the lipopolysaccharide (LPS)-induced NO production in RAW264.7 cells. Subsequent bioassay-guided fractionation of the CH 2 Cl 2 -soluble fraction led to the isolation of a new geranylated flavanone, 3′-O-methyl-5′-hydroxydiplacol (1), together with 10 known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The structures of known isolates were elucidated on the basis of their spectroscopic analysis ( 1 H-, 13 C-NMR, and electrospray ionization (ESI)-MS) by comparison with those of published data.…”