Isolation and characterization of Marine fungal metabolites against clinical pathogens

Thirunavukkarasu, Rajasekar; Balaji, Sudharsan S.; Shanmugam, Kumaran; Deivasigamani, B.; Pugzhavendhan, S.R.

doi:10.1016/s2222-1808(12)60187-x

Cited by 17 publications

(12 citation statements)

References 11 publications

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“…The compounds are Dibutyl phthalate (6.95%), Heneicosane and 1-Heptacosanol (19.12%). Thus, high burden of multidrug resistant pathogens in the current world there is increasing interest for searching of effective antibiotics from soil microflora from diversified ecological niches (Rajasekar et al, 2012). All the seventeen compounds possess antibacterial, antifungal and antioxidant activity.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic potentials and isolation of metabolomes from microorganisms of mesophilic soil of Rajasthan, India

Sharma¹,

Menghani²

2017

Afr. J. Microbiol. Res.

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The present of research work was focused on mesophilic soil samples from four different sites of Jaipur (The Pink City) in Rajasthan. Rajasthan is a semi arid region and famous for its sandy soil, heat and temperature which reach up to 50°C in summers. Twenty nine colonies were isolated from the soil samples on nutrient agar media and three distinct isolates were selected and characterized after analyzing coloration of colony formation and zone of inhibition around and appearance of the colony. On the basis of biochemical tests, the isolates are suspected to belong to the genera, Bacillus, Actinomycetes and Staphylococcus. Antibiotic activity of the isolates was studied against some common nosocomial infection causing pathogens and promising results were observed. Out of 29 colonies, only 3 colonies viz. S-IA, S-IIA and S-IIIC showed appreciable biological activity against the above mentioned 2 test pathogens E. coli and Pseudomonas aeruginosa. Further, inhibition zones were calculated in S-IA (IZ = 12 mm; AI = 1.5); S-II A (IZ = 42 mm; AI = 4.2) and S-III C (IZ = 12 mm; AI = 1.1).

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Section: Discussionmentioning

confidence: 99%

Antibiotic potentials and isolation of metabolomes from microorganisms of mesophilic soil of Rajasthan, India

Sharma¹,

Menghani²

2017

Afr. J. Microbiol. Res.

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“…After the discovery of cephalosporin C, siccayne was isolated from Halocyphina vilosa and was identified as the second antibiotic from marine-derived fungi ( Kupka et al, 1981 ). Marine-derived fungi have been widely studied for novel anti-cancer, anti-bacterial, anti-plasmodial, anti-inflammatory, and anti-viral agents ( Rajasekar et al, 2012 ). However, very few anti-biofilm/anti-biofouling bioactive metabolites have been derived from marine fungi.…”

Section: Survey Methodologymentioning

confidence: 99%

Significance and potential of marine microbial natural bioactive compounds against biofilms/biofouling: necessity for green chemistry

Adnan

Al-Shammari

Patel

et al. 2018

PeerJ

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Natural products from the unique environments of sea water and oceans represent a largely unfamiliar source for isolation of new microbes, which are potent producers of secondary bioactive metabolites. These unique life-forms from the marine ecosphere have served as an important source of drugs since ancient times and still offer a valuable resource for novel findings by providing remedial treatments. Therefore, it can be expected that many naturally bioactive marine microbial compounds with novel structures and bioactivities against those from terrestrial environments may be found among marine metabolites. Biofilms in aquatic environment possess serious problems to naval forces and oceanic industries around the globe. Current anti-biofilm or anti-biofouling technology is based on the use of toxic substances that can be harmful to their surrounding natural locales. Comprehensive research has been done to examine the bioactive potential of marine microbes. Results are remarkably varied and dynamic, but there is an urgent need for bioactive compounds with environmentally friendly or “green” chemical activities. Marine microbes have the potential as upcoming and promising source of non-toxic compounds with sustainable anti-biofouling/anti-biofilm properties as they can produce substances that can inhibit not only the chemical components required for biofilm production but also the attachment, microorganism growth, and/or cell–cell communication.

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“…Most of the published work on secondary metabolites of marine fungi has focused on a few genera, mainly Penicillium, Aspergillus, Fusarium, and Cladosporium (Imhoff, 2016;Marchese et al, 2020). Marine fungi are found to be a promising source of pharmacologically active metabolites (Imhoff, 2016) with novel anticancer, antibacterial, antiviral, anti-plasmodial, antiinflammatory, but rarely antifouling, activities (Rajasekar et al, 2012;Bovio et al, 2019a). They are also useful in the production of biosurfactants (Cicatiello et al, 2016;Pitocchi et al, 2020), enzymes (Nicoletti and Andolfi, 2018), and bioremediation (Bovio et al, 2017).…”

Section: Fungimentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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Isolation and characterization of Marine fungal metabolites against clinical pathogens

Cited by 17 publications

References 11 publications

Antibiotic potentials and isolation of metabolomes from microorganisms of mesophilic soil of Rajasthan, India

Antibiotic potentials and isolation of metabolomes from microorganisms of mesophilic soil of Rajasthan, India

Significance and potential of marine microbial natural bioactive compounds against biofilms/biofouling: necessity for green chemistry

The Essentials of Marine Biotechnology

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