Isolation and Characterization of Limonoids from Kigelia africana

Jabeen, Bushra; Riaz, Naheed

doi:10.5560/znb.2013-3096

Cited by 15 publications

(11 citation statements)

References 18 publications

(24 reference statements)

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“…There is a widespread effort to find new AChE inhibitors from natural source, but not much work has focused on limonoid compounds. Our compounds had a much higher anti- AChE activity than the limonoids from Kigelia africana (Bignoniaceae) with IC 50 values in the ranges 137.5–225.2 μM [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

et al. 2015

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Background Limonoids are highly oxygenated compounds with a prototypical structure. Their occurrence in the plant kingdom is mainly confined to plant families of Meliaceae and Rutaceae. Owing to their wide range of pharmacological and therapeutic properties, this study was aimed at investigating the potential nitric oxide (NO) and acetylcholinesterase (AChE) inhibitory activity and the cytotoxicity of three limonoids: trichilia lactone D5 (1), rohituka 3 (2) and dregeanin DM4 (3), isolated from Trichilia welwitschii C.DC.ResultsResults indicated that the three limonoids had low cytotoxicity towards Vero cells with LC50 values ranging from 89.17 to 75.82 μg/mL. Compounds (2) and (3) had lower cytotoxicity compared to puromycin and doxorubicin used as reference cytotoxic compounds. Compound (1) (LC50 of 23.55 μg/mL) had good antiproliferative activity against RAW 264.7 cancer cells. At the lowest concentration tested (0.5 µg/mL), compound (2) and (3) released the lowest amount of nitric oxide (2.97 and 2.93 µM, respectively). The three limonoids had anti-AChE activity with IC50 values ranged of 19.13 μg/mL for (1), 34.15 μg/mL for (2) and 45.66 μg/mL for (3), compared to galantamine (IC50 of 8.22 μg/mL) used as positive control.ConclusionThe limonoid compounds studied in this work inhibited nitric oxide production in LPS-stimulated macrophages and had anti-AChE activity. Trichilia lactone D5 had potential antiproliferative activity against RAW 264.7 cancer cells. The limonoids had low cytotoxicity towards Vero cells lines. This study provided further examples of the importance of limonoids compounds as potential AChE inhibitors and anti-inflammatory agents targeting the inhibition of NO production.

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Section: Resultsmentioning

confidence: 99%

Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

et al. 2015

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“…Dysoxylum mollissimum is the source of the AB-cleaved limonoids dysoxylumasins A 379 -F 384. 174 The 178 The structure of deacetyl-2α-methoxykhayanolide E 420 was confirmed by X-ray analysis. …”

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confidence: 86%

Triterpenoids

Hill

Connolly

2017

Nat. Prod. Rep.

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“…Bignonia species exhibited various biological activities including; cytotoxic [54] antiprotozoal [51], analgesic [55], insect repellant [15], anti-inflammatory [37] and cholinergic activities [43] as demonstrated in (Table 3).…”

Section: Biological Activities Of Genus "Bignonia"mentioning

confidence: 99%

Phytochemical and biological overview of genus "Bignonia" (1969-2018)

Mahmoud

Hamed

Samy

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Bignonia L. is the fifth largest genus in the tribe Bignonieae, with 31 lianas species. Bignonia plants are widely used in traditional medicine as skin ailments like fungal infections, postpartum haemorrhage, malaria, diabetes and pneumonia. Many literature reported that Bignonia species contained different classes of active constituents as phenylethanoids, phenolics, lignans, flavonoids, coumarins and xanthones. Additionally, they demonstrated a wide range of biological activities as cytotoxic, wound healing, antidiabetic, sleep induction, gastroprotection, anti-obesity and insecticidal activities. This review revealed that only 15 species have been reported in the literature. Moreover, Bignonia plants need further studies as they are considered a good source for bioactive natural products.

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Isolation and Characterization of Limonoids from Kigelia africana

Cited by 15 publications

References 18 publications

Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

Cytotoxicity, nitric oxide and acetylcholinesterase inhibitory activity of three limonoids isolated from Trichilia welwitschii (Meliaceae)

Triterpenoids

Phytochemical and biological overview of genus "Bignonia" (1969-2018)

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