Isolation and characterization of hemagglutinating noninfectious particles produced during multiplication of Newcastle disease virus (NDV)

The ultrastructure of canine distemper virus

“…Influenza virus filaments have been shown to have a surface structure similar to that of the intact virus particle (17) and of special interest is that a similar type of particles has been shown to be present in tissue culture preparations of rinderpest virus (4). Doughnut-like particles similar to those shown here but of a smaller size have been found in Newcastle disease virus preparations by Rottet al (18). They leave the question open about their nature and origin.…”

Isolation and Characterization of Defective Interfering Particle of Newcastle Disease Virus

“…The results of test for biological activities indicated. B particles to be normal active virus and T particles to be noninfectious hemagglutinating (NIH) viral particles reported previously by several workers (3,7,13,14). Although T particles were morphologically similar to B particles, T particles were significantly smaller than B particles as reported previously with NIH particles (3).…”

“…Newcastle disease virus (NDV) produced in embryonated eggs has been reported to consist of two distinct types of particles, i.e. infectious hemagglutinating (IH) and non-infectious hemagglutinating (NIH) particles (3,7,13,14). In contrast to IH particles which are normal and fully active virus, NIH particles are smaller (3), non-hemolytic (1), deficient in viral RNA (13) and do not show interference of von Magnus type (3,14).…”

“…infectious hemagglutinating (IH) and non-infectious hemagglutinating (NIH) particles (3,7,13,14). In contrast to IH particles which are normal and fully active virus, NIH particles are smaller (3), non-hemolytic (1), deficient in viral RNA (13) and do not show interference of von Magnus type (3,14). In the present study, NIH particles were separated and purified from NDV produced in chick embryos, and their biological properties were investigated.…”

Structure and Development of Viruses as Observed in the Electron Microscope

“…As previously mentioned, incomplete fowl plague virus closely resembles incomplete influenza virus, and recent evidence suggests that the same may be true for Newcastle disease virus (56). It is tempting to speculate that incom-plete virus may be associated not only with other myxoviruses but also with those viruses which, although unrelated to influenza virus, appear to share in common a mechanism whereby surface components are acquired during differentiation at, or passage through, the cellular wall.…”