Isolation and characterization of gum from &lt;i&gt;Chrysophyllum albidum&lt;/i&gt; fruits as pharmaceutical excipient

Bakre, Lateef Gbenga; Osideko, Adejoke O.; Bamiro, Oluyemisi Adebowale

doi:10.4314/jpb.v14i1.3

Cited by 4 publications

(9 citation statements)

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“…D I (1-a) which is the initial packed relative density of the tablets pressure when small pressure is applied was obtained. Pk is derived from the reciprocal of b and it represents the pressure required to reduce the powder bed by 50 % 16 .…”

Section: Kawakita Plotmentioning

confidence: 99%

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Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide

Bakre¹,

Osibajo²,

Koiki³

et al. 2019

actapharm

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This study aims to co-process native Ipomea batatas starch (NPS) with colloidal silicon dioxide and evaluate the properties of the co-processed excipient (CPS). The powder morphology was determined by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-Ray Diffraction (XRD) measurements. The compressional, mechanical and release properties of metronidazole tablet formulations were evaluated. NPS was predominantly oval in shape while CPS had more large truncated ellipsoidal granules. Both NPS and CPS exhibited spectra typical of a Type A XRD pattern, but CPS has a sharp peak with strong intensity at 27 0 2q which was absent in NPS. Although NPS had a faster onset of plastic deformation, the overall amount of plastic deformation was higher in CPS. Tablets formulated with CPS had faster dissolution than those containing similar concentration of NPS. The co-processing of Ipomea batatas starch with colloidal silicon dioxide resulted in modification of its powder and tableting properties.

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Section: Kawakita Plotmentioning

confidence: 99%

“…Py gives an indication of the plasticity and softness of the materials. A low value shows low resistance to pressure, good densification and fast onset of plastic deformation 16 . The rank order of Py is DCP<NPS<MCC<CPS.…”

Section: Physicochemical and Compressional Propertiesmentioning

confidence: 99%

Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide

Bakre¹,

Osibajo²,

Koiki³

et al. 2019

actapharm

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“…The true density of the samples was determined using the fluid displacement method [11]. The bulk density of each sample was obtained by pouring 10 g of the gum at angle of 45 0 into a 50 ml measuring cylinder and the volume occupied was recorded.…”

Section: Density Measurementsmentioning

confidence: 99%

“…The moisture content was determined by gravimetric method [11]. To determine the foaming capacity, 1 g of sample was weighed into 20 ml distilled water and shaken for 30 minutes.…”

Section: Determination Of Moisture Content and Foaming Capacitymentioning

confidence: 99%

“…It is seasonal (usually from December to March) and the fleshy fruit pulp is suitable for jams. Chrysophyllum albidum gum extracted from the fruit had been characterized, used as binder and employed as polymer in sustained release formulation [10][11][12][13]. However, it appears little or no work has been done on studying the effect of cross-linking on the properties of the gum and its tablet formulation.…”

Section: Introductionmentioning

confidence: 99%

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Crosslinking of Chrysophyllum albidum gum with calcium chloride to enhance its physicochemical, compressional and tableting properties

Bakre¹,

Akinsanya²

2019

jrp

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Development and evaluation of gastroretentive ciprofloxacin floating tablets using Chrysophyllum albidum gum

Bakre

Ladele

2019

Pharmacy Practice and Res

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Background: The floating drug delivery system offers immense advantages for the controlled delivery of drugs because it increases gastric residence time and thereby improves drug bioavailability. Aim: The aim of this study was to design a gastroretentive drug delivery system for controlled delivery of ciprofloxacin using Chrysophyllum albidum gum (CAG) in combination with hydrophilic polymers such as xanthan gum (XG) and hydroxypropyl methylcellulose (HPMC). Methods: Floating tablets prepared by the effervescence method and direct compression were evaluated for hardness, friability, swelling index, floating lag time and total floating time. In vitro drug release data were fitted into different drug release kinetic models, and the mechanism of drug release was determined. Results: The tablets exhibited satisfactory physicochemical characteristics, showed good in vitro buoyancy and swelled considerably. Tablets with a higher amount of CAG floated for a longer duration and had more matrix integrity than formulations containing lower amounts of CAG. The optimised formulation exhibited 50% and 90% drug release in 6.5 and 11.5 h, respectively, which suggests a sustained release effect, whereas the buoyancy lag time was 18 s. Analysis of the in vitro release kinetics suggests that the drug was released from the optimised formulation by diffusion, and the drug release mechanism was observed to be Fickian diffusion.Conclusion: This study highlights the potential of a ciprofloxacin floating system prepared from xanthan gum, HPMC and CAG as a suitable alternative to the conventional dosage and other sustained-release formulations.

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Isolation and characterization of gum from <i>Chrysophyllum albidum</i> fruits as pharmaceutical excipient

Cited by 4 publications

References 0 publications

Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide

Material, compressional and tableting properties of ipomea batatas (sweet potato) starch co-processed with silicon dioxide

Crosslinking of Chrysophyllum albidum gum with calcium chloride to enhance its physicochemical, compressional and tableting properties

Development and evaluation of gastroretentive ciprofloxacin floating tablets using Chrysophyllum albidum gum

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