Isolation and Characterization of Genes Differentially Expressed in Early Drosophila Embryogenesis

Lengyel, Judith A.; Thomas, Steven R.; Boyer, Paul D.; Salas, Fidel; Strecker, Teresa R.; Lee, Inyong; Graham, Melissa; Roark, Margaret; Underwood, Eileen M.

doi:10.1007/978-1-4684-4628-9_10

Molecular Aspects of Early Development 1984

DOI: 10.1007/978-1-4684-4628-9_10

|View full text |Cite

Isolation and Characterization of Genes Differentially Expressed in Early Drosophila Embryogenesis

Judith A. Lengyel¹,

Steven R. Thomas²,

Paul D. Boyer³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1988

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.

Eberl

Hilliker²

1988

Genetics

View full text Add to dashboard Cite

This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screening criterion. Of 800 EMS-induced lethal mutations analyzed, only 14% were embryonic lethal, and of these only a minority affected embryonic morphogenesis. By recombination and complementation analyses, the mutations that affected embryonic morphogenesis were sequestered into 26 complementation groups. Fourteen of the loci correspond to genes previously identified in a large-scale screen in which fixed cuticles were examined, and 12 new loci have been identified. Most of the mutations which disrupt embryonic morphology had specific and uniform mutant phenotypes. Mutations were recovered which disrupt major morphogenetic events such as gastrulation, germ band retraction and head involution. No mutations were found which arrest the embryos prior to blastoderm formation. However, a novel class was found, one comprised of mutations which interfere with the development of internal structures but not cuticular structures. Nevertheless, saturation of the X chromosome for genes important for embryonic morphogenesis is probably incomplete.

show abstract

Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.

Eberl

Hilliker²

1988

Genetics

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Isolation and Characterization of Genes Differentially Expressed in Early Drosophila Embryogenesis

Cited by 1 publication

References 65 publications

Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.

Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster.

Contact Info

Product

Resources

About