Isolation and Characterization of Full Length cDNA Coding for the H23 Breast Tumor Associated Antigen

The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms

“…3,[10][11][12][13][14][24][25][26] MUC1 is a membrane-associated glycoprotein, consisting of three distinct domains: (1) an amino-terminal region containing a hydrophobic signal sequence and degenerated tandem repeats; (2) around 30 to 90 almost conserved tandem repeats of 20 amino acids; and (3) a carboxyl-terminal region containing degenerate repeats, a membrane spanning region of 31 amino acids, and a cytoplasmic tail of 69 amino acids. 15,[27][28][29][30][31][32] Soluble forms of MUC1 that lack the cytoplasmic tails have been reported. The MUC1 mucin mRNA is detected in most epithelial tissues, 33 and high levels of expression are seen in breast and pancreas.…”

MUC1 isoform specific monoclonal antibody 6E6/2 detects preferential expression of the novel MUC1/Y protein in breast and ovarian cancer

“…Monoclonal antibodies directed against cell surface proteins which are overexpressed in epithelial tumor tissues may serve as important tools for diagnosis and immunotherapy. Our laboratory has focused on the products of the MUC1 gene, some of which are polymorphic high molecular‐mass glycoproteins abundantly expressed in human breast carcinomas (Swallow et al, 1987; Wreschner et al, 1989; Keydar et al, 1989; Gendler et al, 1990; Ligtenberg et al, 1990; Tsarfaty et al, 1990; Wreschner et al, 1990; Baruch et al, 1997). Poor prognosis in breast cancer patients correlates with increased MUC1 gene expression and the MUC1 proteins can thus be considered to be tumor markers (Hayes et al, 1991).…”