2006
DOI: 10.1016/j.peptides.2006.03.033
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Isolation and characterization of four antibacterial peptides from bovine hemoglobin

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Cited by 78 publications
(47 citation statements)
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“…Turning to blood proteins as sources of anti-bacterial peptides is, therefore, justified and a number of researchers have investigated the anti-bacterial properties of peptides isolated from animal blood. Nedjar-Arroume and others [129] identified four antibacterial peptides in bovine hemoglobin. The total hemoglobin isolate obtained by peptic hydrolysis was found to inhibit the microorganisms Micrococcus luteus, Listeria innocua, Escherichia coli, and Salmonella enteritidis.…”
Section: Bioactive Compoundsmentioning
confidence: 99%
See 1 more Smart Citation
“…Turning to blood proteins as sources of anti-bacterial peptides is, therefore, justified and a number of researchers have investigated the anti-bacterial properties of peptides isolated from animal blood. Nedjar-Arroume and others [129] identified four antibacterial peptides in bovine hemoglobin. The total hemoglobin isolate obtained by peptic hydrolysis was found to inhibit the microorganisms Micrococcus luteus, Listeria innocua, Escherichia coli, and Salmonella enteritidis.…”
Section: Bioactive Compoundsmentioning
confidence: 99%
“…Given the current context of food safety, protection utilizing natural products as preservatives could be beneficial for safe storage and distribution of meat products [129], which are often responsible for outbreaks of foodborne diseases. This is particularly important as some of the proposed means of addressing food-borne diseases such as irradiation are unacceptable for many consumers, who are increasingly demanding natural products.…”
Section: Bioactive Compoundsmentioning
confidence: 99%
“…Adicionalmente, verificou-se que as subunidades α e β da hemoglobina de diversos vertebrados apresentam atividade contra bactérias Gram-positivas, Gram-negativas e fungos (Parish et al, 2001) e, nos últimos 10 anos, vários trabalhos têm descrito a atividade antimicrobiana de peptídeos derivados da hidrólise química ou enzimática de hemeproteínas (Froidevaux et al, 2001;Liepke et al, 2003;Mak et al, 2004;Daoud et al, 2005;Nedjar-Arroume et al, 2006;Nedjar-Arroume et al, 2008). Tais peptídeos an-timicrobianos passaram a ser coletivamente denominados hemocidinas (Mak et al, 2000).…”
Section: Hemoglobina Como Fonte De Peptídeos Bioativosunclassified
“…Desde que, com a colaboração de nosso grupo de pesquisa, um peptídeo com atividade antimicrobiana foi isolado do conteúdo intestinal do carrapato Boophilus microplus e sua seqüência mostrou 100% de identidade com a seqüência 33-61 da cadeia α da hemoglobina bovina (Hb33-61;FOGAÇA et al, 1999), outros grupos relataram a geração de fragmentos da hemoglobina in vivo (NAKAJIMA et al, 2003, MAK et al, 2004, SONENSHINE, 2005, NEDJAR-ARROUME et al, 2006 e in vitro (FROIDEVAUX et al, 2001, PARISH et al, 2001LIEPKE et al, 2003;DAOUD et al, 2005). Anteriormente, já era bem estabelecido que fragmentos desta proteína apresentam funções biológicas variadas, tais como: ação opióide, imunomodulação e atividade liberadora de hormônios (IVANOV et al, 1997).…”
Section: Fragmento 33-61 Da Cadeia α Da Hemoglobina Bovinaunclassified
“…A atividade antimicrobiana de um fragmento de hemoglobina foi descrita pela primeira vez em 1999 (FOGAÇA et al, 1999) e posteriormente, por outros grupos (NAKAJIMA et al, 2003;MAK et al, 2004;SONENSHINE, 2005, NEDJAR-ARROUME et al, 2006.…”
Section: Ensaios Biológicosunclassified