Isolation and characterization of biologically active glycosides from endemic Cephalaria species in Anatolia

Sarikahya, Nazli Boke; Pekmez, Murat; Arda, Nazlı; Kayce, Peyker; Yavaşoğlu, Nefise Ülkü Karabay; Kirmizigul, Suheyla

doi:10.1016/j.phytol.2011.05.006

Cited by 23 publications

(15 citation statements)

References 26 publications

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“…After the comparison with chemical standard, 15 was identified as loganin. Loganin was previously confirmed in Cephalaria elaziginesis , Cephalaria kotschyi and Cephalaria isaurica [ 27 , 46 , 48 ]. Compounds 8 , 16 – 20 and 29 were tentatively classified as other iridoids based on UV-Vis maxima observed at ca.…”

Section: Resultsmentioning

confidence: 94%

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

et al. 2020

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The aim of this study was to compare the chemical composition, as well as antioxidant, anti-inflammatory, antiacne, and cytotoxic activites of various extracts of Cephalaria gigantea and C. uralensis. It is worth underlining that we are the first to characterize the composition and evaluate the biological properties of extracts from Cephalaria gigantea and C. uralensis. Thus, the LC-DAD-MS3 analysis revealed the presence of 41 natural products in studied extracts. The 5-O-caffeoylquinic acid, isoorinetin, and swertiajaponin were the main detected compounds. Among the tested samples, ethanol extract of the aerial parts of C. uralensis (CUE) possessed the most suitable biological properties. It exhibited moderate ability to scavenge free radicals and good capacity to inhibit cyclooxygenase-1, as well as cyclooxygenase-2. Moreover, CUE possessed moderate antibacterial activity against all tested bacterial strains (S. aureus, S. epidermidis, and P. acnes), and importantly, it was non-toxic towards normal skin fibroblasts. Taking into account the value of calculated therapeutic index (>10), it is worth noting that CUE can be subjected to in vivo study. Thus, CUE constitutes a very promising antiacne agent.

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Section: Resultsmentioning

confidence: 94%

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

et al. 2020

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“…In spruce needles picein and piceol concentrations have been 1.8-2.2% and 0.4-1.1% of dry weight (Turtola et al 2006;Stolter et al 2009). The antimicrobial potential of the isolated picein has been examined and it has been found to exhibit activity against both Gram-positive and Gram-negative bacteria (S. aureus, S. epidermidis, S. typhimurium, E. coli, B. cereus, K. pneumoniae, E. faecalis, and P. aeruginosa) with MIC values ranging from 16 to 64 mg L -1 (Table 1) (Sarıkahya et al 2011).…”

Section: Antibacterial Activity Of Small Phenolic Compoundsmentioning

confidence: 99%

Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

2019

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Phenolics and extracted phenolic compounds of Scots pine (Pinus sylvestris) and Norway spruce (Picea abies) show antibacterial activity against several bacteria. The majority of phenolic compounds are stilbenes, flavonoids, proanthocyanidins, phenolic acids, and lignans that are biosynthesized in the wood through the phenylpropanoid pathway. In Scots pine (P. sylvestris), the most abundant phenolic and antibacterial compounds are pinosylvin-type stilbenes and flavonol-and dihydroflavonol-type flavonoids, such as kaempferol, quercetin, and taxifolin and their derivatives. In Norway spruce (P. abies) on the other hand, the main stilbene is resveratrol and the major flavonoids are quercetin and myricetin. In general, when the results from the literature regarding the activities of flavonoid glycosides and their aglycones against a total of twenty-one microorganisms are summarized, it was found that phenolic glycosides are less active than the corresponding aglycones, although a number of exceptions are also known. The aglycones in plants respond to various kinds of biotic stress. Synergistic effects between aglycones and their glycosides have been observed. Minimum inhibition concentrations of below 10 mg L-1 against bacteria have been reported for gallic acid, apigenin, and several methylated and acylated flavonols present in these industrially important trees. In general, the phenolic compounds are more active against Gram-positive bacteria, but apigenin is reported to exhibit strong activity against Gram-negative bacteria. The present review lists some of the biosynthesis pathways for the antibacterial phenolic metabolites found in Scots pine (P. sylvestris) and Norway spruce (P. abies). The antimicrobial activity of the compounds is collected and compared to gather information about the most effective secondary metabolites.

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“…Moreover, they are used in veterinary medicine and agriculture, as a wool dye and as an additive to bread [ 34 , 35 ]. Literature studies have shown that the Cephalaria species contain flavonoids [ 17 , 36 , 37 ], triterpenoid saponins [ 36 , 38 , 39 , 40 ], iridoids [ 36 , 37 , 40 ], alkaloids [ 37 , 41 , 42 , 43 ], lignans [ 37 , 44 ], fatty acids [ 45 , 46 ], that exhibit antioxidant, antimicrobial, cytotoxic, hemolytic, and immunomodulating activities [ 3 , 18 , 27 , 31 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Composition and Antioxidant Activity of Plants Belonging to the Cephalaria (Caprifoliaceae) Genus

Chrząszcz

Krzemińska

Skowronek

et al. 2021

Plants

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The genus Cephalaria, belonging to the Caprifoliaceae family, is a rich source of interesting secondary metabolites, including mainly saponins which display a variety of biological activities, such as immunomodulatory, antimicrobial and hemolytic effects. Besides these compounds, flavonoids and phenolic acids were identified in Cephalaria species. Cephalaria is employed in traditional medicine e.g., to cure cardiac and lung diseases, rheumatism, and regulate menstruation. In this review we focus on the phenolic compound composition and antioxidative activity of Cephalaria species. The antioxidant effect can be explained by flavonoids present in all parts of these plants. However, future efforts should concentrate more on in vitro and in vivo studies and also on clinical trials in order to confirm the possibility of using these plants as natural antioxidants for the pharmacology, food or cosmetic industries.

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Isolation and characterization of biologically active glycosides from endemic Cephalaria species in Anatolia

Cited by 23 publications

References 26 publications

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation

Bioactive phenolic compounds, metabolism and properties: a review on valuable chemical compounds in Scots pine and Norway spruce

Phenolic Composition and Antioxidant Activity of Plants Belonging to the Cephalaria (Caprifoliaceae) Genus

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