Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (<i>Papaver somniferum</i>)

Bulduk, İbrahim; Taktak, Fulya

doi:10.1155/2013/493870

Cited by 11 publications

(10 citation statements)

References 11 publications

(13 reference statements)

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“…All the signals of 1 appear to be broad peaks in DMSO-d6, possibly due to chemical exchange. The chemical shifts and integration of peaks agree with previous reported NMR data of 1 (refs 72 , 73 ). HRMS ( m / z ): [M+H] + calcd.…”

Section: Methodssupporting

confidence: 91%

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

2016

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Noscapine is a potential anticancer drug isolated from the opium poppy Papaver somniferum, and genes encoding enzymes responsible for the synthesis of noscapine have been recently discovered to be clustered on the genome of P. somniferum. Here, we reconstitute the noscapine gene cluster in Saccharomyces cerevisiae to achieve the microbial production of noscapine and related pathway intermediates, complementing and extending previous in planta and in vitro investigations. Our work provides structural validation of the secoberberine intermediates and the description of the narcotoline-4′-O-methyltransferase, suggesting this activity is catalysed by a unique heterodimer. We also reconstitute a 14-step biosynthetic pathway of noscapine from the simple alkaloid norlaudanosoline by engineering a yeast strain expressing 16 heterologous plant enzymes, achieving reconstitution of a complex plant pathway in a microbial host. Other engineered yeasts produce previously inaccessible pathway intermediates and a novel derivative, thereby advancing protoberberine and noscapine related drug discovery.

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Section: Methodssupporting

confidence: 91%

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

2016

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“…Previously, it has shown antitumor and cough suppressant properties [39]. Recently, it was isolated from dried capsules of Papaver somniferum L, which belongs to the family Papaveraceae [40]. Deoxypeganine is an alkaloid isolated from medicinal herb Peganum harmala L, which belongs to the family Zygophyllaceae.…”

Section: Resultsmentioning

confidence: 99%

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells

Abbas¹,

Al-Harrasi²,

Hussain³

et al. 2017

ijpm

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A b s t r a c tThis study was performed to identify new inhibitors of protein glycation glycation is one of the major causes of late diabetic complications. In this study, terpenoids and alkaloids, isolated from different medicinal plants, along with their derivatives, were evaluated for their antiglycation activity to assess their potential cytotoxicity. Among the tested compounds, gossypol (2,2 1,6,7 and its derivat gazolidone (6), showed a potent antiglycation activity (IC aminoantipyrine (5) showed a significant antiglycation activity with IC µM, in BSA methyl isolated from aphyllin significant inhibition activity with 110.203±4.816µM, respectively. Similarly, compounds gossypol deoxypeganine hydrochloride (8), with IC respectively. The results were compared with the = Cellular cytotoxicity assay showed only gossypol acetic acid (2) and gossypolidene thiocarbamide (3) as somewhat toxic to 3T3 (mouse fibroblast) cells with IC ±0.61 and 5.00 with IC

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“…Terpenoids have numerous medicinal activities including anti-oxidant, anti-cancer, anti-bacterial, anti-inflammatory, and anti-viral effects through inhibition of virus proteases [125]. Noscapine (NOS) is a natural phthalideisoquinoline alkaloid that is extracted from the opium poppy, Papaver somniferum of the Papaveraceae family.…”

Section: Noscapinementioning

confidence: 99%

Pharmacological treatments of COVID-19

et al. 2020

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The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19), which was reported for the first time in December 2019, was named by the World Health Organization (WHO) as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2), because of the very similar genome and also its related symptoms to SARS-CoV1. The ongoing COVID-19 pandemic with significant mortality, morbidity, and socioeconomic impact is considered by the WHO as a global public health emergency. Since there is no specific treatment available for SARS-CoV2 infection, and or COVID-19, several clinical and sub-clinical studies are currently undertaken to find a gold-standard therapeutic regimen with high efficacy and low side effect. Based on the published scientific evidence published to date, we summarized herein the effects of different potential therapies and up-to-date clinical trials. The review is intended to help readers aware of potentially effective COVID-19 treatment and provide useful references for future studies.

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Isolation and Characterization of Antitumor Alkaloid from Poppy Capsules (Papaver somniferum)

Cited by 11 publications

References 11 publications

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

Identification of natural products and their derivatives as promising inhibitors of protein glycation with non-toxic nature against mouse fibroblast 3T3 cells

Pharmacological treatments of COVID-19

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