Isolation and characterization of Anthraquinone from Streptomyces sp. ERINLG-26 with anticancer activity Against adenocarcinoma cell line COLO320

Balachandran, C.; Duraipandiyan, Veeramuthu; Al-Dhabi, N. A.; Stalin, Antony; Balakrishna, K.; Ignacimuthu, S.; Tilton, Florida

doi:10.1134/s0003683815050038

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Many naphthalene-based natural products have been isolated from different sources and showed significant biological activities. [66]. 2-hydroxy-9,10-anthraquinone showed cytotoxic activity against A549 lung and COLO320 cells lines and it showed 62.7% activity at the dose of 500 μg mL −1 with IC 50 value of 400 μg mL −1 against COLO320 cells [67].…”

Section: Naphthalenes and Their Cytotoxic Activitiesmentioning

confidence: 96%

“…Also, COX-2 enzyme plays a major role in colorectal cancer and significantly reduced COX-2 enzyme in COLO320 cells. the over expression gene during the colorectal cancer [66]. Chrysophanol 8-O-beta-(6′-acetyl) glucopyranoside exhibited relatively higher cytotoxic activities against human oral squamous cell carcinoma HSC-2 and salivary gland tumor HSG cell lines than against normal human gingival fibroblasts HGF cells lines [69] (Figure 4).…”

Section: Naphthalenes and Their Cytotoxic Activitiesmentioning

confidence: 99%

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Phenolic Compounds from the Natural Sources and Their Cytotoxicity

Perveen¹,

Al‐Taweel²

2017

Phenolic Compounds - Natural Sources, Importance and Applications

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Natural phenolic compounds are considered as one of the important secondary metabolites for their chemopreventive and chemotherapeutic effects in cancer. These compounds show potent activities for cancer prevention and its treatment. There are many phenolic compounds present in medicinal and edible plants such as, flavonoids, bioflavonoids, stilbenes, chalconoids, chromones, phenylpropanoids, curcuminoids, coumarins, tannins, lignans, neolignans, anthraquinones, quinones, xanthones, phenolic acids and their glycosides and many more. The antioxidant potential of phenolic compounds is almost bolded in the treatment and prevention of cancer. Mono phenolic, polyphenolic and phenolic acids compounds from a large variety of plants, foods, spices, insects, fungus, beverages, lichens, algae and mammals have been shown to inhibit or attenuate the initiation, progression and spread of cancers in cells in vitro and in animals in vivo. In this chapter, we try to cover general view and the recent literature to summarize structural information and cytotoxic effects of phenolic compounds on different cancer cell lines from medicinal herbs and plants.

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Section: Naphthalenes and Their Cytotoxic Activitiesmentioning

confidence: 96%

Section: Naphthalenes and Their Cytotoxic Activitiesmentioning

confidence: 99%

Phenolic Compounds from the Natural Sources and Their Cytotoxicity

Perveen¹,

Al‐Taweel²

2017

Phenolic Compounds - Natural Sources, Importance and Applications

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“…Chemical structure of nordamnacanthal (1), damnacanthal (2), 1,3,5-dihydoxy-2-methoxy-6-methyl anthraquinone (3), morindone (4), sorendidiol (5), rubiadin (6), damnacanthol (7) and lucidin-ωmethyether (8).…”

Section: Declarationsmentioning

confidence: 99%

Morindone From Morinda Citrifolia as a Potential Antiproliferative Agent Against Colorectal Cancer Cell Lines

Chee

Zamakshshari

Lee

et al. 2021

Preprint

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There is an increasing demand in developing new, effective, and affordable anti-cancer against colon and rectal. In this study, our aim is to identify the potential anthraquinone compounds from the root bark of Morinda citrifolia to be tested in vitro against colorectal cancer cell lines. Eight potential anthraquinone compounds were successfully isolated, purified and tested for both in-silico and in-vitro analyses. Based on the in-silico prediction, two anthraquinones, morindone and rubiadin, exhibit a comparable binding affinity towards multitargets of β-catenin, MDM2-p53 and KRAS. Subsequently, we constructed a 2D interaction analysis based on the above results and it suggests that the predicted anthraquinones from Morinda citrifolia offer an attractive starting point for potential antiproliferative agents against colorectal cancer. In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines.

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“…The class of anthraquinone compounds has cytotoxic activity on colon cancer cells COLO 320 through the activation mechanism of p53 protein, p53 protein will increase the expression of proapoptotic protein families such as Bax and suppress the expression of antiapoptotic proteins such as Bcl-2 which will induce apoptosis [28]. The process of occurrence apoptosis can occur through two lines of the pathway, from the cell outside (extrinsic) and from the mitochondrial stress (intrinsic).…”

Section: Advances In Health Sciences Research Volumementioning

confidence: 99%