Isolation and Characterization of an Enteric Reovirus Causing High Mortality in Turkey Poults

Simmons, Donald G.; Colwell, W. M.; Muse, Kenneth E.; Brewer, Charles E.

doi:10.2307/1588834

Cited by 34 publications

(14 citation statements)

References 5 publications

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“…Furthermore, the ability of these viruses to replicate in intestinal tissue is poor, as evidenced by only rare detection of virus in intestinal tissue after experimental inoculation, which differs from some previous reports where reovirus replicated well in the intestine (Simmons et al ., 1972;Nersessian et al ., 1985) and may be a strain-specific characteristic.…”

Section: Discussioncontrasting

confidence: 77%

“…Reovirus infections in turkeys, often in flocks experiencing enteritis, have been reported previously (Simmons et al ., 1972;Reynolds et al ., 1987;Lozano et al ., 1989;Heggen-Peay et al ., 2002). However, the role of reovirus in disease induction has not been clearly established as the virus can be found in specimens from healthy flocks and it is not uncommon to detect other enteric viruses in the same specimens (Dees et al ., 1972).…”

Section: Discussionmentioning

confidence: 56%

“…While most reports focus on disease in chickens, clinical disease in turkeys has been reported to be similar to what is observed in chickens, and includes viral arthritis (Page et al ., 1982) and poult enteritis (Dees et al ., 1972;Simmons et al ., 1972;Gershowitz & Wooley, 1973;Reynolds et al ., 1987;Lozano et al ., 1989;Heggen-Peay et al ., 2002). Historically, it has been assumed that all avian reoviruses from chickens and turkeys are closely related.…”

Section: Introductionmentioning

confidence: 99%

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The pathogenesis of turkey origin reoviruses in turkeys and chickens

et al. 2005

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Section: Discussioncontrasting

confidence: 77%

Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

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The pathogenesis of turkey origin reoviruses in turkeys and chickens

et al. 2005

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“…So far the described cases of infection include chickens (Olson et al 1972), turkeys (Palya et al 2003), geese (Simmons et al 1972), ducks (Maliknson et al 1981) and other species. The clinical symptoms caused by ARV in chickens include respiratory or enteric disease, viral arthritis or runting-stunting syndrome (RSS) (Simmons et al 1972). The lesions are described as inclusion body hepatitis, necrotic foci in liver, splenomegaly and hydropericardium.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of reovirus infection in Muscovy ducks (Cairina moschata) in south western Poland

Woźniakowski¹,

Samorek-Salamonowicz²,

Gaweł³

2014

Polish Journal of Veterinary Sciences

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During the summer 2012 an incidence of high mortality, above 44 percent, in two flocks of Muscovy ducklings in Poland was noted. The clinical signs included considerable weight loss and inability to walk.During the post-mortem evaluations dehydration and enteritis, gouty kidneys as well as hemorrhagic liver and spleen lesions were found. The laboratory diagnosis included agar gel precipitation assay (AGP) as well as polymerase chain reaction (PCR) or reverse transcription PCR for the presence of goose parvovirus (GPV), duck circovirus (DuCV), duck reovirus (DRV) and avian reovirus (ARV). Interestingly, the examinations performed by AGP showed partial reactivity of liver homogenates from Muscovy ducklings with chicken S1133 antiserum. The presence of duck reovirus RNA was also detected by real-time RT-PCR targeting the chicken reovirus sigma NS fragment, while the sequencing showed major similarity to chicken S1133, 1733, GX/2010/1 and TARV-MN2 reovirus strains. The virus sequence was also related to a previously isolated TH11 strain from Muscovy ducks in China.Further study is needed in order to explain the particular epidemiology of the reovirus infection of Muscovy ducklings.

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“…1,3,4,[8][9][10][11]21,25,31,38,47,50 Avian reoviruses have also been associated with immunosuppression 24,40 and atrophy of the bursa of Fabricius with characteristic lymphoid depletion and proliferation of connective tissue. 23,24,27,29,36,38,48 Studies in turkeys involving experimental reovirus infection have produced viral arthritis 2,19,30 and poult enteritis, 7,9,20,26,35,42 although descriptions of microscopic lesions caused by turkey-origin reoviruses (TRVs) are limited.…”

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confidence: 99%

Pathology and Virus Tissue Distribution of Turkey Origin Reoviruses in Experimentally Infected Turkey Poults

2007

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Abstract. The pathogenesis of 4 isolates of turkey-origin reovirus (NC/SEP-R44/03, NC/98, TX/98, and NC/85) and 1 chicken-origin reovirus (1733) was examined by infecting specific pathogen free (SPF) poults. These turkey-origin reovirus (TRV) isolates were collected from turkey flocks experiencing poult enteritis and are genetically distinct from previously reported avian reoviruses. Microscopic examination of the tissues collected from the TRV-infected poults revealed different degrees of bursal atrophy characterized by lymphoid depletion and increased fibroplasia between the bursal follicles. To understand the relationship between virus spread and replication, and the induction of lesions, immunohistochemical staining (IHC) for viral antigen, in situ hybridization (ISH) for the detection of viral RNA, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for the detection of apoptosis in affected tissues was performed. Both IHC and ISH revealed viral antigen and RNA in the surface epithelial cells of the bursa, in macrophages in the interstitium of the bursa and, to lesser degree, in splenic red pulp macrophages and intestinal epithelial cells. Increased apoptosis of bursal lymphocytes and macrophages was observed at 2 and 5 days postinoculation. No lesions were found in tissues from poults inoculated with the virulent chicken-origin strain, however viral antigen was detected in the bursa and the intestine. Although all TRVs studied displayed similar tissue tropism, there were substantial differences in the severity of the lesions produced. Poults inoculated with NC/SEP-R44/03 or NC/98 had moderate to severe bursal atrophy, whereas poults inoculated with TX/ 98 or NC/85 presented a mild to moderate bursal lymphoid depletion. The lymphoid depletion observed in the bursa appears to be the effect of an indirectly induced apoptosis and would most likely result in immune dysfunction in poults infected with TRV.

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Isolation and Characterization of an Enteric Reovirus Causing High Mortality in Turkey Poults

Cited by 34 publications

References 5 publications

The pathogenesis of turkey origin reoviruses in turkeys and chickens

The pathogenesis of turkey origin reoviruses in turkeys and chickens

Occurrence of reovirus infection in Muscovy ducks (Cairina moschata) in south western Poland

Pathology and Virus Tissue Distribution of Turkey Origin Reoviruses in Experimentally Infected Turkey Poults

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