Isolation and Characterization of a Herpeslike (Hsiung-Kaplow) Virus from Guinea Pigs

Bhatt, P. N.; Percy, D. H.; Craft, Joseph L.; Jonas, A M

doi:10.1093/infdis/123.2.178

Cited by 26 publications

(16 citation statements)

References 18 publications

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“…A 'guineapigs herpes-like virus' (GPHLV) has been repeatedly isolated from kidney cells and other organ cultures derived from leukaemic and non-leukaemic animals (Hsiung & Kaplow, 1969;Booss & Hsiung, 1971;Bhatt, Percy, Craft & Jonas, 1971), and has been shown to be a DNA virus. However, no experimental infection could be produced with this virus: the intranuclear inclusion bodies were found only in degenerated tissue culture cells.…”

Section: Discussionmentioning

confidence: 99%

Lethal pneumonia in guineapigs associated with a virus

Naumann

Kunstýr

Langer³

et al. 1981

Lab Anim

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No bacteria were observed in an epizootic of lethal pneumonia in guineapigs. Necrotic bronchitis and bronchiolitis with basophilic intranuclear inclusion bodies in bronchial epithelial cells were characteristic. Although adenovirus infection of guineapigs has not previously been reported, histological findings paralleled those found in adenovirus infections of other animals including man. Virus particles found by electron-microscopical examination of the lung tissue closely resembled adenoviruses. The disease seemed to have a low contagiousness, a low morbidity (about 0·7%), but an acute course and a high mortality (100%).

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Section: Discussionmentioning

confidence: 99%

Lethal pneumonia in guineapigs associated with a virus

Naumann

Kunstýr

Langer³

et al. 1981

Lab Anim

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“…Originally, we were the first to report the isolation of a guinea pig herpes-like virus (GPHLV) from inbred strain 2 guinea pigs, although randomly bred Hartley guinea pigs occasionally harbor the virus . Subsequently, several other laboratories also isolated GPHLV; the virus was then named Hsiung-Kaplow herpesvirus (Bhatt et al, 1971). We surmised that since the virus was also commonly isolated from inbred guinea pigs, it must be transmitted transplacentally from mother to fetus from generation to generation.…”

Section: Clinic~virologymentioning

confidence: 99%

Mysteries and miracles

Hsiung¹

1995

Clinical and Diagnostic Virology

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“…Guinea pig herpes-like virus (GPHLV) was first isolated from spontaneously degen erating kidney cell cultures from leukemic strain-2 guinea pigs [1], Subsequently, it was isolated from nonleukemic strain-2 animals, Hartley, muta and other guinea pigs [2,3], Although GPHLV infection is clinically inapparent [2], GPHLV has been recovered from a variety of tissues obtained from both naturally and experimentally infected ani mals [4] and vertical transmission of the virus occurs commonly [5],…”

Section: Introductionmentioning

confidence: 99%