Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A

Ma, Zongwang; Wang, Nan; Hu, Jiangchun; Wang, Shujin

doi:10.1038/ja.2012.19

Cited by 97 publications

(65 citation statements)

References 28 publications

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“…From the foregoing account, it can be seen that a spectacular array of peptides/proteins and small molecules with inhibitory activity against phytopathogenic fungi such as Aspergillus niger, Alternaria longipes, Aspergillus fumigatus, Fusarium culmorum, Fusarium nivale, Piricularia oryzae, Saccharomyces cerevisiae , and Verticillium albo-atrum and also fungi like Candida albicans, Candida krusei, Candida guilliermondi and Candida parapsilosis, Cryptococcus neoformans and the dermatophytes Trichophyton rubrum, Trichophyton tonsurans, Trichophyton mentagrophytes, Microsporum canis , and Microsporum gypseum pathogenic to humans are produced by bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates. Like plant antifungal proteins (Li et al 2011a; Ma et al 2009; Wong et al 2011c, 2012; Ye and Ng 2009; Ye et al 2011), some of the antifungal proteins produced by marine organisms display antiproliferative activity toward tumor cells (Boonlarppradab and Faulker 2007; Gao et al 2012; Ma et al 2012). Similarly, the mechanism of antifungal action involves permeabilization of the fungal membrane (Sionov et al 2005; Wong et al 2012).…”

Section: Discussionmentioning

confidence: 99%

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Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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Marine organisms including bacteria, fungi, algae, sponges, echinoderms, mollusks, and cephalochordates produce a variety of products with antifungal activity including bacterial chitinases, lipopeptides, and lactones; fungal (−)-sclerotiorin and peptaibols, purpurides B and C, berkedrimane B and purpuride; algal gambieric acids A and B, phlorotannins; 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol, spongistatin 1, eurysterols A and B, nortetillapyrone, bromotyrosine alkaloids, bis-indole alkaloid, ageloxime B and (−)-ageloxime D, haliscosamine, hamigeran G, hippolachnin A from sponges; echinoderm triterpene glycosides and alkene sulfates; molluscan kahalalide F and a 1485-Da peptide with a sequence SRSELIVHQR; and cepalochordate chitotriosidase and a 5026.9-Da antifungal peptide. The antiviral compounds from marine organisms include bacterial polysaccharide and furan-2-yl acetate; fungal macrolide, purpurester A, purpurquinone B, isoindolone derivatives, alterporriol Q, tetrahydroaltersolanol C and asperterrestide A, algal diterpenes, xylogalactofucan, alginic acid, glycolipid sulfoquinovosyldiacylglycerol, sulfated polysaccharide p-KG03, meroditerpenoids, methyl ester derivative of vatomaric acid, lectins, polysaccharides, tannins, cnidarian zoanthoxanthin alkaloids, norditerpenoid and capilloquinol; crustacean antilipopolysaccharide factors, molluscan hemocyanin; echinoderm triterpenoid glycosides; tunicate didemnin B, tamandarins A and B and; tilapia hepcidin 1–5 (TH 1–5), seabream SauMx1, SauMx2, and SauMx3, and orange-spotted grouper β-defensin. Although the mechanisms of antifungal and antiviral activities of only some of the afore-mentioned compounds have been elucidated, the possibility to use those known to have distinctly different mechanisms, good bioavailability, and minimal toxicity in combination therapy remains to be investigated. It is also worthwhile to test the marine antimicrobials for possible synergism with existing drugs. The prospects of employing them in clinical practice are promising in view of the wealth of these compounds from marine organisms. The compounds may also be used in agriculture and the food industry.

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Section: Discussionmentioning

confidence: 99%

“…Mojavensin A was characterized by the possession of a peptide backbone of L-Asn(1), d -Tyr(2), D-Asn(3), l -Gln(4), l -Pro(5), d -Asn(6), l -Asn(7), and an anteiso-type of the saturated β-fatty acid side chain. The three lipopeptides inhibited a variety of phytopathogenic fungi (Ma et al 2012). …”

Section: Antifungal Productsmentioning

confidence: 99%

Antifungal and antiviral products of marine organisms

Cheung

Wong

Pan

et al. 2014

Appl Microbiol Biotechnol

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“…Three lipopeptides ( 8 – 10 ) (Figure 4), iso-C16 fengycin B ( 8 ), anteiso-C17 fengycin B ( 9 ) and a new iturinic lipopeptide, mojavensin A ( 10 ), were obtained by bioactivity-guided fractionation from the fermentation broth of B. mojavensis B0621A, which was isolated from the mantle of a pearl oyster P. martensii collected from Weizhou Island in the South China Sea [43]. These lipopeptides displayed dose-dependent antifungal activity against a broad spectra of phytopathogens as well as being weakly antagonistic to S. aureus .…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Mondol

Shin

Islam³

2013

Marine Drugs

206

132

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Marine Bacillus species produce versatile secondary metabolites including lipopeptides, polypeptides, macrolactones, fatty acids, polyketides, and isocoumarins. These structurally diverse compounds exhibit a wide range of biological activities, such as antimicrobial, anticancer, and antialgal activities. Some marine Bacillus strains can detoxify heavy metals through reduction processes and have the ability to produce carotenoids. The present article reviews the chemistry and biological activities of secondary metabolites from marine isolates. Side by side, the potential for application of these novel natural products from marine Bacillus strains as drugs, pesticides, carotenoids, and tools for the bioremediation of heavy metal toxicity are also discussed.

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“…Mojavensin A, iso-C16 fengycin B, and anteiso-C17 fengycin B are three lipopeptides isolated from the marine bacteria Bacillus mojavensis B0621A through extraction by bioassay-guided fractionation and fermentation. Three peptides were found to show broad spectrum antifungal activity and cytotoxic activity against human leukemia cell lines [103]. Anti-inflammatory peptides containing γ-amino-acid and thalassospiramides A, D and G were obtained from the culture of bacterial Thalassospira strain , CNJ328.…”

Section: Classification Of Marine Resourcesmentioning

confidence: 99%

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

2017

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Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market.

show abstract

Isolation and characterization of a new iturinic lipopeptide, mojavensin A produced by a marine-derived bacterium Bacillus mojavensis B0621A

Cited by 97 publications

References 28 publications

Antifungal and antiviral products of marine organisms

Antifungal and antiviral products of marine organisms

Diversity of Secondary Metabolites from Marine Bacillus Species: Chemistry and Biological Activity

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

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