Isolation and characterization of a new hispolone derivative from antioxidant extracts of Pistacia atlantica

Abstract

The quantification of the total phenolic compounds of Pistacia atlantica showed that the different parts of the tree are rich in natural phenolic compounds. The antioxidant tests proved that the phenolic extracts have a strong antioxidant activity. The positive correlation between the Trolox equivalent antioxidant capacity (TEAC) and the amount of phenolic compounds confirms their contribution to the antioxidant activity. Among the various phenolic compounds isolated and characterized by spectroscopic methods, a new natural antioxidant 1 (methyl 5-(3,4-dihydroxyphenyl)-3-hydroxypenta-2,4-dienoate) derived from hispolone 2 has been isolated from the mushroom Inonotus hispidus growing on Pistacia atlantica. Hispolone 2 (6-(3,4-dihydroxyphenyl)-4-hydroxyhexa-3,5-dien-2-one) and hispidin 3 (6-(2-(3,4-dihydroxyphenyl)vinyl)-4-hydroxy-2H-pyran-2-one) have been also identified using spectroscopic methods, including 2D-NMR and EI-MS.

In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine

“…Antioxidative properties were strongly attributed to Pistacia atlantica (Benhammou et al, 2008) mainly because of its richness with natural phenolic compounds (Yousfi et al, 2009). The substantially significant inhibitory effects of Pistacia atlantica aqueous extracts on enzymatic starch digestion are absolutely in line with and complementary to previously reported ␣-amylase inhibition in Hamdan and Afifi (2004).…”

FivePistaciaspecies (P. vera,P. atlantica,P. terebinthus,P. khinjuk, andP. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology

“…Gallic acid ( 36 ), catechin ( 37 ), epicatechin ( 38 ), and gallic acid methyl ester were identified in P. vera seed and skin, leaves of P. lentiscus and leaves and galls of P. atlantica [44–46]. Bhouri et al [47] demonstrated that digallic acid ( 39 ) from fruits of P. lentiscus has anti-mutagenic properties.…”

Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies

“…hispidin, bis-noryangonin and hypholomin B [13,14]. This fungus is used in folk medicine for treating gastric ulcer [15] and it is known by its antiviral activity [16].…”