Isolation and Characterization of a Novel Hydrophobin, Sa-HFB1, with Antifungal Activity from an Alkaliphilic Fungus, Sodiomyces alkalinus

Куварина, А. Е.; Рогожин, Е. А.; Sykonnikov, Maxim A.; Тимофеева, А. В.; Serebryakova, Marina V.; Федорова, Н. В.; Kokaeva, L.Y.; Ефименко, Т. А.; Георгиева, М. Л.; Садыкова, В. С.

doi:10.3390/jof8070659

Cited by 7 publications

(3 citation statements)

References 60 publications

(96 reference statements)

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“…Penicillium species of the surface waters of an acid mine produce two activators of signal transduction enzyme inhibition, including caspase-1 (Casp-1) and matrix metalloproteinase-3 (MMP-3) inhibitors [ 126 ]. Specific Casp-1 inhibitors may serve as new drug with highly potent cytotoxic activities [ 127 , 128 , 129 , 130 ]. The specific MMP inhibitors represented a novel therapeutic path to treat cancers by obstructing the activity of MMPs abused by tumour cells.…”

Section: Acidophilic and Alkaliphilic Fungimentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.

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Section: Acidophilic and Alkaliphilic Fungimentioning

confidence: 99%

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Kiss

Akbari

Marchev

et al. 2023

Life

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“…Some of these strains showed antimicrobial activity against the opportunistic pathogens Aspergillus niger INA 00760, Bacillus subtilis ATCC 6633, and Candida albicans ATCC 2091. In one of these strains, S. alkalinus 8KS17-10, a class II hydrophobin with antifungal activity against non- and clinical pathogenic isolates was purified and characterized [ 156 ]. We submitted the S. alkalinus genome (BioSample: SAMN02745840) to Antismash [ 157 ] to predict biosynthetic gene clusters and assess their potential as a producer of bioactives.…”

Section: Biotechnological Impact Of Alkaliphilic and Alkali-tolerant ...mentioning

confidence: 99%

Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological Aspects

Fernández-López

Batista-García

Aréchiga-Carvajal

2023

JoF

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Biotechnologist interest in extremophile microorganisms has increased in recent years. Alkaliphilic and alkali-tolerant fungi that resist alkaline pH are among these. Alkaline environments, both terrestrial and aquatic, can be created by nature or by human activities. Aspergillus nidulans and Saccharomyces cerevisiae are the two eukaryotic organisms whose pH-dependent gene regulation has received the most study. In both biological models, the PacC transcription factor activates the Pal/Rim pathway through two successive proteolytic mechanisms. PacC is a repressor of acid-expressed genes and an activator of alkaline-expressed genes when it is in an active state. It appears, however, that these are not the only mechanisms associated with pH adaptations in alkali-tolerant fungi. These fungi produce enzymes that are resistant to harsh conditions, i.e., alkaline pH, and can be used in technological processes, such as in the textile, paper, detergent, food, pharmaceutical, and leather tanning industries, as well as in bioremediation of pollutants. Consequently, it is essential to understand how these fungi maintain intracellular homeostasis and the signaling pathways that activate the physiological mechanisms of alkali resistance in fungi.

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“…with great biotechnological potential. New antimicrobial peptides named emericellipsins A-E and hydrophobins with antibacterial and antifungal activities were recently discovered to be produced by the alkaliphilic fungi Emericellopsis alkalina and Sodiomyces alkalinus [24,25]. These findings demonstrate the significance of conducting antimicrobial activity studies on the fungi present in these extreme environments.…”

Section: Introductionmentioning

confidence: 96%

Haloalkalitolerant Fungi from Sediments of the Big Tambukan Saline Lake (Northern Caucasus): Diversity and Antimicrobial Potential

Georgieva,

Bilanenko,

Ponizovskaya

et al. 2023

Microorganisms

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We have performed a characterization of cultivated haloalkalitolerant fungi from the sediments of Big Tambukan Lake in order to assess their biodiversity and antimicrobial activity. This saline, slightly alkaline lake is known as a source of therapeutic sulfide mud used in sanatoria of the Caucasian Mineral Waters, Russia. Though data on bacteria and algae observed in this lake are available in the literature, data on fungi adapted to the conditions of the lake are lacking. The diversity of haloalkalitolerant fungi was low and represented by ascomycetes of the genera Acremonium, Alternaria, Aspergillus, Chordomyces, Emericellopsis, Fusarium, Gibellulopsis, Myriodontium, Penicillium, and Pseudeurotium. Most of the fungi were characterized by moderate alkaline resistance, and they tolerated NaCl concentrations up to 10% w/v. The analysis of the antimicrobial activity of fungi showed that 87.5% of all strains were active against Bacillus subtilis, and 39.6% were also determined to be effective against Escherichia coli. The majority of the strains were also active against Aspergillus niger and Candida albicans, about 66.7% and 62.5%, respectively. These studies indicate, for the first time, the presence of polyextremotolerant fungi in the sediments of Big Tambukan Lake, which probably reflects their involvement in the formation of therapeutic muds.

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Isolation and Characterization of a Novel Hydrophobin, Sa-HFB1, with Antifungal Activity from an Alkaliphilic Fungus, Sodiomyces alkalinus

Cited by 7 publications

References 60 publications

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

The Cytotoxic Properties of Extreme Fungi’s Bioactive Components—An Updated Metabolic and Omics Overview

Alkaliphilic/Alkali-Tolerant Fungi: Molecular, Biochemical, and Biotechnological Aspects

Haloalkalitolerant Fungi from Sediments of the Big Tambukan Saline Lake (Northern Caucasus): Diversity and Antimicrobial Potential

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