Isolation and Characteristics of a 
            <i>Halomonas</i> sp. Accumulating Ectoine from Qinghai Lake

Liu, Jian; Li, Dandan; Yang, Fang; Rui, Haochen; Shen, Guoping; Liu, De Li; Zhu, Derui

doi:10.3724/sp.j.1145.2012.01049

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magmatic rocks in the Daye ore district are dominated by six plutons which are, from north to south, the Echeng, Tieshan, Jinshandian, Lingxiang, Yangxin, and Yinzu (Figure 1b). In addition, there are nearly 150 small quartz diorite, granodiorite and granite porphyry stocks occurring in or around the major plutons, such as the Tongshankou and Tonglushan (Liu et al, 2009). These major plutons and stocks formed between ca.…”

Section: The Daye Ore Districtmentioning

confidence: 99%

Chemical changes during endoskarn and porphyry‐style alteration and Cu—Fe exoskarn mineralization in the Tonglushan system, eastern China

Zhang,

Williamson,

Ullmann

et al. 2023

Resource Geology

View full text Add to dashboard Cite

Element mobility and chemical mass transfer are evaluated in the formation of Cu—Fe exoskarn deposits and endoskarn and minor porphyry‐style alteration in the Tonglushan quartz monzodiorite (QMD) system, eastern China. Endoskarn formation involved the migration of Ca into the QMD from the exoskarnification of carbonates (now marble) xenoliths and wall rocks, addition of Fe and Mn by magmatic‐hydrothermal fluids emanating from the interior of the QMD, and removal of alkali elements due to the replacement of feldspars and mica by prograde skarn minerals. Zirconium, Hf, U, and rare earth elements (REE) were added by hydrothermal fluids which were able to carry these often poorly mobile high field strength elements (HFSE) due to elevated F activity. Additions of Al were likely from Na‐rich fluids that also caused sodic alteration. Several factors favored mineralization within the exoskarns rather than endoskarns and QMD. The endoskarns were relatively oxidizing, as evidenced by a significant addition of Fe3+, which caused Cu to remain in magmatic‐hydrothermal fluids until they entered and precipitated sulphides in the more reducing environment of the exoskarns. Fluid migration from the QMD through the endoskarns and into the exoskarns was favored due to decarbonation of wall rock carbonates and related upwards migration of CO2 to produce a self‐sustaining chimney effect, which drew further fluids towards the carbonates to form, alter and mineralize the exoskarns. The higher porosity and permeability of the endoskarns compared with the QMD further promoted the lateral flow of Cu‐bearing fluids towards the exoskarns and limited porphyry‐style alteration and mineralization within the QMD. This proposed mechanism is only likely to be relevant for porphyry‐type systems developed predominantly within carbonate host rocks. Its significance for exploration models is that relatively poorly mineralized porphyry stocks in this setting may be associated with more substantive exoskarn deposits on their margins.

show abstract

Section: The Daye Ore Districtmentioning

confidence: 99%

Chemical changes during endoskarn and porphyry‐style alteration and Cu—Fe exoskarn mineralization in the Tonglushan system, eastern China

Zhang,

Williamson,

Ullmann

et al. 2023

Resource Geology

View full text Add to dashboard Cite

show abstract

“…MYH9 showed the highest competitive SILAC ratio and was previously reported to bind with dNTPs via a deoxyribose moiety and to play an essential role in DNA synthesis [18] . Overexpression of MYH9 affects clinicopathological parameters and prognosis of epithelial ovarian cancer [19] . Functional validation experiments were carried out with this protein hit.…”

Section: Figurementioning

confidence: 99%

“…[18] Overexpression of MYH9 affects clinicopathological parameters and prognosis of epithelial ovarian cancer. [19] Functional validation experiments were carried out with this protein hit. Knockdown of the MYH9 by siRNA transfection in A431 cells, the migration phenotype of A431was found to be hindered in the knockdown group.…”

mentioning

confidence: 99%

Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors

Peng

Guo

et al. 2022

ChemBioChem

View full text Add to dashboard Cite

Competitive proteome profiling is a powerful approach for the identification of targets of small molecules. This approach usually employs an inhibitor‐derived probe or a cysteine‐reactive probe such as an IA‐alkyne in a comparison between inhibitor‐treated and untreated samples, thus enabling distinction between genuine targets and nonspecific labeling. We have developed an active probe derived from an EGFR inhibitor, afatinib, and a cysteine reactive probe, an alkyne‐containing α,β‐unsaturated amide, to compare their characterization of cellular targets. In both approaches, myosin heavy chain 9 (MYH9) was identified as an off‐target. Subsequent functional validation experiments suggested that MYH9 might be involved in the function of afatinib.

show abstract

Isolation and Characteristics of a Halomonas sp. Accumulating Ectoine from Qinghai Lake

Cited by 2 publications

References 0 publications

Chemical changes during endoskarn and porphyry‐style alteration and Cu—Fe exoskarn mineralization in the Tonglushan system, eastern China

Chemical changes during endoskarn and porphyry‐style alteration and Cu—Fe exoskarn mineralization in the Tonglushan system, eastern China

Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors

Contact Info

Product

Resources

About