Isolation and characterisation of sesquiterpene lactones from Schkuhria pinnata and their antibacterial and anti-inflammatory activities

Kudumela, Refilwe Given; Mazimba, Ofentse; Masoko, Peter

doi:10.1016/j.sajb.2019.04.002

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…The NMR spectrum also showed the presence of 1, 2-disubstituted cis-olefin protons at 7.3 (1H, d) and 7.4 (1H, d). The 13 C NMR spectral data showed Based on spectral data and comparison with published data in previous literature, compound 3 was confirmed as umbelliferone [21,28]. Numerous studies have reported the cytotoxic activity of isolated compounds against different human cancer cell lines, viz., stigmasta-5, 22-dien-3-ol, octadecenamide, and umbelliferone through various mechanisms and pathways.…”

Section: Discussionmentioning

confidence: 62%

Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata

Wagh

Butle

Raut³

2021

Futur J Pharm Sci

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Background Spathodea campanulata P. Beauv. known as the African tulip tree has potential medicinal properties that have been shown traditionally for the treatment of various ailments. The aim of the present study was isolation, identification, and evaluation of the cytotoxic activity of phytochemicals from the chloroform extract of S. campanulata. Result Three compounds were isolated by using column chromatography and preparative TLC from chloroform extract of leaves of S. campanulata. The structures of the isolated compounds were elucidated by using spectroscopic methods, including, FTIR, ESI-TOF MS, 1H NMR, and 13C NMR spectroscopy. In vitro cytotoxic activity of compounds was evaluated by using SRB assay against human leukemia cancer cell lines (HL-60). Results were expressed in IC50 values. Stigmasta-5,22-dien-3-ol, octadecenamide, and umbelliferone were isolated and identified from chloroform extract. The isolated compounds showed cytotoxicity with decreasing cell viability in a dose-dependent manner, but it was found low as compared to positive control, i.e., Adriamycin against HL-60 cell lines. Conclusion The results indicate that isolated compounds, i.e., stigmasta-5,22-dien-3-ol (44.12μg/ml), octadecenamide (35.65μg/ml), and umbelliferone (80.60μg/ml) showed antiproliferative activity, but it was low compared to positive control Adriamycin (10.09 μg/ml). Also, according to our knowledge, this study is the first report on the isolation and identification of octadecenamide and umbelliferone from the leaves of S. campanulata. Graphical abstract

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Section: Discussionmentioning

confidence: 62%

Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata

Wagh

Butle

Raut³

2021

Futur J Pharm Sci

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“…This sesquiterpene lactone was also active when it was loaded onto polylactic acid nanoparticles with a free drug equivalent IC50 value of 3.32 µ M [ 25 ]. Eucannabinolide has also exhibited cytotoxic activity against tumour cell lines [ 26 ] and anti-inflammatory activity [ 27 ]. Compound 4 has also shown drug-like pharmacokinetic and toxicity properties ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Elso

Clavin

Hernández

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes and Leishmania infantum promastigotes. The extract of U. hecatantha showed activity against both parasites with IC50 values of 7 µg/mL and 31 µg/mL, respectively. Fractionation of the dichloromethane extract led to the isolation of euparin, jaceidin, santhemoidin C, and eucannabinolide. The sesquiterpene lactones eucannabinolide and santhemoidin C were active on T. cruzi with IC50 values of 10 ± 2 µM (4.2 µg/mL) and 18 ± 3 µM (7.6 µg/mL), respectively. Euparin and santhemoidin C were the most active on L. infantum with IC50 values of 18 ± 4 µM (3.9 µg/mL) and 19 ± 4 µM (8.0 µg/mL), respectively. Eucannabinolide has also shown drug-like pharmacokinetic and toxicity properties.

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“…A micro broth dilution method was used to test the antibacterial activity of compounds 33 and 34 . The results showed that compounds 33 and 34 both had antibacterial activity against Escherichia coli ( E. coli ), Pseudomonas aeruginosa ( P. aeruginosa ), Enterobacter faecalis ( E. faecalis ) , and S. aureus, and the MIC values were 125, 46.88, 125, and 62.5 µg/mL [ 26 ].…”

Section: Sesquiterpenoids Typesmentioning

confidence: 99%

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Yang

Zhou

et al. 2022

Biomolecules

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Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.

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Isolation and characterisation of sesquiterpene lactones from Schkuhria pinnata and their antibacterial and anti-inflammatory activities

Cited by 13 publications

References 28 publications

Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata

Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata

Antiprotozoal Compounds from Urolepis hecatantha (Asteraceae)

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

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