Isolation and biological activity of frankiamide

Abstract

An antibiotic produced by the symbiotic actinomycete Frankia strain AiPs1 was isolated from culture broth using optimized thin-layer chromatography and high-performance liquid chromatography (HPLC) methods. The novel compound that was isolated, dubbed frankiamide, displayed antimicrobial activity against all 14 Gram-positive bacterial strains and six pathogenic fungal strains tested. The pathogenic actinomycete Clavibacter michiganensis and the oomycete Phytophthora were especially susceptible. In addition to displaying antimicrobial activity, frankiamide also strongly inhibited 45Ca(2+) fluxes in clonal rat pituitary GH4C1 tumor cells and was comparable to a frequently used calcium antagonist, verapamil hydrochloride. The results of HPLC analysis, supported by both nuclear magnetic resonance and mass spectroscopy studies, showed that frankiamide has a high affinity for Na(+) ions.

Spectroscopic, antimicrobial and computational study of novel benzoxazole derivative

“…Heterocyclic compounds have attracted attention due to their diverse biological and pharmacological properties. Benzoheterocycles such as benzoxazolesare important fragments in medicinal chemistry because of their wide range of biological activities such as antibacterial, antifungal, anti-tubercular, anti-tumoral and antiviral activities [1][2][3][4][5][6][7][8]. In the present study, 2-(pmethylphenyl)-5-(2-(4-ethylpiperazine-1-yl)acetamido) benzoxazole (PMPEPAB) was synthesized using a three step procedure and the synthetic pathways for preparation of the target compound with the hope of discovering new effective antimicrobial agent.…”

Bazı benzoksazol türevlerinin moleküler modelleme çalışmaları

“…Bu nedenle son yıllarda bu türevler üzerindeki çalışmalar arttırılmıştır. Yapılan araştırmalar benzoksazol ve analoglarının mikrobiyolojik aktiviteleri yönünden kayda değer sonuçlar veren bileşikler olduğunu göstermektedir [2][3][4][5][6][7][8].…”

Novel Benzoxazoles: Synthesis and Antibacterial, Antifungal, and Antitubercular Activity against Antibiotic-Resistant and -Sensitive Microbes

“…Benzoxazoles are structural isosters of natural nucleotides which interact easily with biopolymers, and they constitute an important class of heterocyclic compounds with antitubercular, antimicrobial, and antibiotic activities (Prudhomme et al, 1986;Haansuu et al, 2001;Kochi et al, 2002;Temiz-Arpaci et al, 2002a, b;Sarma et al, 2003;Vinsova et al, 2005Vinsova et al, , 2006. The benzoxazole derivative calcimycin is a carboxylic polyether antibiotic from a strain of Streptomyces chartreusis (NRRL 3882).…”