Isolation and antibiotic susceptibility of bacteria from foot infections in the patients with diabetes mellitus type I and type II in the district of Kancheepuram, Tamil Nadu, India

Kannan, Iyanar; Premavathy, R.K.; Cecilia, Sambandam; Jayalakshmi, M; Priyadarsini, S Sruthi; S, Shantha

doi:10.5455/2320-6012.ijrms20140515

Cited by 4 publications

(5 citation statements)

References 9 publications

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“…The demographic profile of the Diabetic foot ulcer patients showed that males(84%) were commonly more affected than females (16%). The male:female ratio was 3:1 which is in consistence with the findings of other studies (Mathangi and Prabhakaran 2013; Iyanar et al, 2014;Yerat and Rangasamy, 2015;). This may be due to higher level of outdoor activities among males compared to females (Zubair et al, 2010).…”

Section: Results and Discussion Demographic Features Of The Patientssupporting

confidence: 91%

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Drug Susceptibility Pattern of Bacterial Pathogens associated with Diabetic Foot Ulcers of Patients in Kano North –Western Nigeria

Sani¹,

Musa²,

Muhammad³

et al. 2019

UJMR

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Diabetic foot ulcer has become the major cause of amputation in people with diabetes. Infected foot ulcers are a cause of morbidity and hospitalization in diabetic patients. The aim of the current study was to isolate and ascertain antimicrobial susceptibility pattern of bacterial pathogens associated with diabetic foot infection in Kano NorthWest , Nigeria. Samples were collected from 100 patients with diabetic foot ulcers using sterile cotton swab and transported to the laboratory for analysis. The male: female ratio was 3:1. Mono bacterial nature of diabetic foot infection was observed in 68% of the samples while mixed bacterial infection was observed in 21% of the samples. The study showed that Gram negative bacteria (84%) was the most frequently isolated pathogen and E. coli was found to be predominant (27%) followed by Klebsiella species (21%) and Proteus species (19%).Among the Gram positive bacteria, S. aureus (16%) was the predominant pathogen. The result also showed that most of the isolated bacteria were sensitive to Ciprofloxacin, Ofloxacin, Nitrofurantoin and Gentamicin. However, they showed resistance to Augumentin, Cefixime, Ceptaxidime and Cefuroxime. Further studies needs to be carried out to explore anaerobic pathogens related to diabetic wound and to ascertain the causes of resistance to antibiotics for proper management of diabetic foot ulcer in the study area.

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Section: Results and Discussion Demographic Features Of The Patientssupporting

confidence: 91%

“…Many studies have reported on the bacteriology of diabetic foot infection. Iyanar et al, (2014)stated that the bacteriology of Diabetic foot infection (DFI) is highly complicated. It involves both aerobes and anaerobes and mixed infection.…”

Section: Introductionmentioning

confidence: 99%

Drug Susceptibility Pattern of Bacterial Pathogens associated with Diabetic Foot Ulcers of Patients in Kano North –Western Nigeria

Sani¹,

Musa²,

Muhammad³

et al. 2019

UJMR

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“…These findings correlated well with those of studies carried out in India which showed that gram-negative bacilli as the most common organism and pseudomonas being the predominant pathogen. [19][20][21] However, few studies reported gram positive as the most common organism and Staphylococcus aureus as the most common isolate. [22][23][24] Therefore, there seems to be a changing trend in the organisms causing diabetic foot infections with gram-negative bacteria replacing gram-positive bacteria as commonest agents.…”

Section: Discussionmentioning

confidence: 99%

Study on bacteriological profile and antibiotic susceptibility pattern in patients with diabetic foot ulcers in a tertiary care teaching hospital

Shareef¹,

Sunny²,

Bhagavan

2018

Journal of Social Health and Diabetes

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Introduction:Diabetic foot ulcer and infections are one of the major complications in diabetic patients leading to frequent hospitalization and increased mortality. Knowledge about the microbes that cause infections will be helpful for providing appropriate antimicrobial therapy. Aim:To evaluate the bacteriological profile of patients with diabetic foot ulcers and their antibiotic susceptibility pattern. Methodology:A cross-sectional study was carried out for a period of eight months in the Department of surgery in patients with diabetic foot ulcer at a tertiary care teaching hospital. Patient data relevant to the study were collected using a standard data collection form designed as per the need of the study. Details of the organisms isolated and susceptibility pattern were collected from microbiology department. Results:A total of 122 pathogens were identified from 71 patients with male (63.38%) predominance over females (36.61%). Out of the 71 patients, 38 (53.52%) patients had monomicrobial infections and 33 (46.47%) patients had polymicrobial infections. Of the total 122 organisms, 79(64.75%) organisms were found to be gram negative organisms and 43(35.24%) were gram positive. Pseudomonas aeruginosa found in 22 (18.03%) patients was the predominant pathogen isolated followed by Klebsiella pneumonia found in 18 (14.75%) patients. The gram-positive organisms isolated showed maximum susceptibility towards antibiotics Teicoplanin and Linezolid while the gram-negative organisms showed susceptibility to Imipenem, Meropenem, and Piperacillin/Tazobactum combination. Conclusion:The study showed a preponderance of gram-negative bacilli among the isolates from the diabetic foot ulcers. It is recommended that antimicrobial sensitivity testing is necessary for initiating appropriate antibiotic regimen which will help to reduce the drug resistance and minimize the healthcare costs.

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“…The discrepancy may possibly due to the difference in the causative organisms, which have occurred over time, geographical variations, the type of the severity of the infection, that were reported in the studies. 34 The frequently diabetic foot ulcer hass mixed bacterial infections and the proper management of those infection are necessary using appropriate antibiotic selection, culture based antimicrobial susceptibility testing etc 34 treatment of the ulcers may avoid up to 85% of amputation 35 . Deny the reality, that a variety of medicines are available on the market to treat microbial infections, overcoming drug resistance in bacteria is a difficult challenge 36 .…”

Section: Discussionmentioning

confidence: 99%

MDR Isolates Virulence of DNase activity Identified Staphylococcus and Pseudomonas Species from Diabetic Foot Ulcer

Venkatesan¹,

Raja²

2022

Int J Life Sci Pharm Res

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Diabetes mellitus is the leading cause of death and morbidity from long-term consequences. Antibiotic resistance is the most common treatment for diabetic foot ulcers. Chronic wounds are caused by antibiotic misuse, mistreatment of medications, and a reduction in the effectiveness of effective antibiotics in the wound or infection environment. Chemical suppression of bacterial intercellular communication, particularly quorum sensing, is of particular relevance in this regard because it regulates pathogenicity in many therapeutically relevant infections where resistance to antibiotics is a challenge. Resistance genes are also acquired through the interchange of bacterial plasmids and chromosomal. Our aim and objective is to microbiological culture study for the clinical pus samples of foot diabetic patients. Our study comprised 131 samples from diabetic foot ulcer patients, with male patients providing for 59% and female patients accounting for 41%. In 131 sample progressing reports, 81 isolates were discovered, ranging in age from 40 to 80 years. The most commonly infected age groups are 51 to 60, with the majority of infection cases categorized as grade III. A sample was taken. The sample grew 97 percent of the time and grew just 3% of the time, with mono microbial growth 48 percent of the time and poly microbial growth 49 percent of the time. MDR Gram positive staphylococci 14 isolates and gram negative pseudomonas 11 isolates showed resistance to 25 culture DNase enzyme activity. In staphylococci 9 isolates and pseudomonas 6 isolates, the DNase enzyme activity in DNase agar media light zone formed. In conclusion diabetic foot ulcers are one of the most prevalent, expensive, and serious consequences of diabetes, and they are considered a major public health issue. Early diagnosis and successful therapy require accurate identification of the causative microorganisms.

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Isolation and antibiotic susceptibility of bacteria from foot infections in the patients with diabetes mellitus type I and type II in the district of Kancheepuram, Tamil Nadu, India

Cited by 4 publications

References 9 publications

Drug Susceptibility Pattern of Bacterial Pathogens associated with Diabetic Foot Ulcers of Patients in Kano North –Western Nigeria

Drug Susceptibility Pattern of Bacterial Pathogens associated with Diabetic Foot Ulcers of Patients in Kano North –Western Nigeria

Study on bacteriological profile and antibiotic susceptibility pattern in patients with diabetic foot ulcers in a tertiary care teaching hospital

MDR Isolates Virulence of DNase activity Identified Staphylococcus and Pseudomonas Species from Diabetic Foot Ulcer

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