Isolation and analysis of articular joints wear debris generated in vitro

Kowandy, C.; Mazouz, Hammoudi; Richard, Caroline

doi:10.1016/j.wear.2006.03.029

Cited by 22 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Articulating surfaces of medical implants, resulting from total joint replacement surgeries, generate a large number of particles as a result of wear process over time [5]. Damage from wear can directly affect the implanted device causing loss of tolerance, friction and therefore the expected longevity of the device is minimised [6]. wear particles also initiate an immune response inducing aseptic loosening, and osteolysis [6]- [8].…”

Section: Introductionmentioning

confidence: 99%

“…Damage from wear can directly affect the implanted device causing loss of tolerance, friction and therefore the expected longevity of the device is minimised [6]. wear particles also initiate an immune response inducing aseptic loosening, and osteolysis [6]- [8]. The cellular mechanism of the response to wear particles involves macrophages, monocytes, osteoblasts, and osteoclasts cells [9]- [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity

Preedy

Perni

Prokopovich

2017

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Bone cells are damaged by wear particles originating from total joint replacement implants. We investigated Mesenchymal stem cells (MSCs) nanomechanical properties when exposed to cobalt and titanium nanoparticles (resembling wear debris) of different sizes for up to 3days using AFM nanoindentation; along with flow-cytometry and MTT assay. The results demonstrated that cells exposed to increasing concentrations of nanoparticles had a lower value of elasticity and spring constant without significant effect on cell metabolic activity and viability but some morphological alteration (bleeping). Cobalt induced greater effects than titanium and this is consistent with the general knowledge of cyto-compatibility of the later. This work demonstrates for the first time that metal nanoparticles do not only influence MSCs enzymes activity but also cell structure; however, they do not result in full membrane damage. Furthermore, the mechanical changes are concentration and particles composition dependent but little influenced by the particle size.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity

Preedy

Perni

Prokopovich

2017

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

show abstract

“…During the last ten years, particular attention was paid to metal on metal (MoM) coupling for arthroprosthesis, because of lower volumetric wear compared to metal on polyethylene (MoP) coupling, as well as higher durability than ceramic on ceramic (CoC) coupling [5][6][7][8]. Mechanical and chemical degradation of joint devices (MoP or MoM) leads to polyethylene and metal debris formation, which means release of metal particulate and ions [9][10][11][12]. Polyethylene debris, produced in the size range of biological activation, are the principal cause of osteolysis [13] and implant failure for aseptic loosening.…”

Section: Introductionmentioning

confidence: 99%

Tribological behavior of a Ta-based coating on a Co–Cr–Mo alloy

Balagna

Faga

Spriano

2014

Surface and Coatings Technology

View full text Add to dashboard Cite

“…The generation of polyethylene wear debris from replacement bearing surfaces is considered to be a major problem for long-term outcome of total joint arthroplasty. [1][2][3][4][5] Cross-linking has been introduced to reduce the wear of ultra-high-molecular-weight polyethylene (UHMWPE). Cross-linking may provide significant advantages over conventional UHMWPE, regarding the mechanical and wear properties.…”

Section: Introductionmentioning

confidence: 99%

Quantification of the effect of cross-shear and applied nominal contact pressure on the wear of moderately cross-linked polyethylene

Abdelgaied

Brockett

Liu

et al. 2012

Proc Inst Mech Eng H

View full text Add to dashboard Cite

Polyethylene wear is a great concern in total joint replacement. It is now considered a major limiting factor to the long life of such prostheses. Cross-linking has been introduced to reduce the wear of ultra-high-molecular-weight polyethylene (UHMWPE). Computational models have been used extensively for wear prediction and optimization of artificial knee designs. However, in order to be independent and have general applicability and predictability, computational wear models should be based on inputs from independent experimentally determined wear parameters (wear factors or wear coefficients). The objective of this study was to investigate moderately cross-linked UHMWPE, using a multidirectional pin-on-plate wear test machine, under a wide range of applied nominal contact pressure (from 1 to 11 MPa) and under five different kinematic inputs, varying from a purely linear track to a maximum rotation of +/- 55 degrees. A computational model, based on a direct simulation of the multidirectional pin-on-plate wear tester, was developed to quantify the degree of cross-shear (CS) of the polyethylene pins articulating against the metallic plates. The moderately cross-linked UHMWPE showed wear factors less than half of that reported in the literature for, the conventional UHMWPE, under the same loading and kinematic inputs. In addition, under high applied nominal contact stress, the moderately crosslinked UHMWPE wear showed lower dependence on the degree of CS compared to that under low applied nominal contact stress. The calculated wear coefficients were found to be independent of the applied nominal contact stress, in contrast to the wear factors that were shown to be highly pressure dependent. This study provided independent wear data for inputs into computational models for moderately cross-linked polyethylene and supported the application of wear coefficient-based computational wear models.

show abstract

Isolation and analysis of articular joints wear debris generated in vitro

Cited by 22 publications

References 10 publications

Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity

Cobalt and titanium nanoparticles influence on mesenchymal stem cell elasticity and turgidity

Tribological behavior of a Ta-based coating on a Co–Cr–Mo alloy

Quantification of the effect of cross-shear and applied nominal contact pressure on the wear of moderately cross-linked polyethylene

Contact Info

Product

Resources

About