Isolated vaginal metastasis from stage I colon cancer: A case report

Kwon, Seog Woon; Yu, Chang Sik; Lee, Shin-Wha; Kim, Jihun; Song, In‐Ho; Lee, Jong Lyul; Kim, Chan Wook; Yoon, Yong Sik; Park, In Ja; Lim, Seok‐Byung; Kim, Jin Cheon

doi:10.12998/wjcc.v8.i3.527

Cited by 3 publications

(5 citation statements)

References 22 publications

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“…The final hypothesis suggests a hematogenous route, where metastatic cells travel from the primary tumor to the ovarian plexus and then through the vaginal veins. This last hypothesis appears to be more acceptable for differentiating vaginal metastases from colorectal cancer [ 1 , 2 ]. In the current case, this hypothesis also appears to be the most plausible, particularly considering that the tumor invaded the rectum extrinsically, while the mucosa remained free of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis is established through clinical signs and gynecological examination, with confirmation achieved through biopsy of the lesion. Radiological examination, specifically magnetic resonance imaging (MRI), can be helpful in detecting vaginal metastasis [ 1 ]. F-fluorodeoxyglucose positron emission tomography (FDG PET)/computed tomography (CT) is useful for the diagnosis of vaginal metastasis at an early stage and to detect distant metastasis [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was treated similarly to primary vaginal carcinomas, employing radiotherapy followed by surgical resection. Subsequently, the patient received adjuvant chemotherapy, either individually or in combination [ 1 , 2 ].…”

Section: Discussionmentioning

confidence: 99%

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An isolated vaginal metastasis from rectal cancer: a case report

Sakhri,

Zemni,

Ayadi

et al. 2024

J Med Case Reports

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Introduction Vaginal metastasis from colorectal cancer is a rare occurrence, typically associated with other metastatic lesions. Isolated metastasis is exceedingly uncommon, with only a few cases documented in the literature. Vaginal involvement in colorectal cancer primarily results from direct contiguous spread from the primary tumor. Case presentation We present the case of a 70-year-old African woman diagnosed with adenocarcinoma of the middle rectum. She underwent chemotherapy, radiotherapy, and subsequent anterior resection. After 2 months, an isolated metastasis of rectal cancer was identified in the lower third of the left vaginal wall, confirmed by biopsy. Colonoscopy ruled out colorectal recurrence. Thoraco-abdominal computed tomography scan showed no distant metastases. The patient underwent abdominoperineal resection, removing the lateral and posterior vaginal wall with free macroscopic margins and a definitive colostomy. The final histopathological analysis confirmed the diagnosis of moderately differentiated adenocarcinoma of the vagina, measuring 5 × 4.5 cm. The rectal wall was extrinsically invaded by the tumor down to the muscularis propria while respecting the rectal mucosa. Resection margins were negative. The patient was discharged 1 week postoperation with no complications. Adjuvant chemotherapy was indicated, and the patient is currently tolerating the treatment well. Conclusion Vaginal metastases from colorectal cancer are extremely rare. A vigilant gynecological examination is recommended during the follow-up of colorectal cancer patients. Diagnosis can be challenging, especially if the metastatic lesion is small and asymptomatic, even after standard radiological examination. Surgical resection followed by chemotherapy is a valid option for patients with early isolated metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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An isolated vaginal metastasis from rectal cancer: a case report

Sakhri,

Zemni,

Ayadi

et al. 2024

J Med Case Reports

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“…The majority of reported vaginal metastasis are derived from cervical (51%), endometrial (13.3%), ovarian cancer [36][37][38], kidney (1.3%) [39], colon [40], breast, pancreas [41] or bladder cancer. We would like to mention that some rare metastases were selected from articles that did not mention with certainty the type of ovarian tumor.…”

Section: Discussionmentioning

confidence: 99%

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature

et al. 2021

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Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described. The local or systemic relapse together with local and distant metastasis is considered as an independent predictor of poor survival in patients with OD. In light of the absence of mutations status, our patient successfully responded to therapy. Currently, the patient remains in clinical remission. A specific follow-up plan is ongoing knowing that ovarian dysgerminomas tend to recur most often in the first 2–3 years after treatment.

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“…Transvaginal wide excision was performed in 11 of 13 patients with the isolated vaginal metastases, and external beam RT (EBRT) was applied to the remaining 2 patients. Of the 11 patients who underwent the transvaginal wide excision, 3 received postoperative chemotherapy, 5 received postoperative RT, and the remaining 3 were followed without additional therapy [3].…”

Section: Vaginal Recurrence Of Colorectal Cancermentioning

confidence: 99%

Vaginal metastasis in solid tumours: our four cases and review of the literature

Korkmaz

Eryılmaz

Kerimoğlu

et al. 2021

J Egypt Natl Canc Inst

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Background Vaginal metastasis should be kept in mind when evaluating the staging tests of all cancers, especially endometrial cancer. Case presentation We present four patients with vaginal recurrence who recently applied to our clinic. Three cases were of endometrial cancer and one case of rectal cancer. All patients presented with vaginal bleeding. Conclusion Standard treatment for vaginal metastasis has not yet been established. Therapeutic options for vaginal metastasis—separately or in combination—are surgical resection, radiotherapy, and chemotherapy.

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Isolated vaginal metastasis from stage I colon cancer: A case report

Cited by 3 publications

References 22 publications

An isolated vaginal metastasis from rectal cancer: a case report

An isolated vaginal metastasis from rectal cancer: a case report

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature

Vaginal metastasis in solid tumours: our four cases and review of the literature

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