Isolated Transient Neonatal Clitoromegaly with Hyperandrogenism of Unknown Etiology

Dumont, Tania; Ahmet, Alexandra; Fleming, Nathalie

doi:10.1016/j.jpag.2009.01.066

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…Multiple reports have noted that these findings resolve over a period of months, without any specific intervention. Some patients have had elevated follicle stimulating hormone (FSH), luteinizing hormone (LH), androgens or the presence of ovarian cysts [1][2][3]. The present patient was an extremely preterm infant with initially normal appearance of the clitoris followed by clitoral enlargement associated with POHS.…”

Section: Introductionmentioning

confidence: 85%

New Onset Clitoromegaly in a Preterm Infant: Premature Ovarian Hyperstimulation Syndrome

Geliebter¹,

Derrick²,

Drzewiecki³

et al. 2021

Mathews Journal of Pediatrics

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Neonatal clitoromegaly can result from overproduction of androgens by the fetus, the mother, or the placenta. Premature infants can also appear to have clitoromegaly due to variations in external genitalia. The patient reported is an extremely preterm infant who was assigned female sex at birth with a normal physical exam other than premature features. At 35 weeks corrected gestational age (CGA), the patient developed significant clitoromegaly with elevated gonadotropins, androstenedione, and dehydroepiandrosterone sulfate (DHEA-S). Further workup yielded the diagnosis of Premature Ovarian Hyperstimulation Syndrome (POHS). Hormone levels declined over time and her clitoromegaly resolved without intervention. This case of POHS is the first to document elevated DHEA-S as part of the diagnosis. Elevated DHEA-S has not been previously reported in POHS and it is likely that it contributed to the clitoromegaly. Recognizing POHS is important as the associated clitoromegaly typically resolves.

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Section: Introductionmentioning

confidence: 85%

New Onset Clitoromegaly in a Preterm Infant: Premature Ovarian Hyperstimulation Syndrome

Geliebter¹,

Derrick²,

Drzewiecki³

et al. 2021

Mathews Journal of Pediatrics

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show abstract

“…The authors suggested that these changes were due to a relative immaturity in the adrenal gland of the preterm newborn. Dumont et al 8 described a female infant who was born at 25.5 weeks' gestation. Clitoromegaly was first documented at 3 months of age and resolved at 5 months of age.…”

Section: Discussionmentioning

confidence: 99%

Fetal Transient Clitoromegaly and Transient Hypertrophy of the Labia Minora in Early and Mid Pregnancy

Zimmer¹,

Blazer²,

Blumenfeld³

et al. 2012

Journal of Ultrasound in Medicine

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Objective The purpose of this study was to describe a series of cases of transient changes in the female fetal external genitalia. Methods In our practice area, most pregnant women usually undergo a detailed sonographic survey of all fetal organs, including the external genitalia in early and mid pregnancy. Results During the study period (1987–2010), 62,145 consecutive pregnant women were scanned. We detected 4 fetuses with an isolated finding of clitoromegaly at 15 to 16 weeks' gestation, which disappeared at 22 to 26 weeks. Maternal hormonal study results were normal. There was 1 case of clitoromegaly and a cloacal anomaly at 15 weeks' gestation, in which the clitoris retuned to a normal size at 22 weeks. In addition, there were 3 cases of hypertrophy of the labia minora in early pregnancy, which disappeared at 26 to 32 weeks. All fetuses in these series had a normal XX karyotype and normal external genitalia at birth. Conclusions Transient changes in the appearance of the fetal external genitalia may occur in chromosomally normal female fetuses.

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“…In addition, uncertainty related to the diagnosis and fear of stigmatization cause substantial psychological stress for parents [21][22][23]. Most of these infants undergo an extensive evaluation to rule out hormonal pathology [24,25].…”

Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

“…Several studies have reported transient clitoromegaly in premature infants, but the exact mechanisms are not well understood. High circulating androgen levels have been associated with transient clitoromegaly in infants born prematurely [4,24,26,27]. One of the proposed mechanisms for these transiently elevated androgen levels is the persistence of fetal adrenal zone activity until 42 weeks post-menstrual age (PMA) regardless of gestational age (GA) at birth [28,29].…”

Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

Clitoromegaly in Premature Infants: Is It Truly Pathologic?

Gupta

2021

AJPN

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BackgroundClitoromegaly, or abnormal enlargement of the clitoris, can be congenital or acquired and is usually associated with excess androgen exposure. Neonatal clitoromegaly can result from hormonal causes such as in-utero androgen exposure of fetal, maternal, or placental origin. Occasionally, non-hormonal conditions like certain syndromes (e.g. Beckwith-Wiedemann Syndrome, etc.), field defects, cysts or tumors of the clitoris may result in clitoromegaly [1]. The most common pathologic cause of neonatal clitoromegaly is congenital adrenal hyperplasia (CAH) with an incidence of about 1:10,000 to 1:20,000 [2][3][4]. However,

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Isolated Transient Neonatal Clitoromegaly with Hyperandrogenism of Unknown Etiology

Cited by 10 publications

References 20 publications

New Onset Clitoromegaly in a Preterm Infant: Premature Ovarian Hyperstimulation Syndrome

New Onset Clitoromegaly in a Preterm Infant: Premature Ovarian Hyperstimulation Syndrome

Fetal Transient Clitoromegaly and Transient Hypertrophy of the Labia Minora in Early and Mid Pregnancy

Clitoromegaly in Premature Infants: Is It Truly Pathologic?

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