Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection

Keegan, Brian R.; Barton, Staci C.; Sanchez, Xavier Moll; Berkeley, Alan S.; Krey, L.C.; Grifo, James A.

doi:10.1016/j.fertnstert.2007.01.057

Cited by 101 publications

(85 citation statements)

References 34 publications

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“…Several clinical studies have demonstrated a clear association between sperm head morphology and improvement in IVF success rate [4,26,27]. However, other works showed lack of correlation between these parameters [28,29]. The conventional methods for the evaluation of sperm morphology are highly variable causing difficulty in interpretation of results although several efforts have been made to overcome these problems.…”

Section: Discussionmentioning

confidence: 99%

CASA derived human sperm abnormalities: correlation with chromatin packing and DNA fragmentation

Sivanarayana

Krishna

Prakash³

et al. 2012

J Assist Reprod Genet

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Purpose The present study was undertaken to evaluate the effects of morphokinetic abnormalities of human spermatozoa on chromatin packing and DNA integrity and possible beneficial effects of sperm selection in ICSI. Methods Semen samples from 1002 patients were analysed for morphology and motility using CASA. Protamine status and DNA fragmentation were analysed by chromomycin A3 staining and sperm chromatin dispersion assay respectively. Results Sperms with elongated, thin, round, pyri, amorphous, micro and macro forms were significantly higher in teratozoospermic and oligoasthenoteratozoospermic groups. Significant difference in chromatin packing and DNA fragmentation index was observed in these abnormal groups compared with normal. Similarly significant correlation was also seen between abnormal motility parameters and DNA fragmentation index in asthenozoospermic group compared with normal. Conclusions Specific abnormal morphological forms have higher incidence of chromatin packing abnormalities and DNA fragmentation. Using these sperms in ICSI might have an impact on fertilization, embryo development and abortion rates. These can be selectively avoided during ICSI procedure to improve ART outcome.

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Section: Discussionmentioning

confidence: 99%

CASA derived human sperm abnormalities: correlation with chromatin packing and DNA fragmentation

Sivanarayana

Krishna

Prakash³

et al. 2012

J Assist Reprod Genet

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“…Oocyte retrieval via transvaginal ultrasound-guided needle aspiration of ovarian follicular fluid was performed 36 h later. Sperm was processed for insemination or intracellular sperm injection (ICSI) as previously described [22,23]. ICSI was performed for patients diagnosed with male factor infertility or a history of failed fertilization.…”

Section: Methodsmentioning

confidence: 99%

In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43

Lee

McCulloh

Hodes-Wertz

et al. 2015

J Assist Reprod Genet

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Purpose In Vitro Fertilization is an effective treatment for infertility; however, it has relatively low success in women of advanced maternal age (>37) who have a high risk of producing aneuploid embryos, resulting in implantation failure, a higher rate of miscarriage or birth of a child with chromosome abnormalities. The purpose of this study was to compare the implantation, miscarriage and live birth rates with and without preimplantation genetic screening (PGS) of embryos from patients aged 40 through 43 years. Methods This is a retrospective cohort study, comparing embryos screened for ploidy using trophectoderm biopsy and array comparative genomic hybridization to embryos that were not screened. We compared pregnancy outcomes for traditional fresh IVF cycles with day 5 embryo transfers, Frozen Embryo Transfer (FET) cycles without PGS and PGS-FET (FET of only euploid embryos) cycles of patients with maternal ages ranging from 40 to 43 years, undergoing oocyte retrievals during the period between 1/1/2011 and 12/ 31/2012. Results The implantation rate of euploid embryos transferred in FET cycles (50.9 %) was significantly greater than for unscreened embryos transferred in either fresh (23. Conclusions The present data provides evidence of the benefits of PGS with regard to improved implantation and live birth rate per embryo transferred.

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“…In contrast to the above a statistically significant difference in fertilization rate, total fertilization failure, pregnancy outcome, or live birth rates among patients with isolated teratozoospermia (morphologically normal sperms < 5% of total sperm count) and normal morphological semen profile in the first or second IVF cycle, and ICSI did not seem to improve the outcome in cases of isolated teratozoospermia [Keegan et al 2007]. However, the confounding factors such as duration of infertility, history of previous treatments, and comorbidities that may affect quality of oocytes or endometrium receptivity were not well-controlled.…”

Section: Discussionmentioning

confidence: 56%

“…On one hand, some institutes recommend ICSI for the treatment of isolated teratozoospermia [Plachot et al 2002;Tournaye et al 2002]. On the other hand, there are of series of studies indicating that fertilization rate and/ or pregnancy outcome are not improved by ICSI for these couples [Hall et al 1995;Hotaling et al 2011;Keegan et al 2007;Mansour et al 1995;Robinson et al1994].…”

Section: Introductionmentioning

confidence: 99%

ICSI improves fertilization in isolated teratozoospermic men: a study with strictly controlled external factors and WHO-5 standard

Zhu

Zhou

et al. 2012

Systems Biology in Reproductive Medicine

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The Reproductive Centre of the Women and Children Hospital of Jiangxi Province, Nanchang, P.R.China, 3 The Department of Social Medicine, The Medical School of Nanchang University, Nanchang, P.R.China A clear clinical management pathway (conventional in vitro fertilization, IVF or intracytoplasmic sperm injection, ICSI) for treating patients with teratozoospermia is lacking. Here we conducted a retrospective study of fertility indices in 2,178 IVF/ICSI cycles in order to reevaluate clinical management of couples with isolated teratozoospermia (< 4% morphologically normal sperms and normal sperm concentration and motility with the standard of WHO-5).We strictly controlled external factors that could affect oocyte quality or endometrial receptivity to minimize the impact of confounders. Fertilization, total fertilization failure, embryo quality, blastocyst formation rate, and pregnancy rate were studied. Retrospectively, in conventional IVF cycles a significantly lower fertilization rate and higher total fertilization failure rate were observed in couples with isolated teratozoospermia as compared to couples with a normal semen profile. Furthermore, when ICSI was used to treat these teratozoospermic couples, improvement in fertilization was noted. However, the embryo quality, blastocyst formation rate, and pregnancy of couples with isolated teratozoospermia were not enhanced by ICSI. Multiple variable analysis showed that many factors including percentage of morphologically normal sperm are statistically correlated with fertilization rate and total fertilization failure in conventional IVF cycles. In addition the insemination method was correlated with fertilization rate in cases with isolated teratozoospermia. Further studies are warranted to compare outcomes of conventional IVF and ICSI in cases of isolated teratozoospermia, where less than 5 oocytes are retrieved.

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Isolated teratozoospermia does not affect in vitro fertilization outcome and is not an indication for intracytoplasmic sperm injection

Cited by 101 publications

References 34 publications

CASA derived human sperm abnormalities: correlation with chromatin packing and DNA fragmentation

CASA derived human sperm abnormalities: correlation with chromatin packing and DNA fragmentation

In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43

ICSI improves fertilization in isolated teratozoospermic men: a study with strictly controlled external factors and WHO-5 standard

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