Isolated Tachycardia Presenting After Pfizer-BioNTech COVID-19 Vaccination

Tate, Charles F.; Demashkieh, Luay; Hakmeh, Wael

doi:10.7759/cureus.16706

Cited by 7 publications

(10 citation statements)

References 8 publications

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“…Apart from inflammatory conditions (i.e. myocarditis and pericarditis) some rare cases of Takotsubo cardiomyopathy (stress‐induced cardiomyopathy), 56,61,69,70 MI, 61,66,71 MINOCA, 61 and isolated tachycardia 72 were also reported following immunisation with mRNA COVID‐19 vaccines. The median age of the four cases of Takotsubo cardiomyopathy were 61.5 years old, three of which were female.…”

Section: Resultsmentioning

confidence: 99%

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Fazlollahi

Zahmatyar

Noori

et al. 2021

Reviews in Medical Virology

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There have been several local and systemic adverse events associated with mRNA COVID-19 vaccines. Pericarditis, myocarditis and myocardial infarction are examples of cardiac complications related to these vaccines. In this article, we conducted a systematic review of case reports and case series to identify the clinical profile, investigations, and management of reported cardiac complications post-mRNA COVID-19 vaccines. We systematically searched PubMed, Scopus, Web of Science, and Google Scholar, as well as the medRxiv preprint server, with terms including: 'SARS-CoV-2', 'COVID-19', 'messenger RNA vaccine*', 'mRNA-1273 vaccine', 'BNT162 vaccine', 'myocarditis', 'pericarditis', 'stroke' and 'Myocardial Ischemia' up to 25 September 2021. Studies were excluded if they were not case reports or case series, or reported cases from non-mRNA vaccines. Case reports and case series were included that investigated the potential cardiac complications associated with mRNA COVID-19 vaccines. The JBI checklist was used to assess quality and data synthesis was conducted using a qualitative methodology called narrative synthesis. Sixty-nine studies, including 43 case reports and 26 case series, were included. Myocarditis/myopericarditis and pericarditis were the most common adverse events among the 243 reported cardiac complications, post mRNA COVID-19 vaccination. Males with a median age of 21 years had the highest frequency of myocarditis. Almost three quarters (74.4%) of cases with myocarditis had received the BNT162b2 vaccine and 87.7% had received the second dose of the vaccine.Chest pain (96.1%) and fever (38.2%) were the most common presentations. CK-MB, troponin, and NT-proBNP were elevated in 100%, 99.5% and 78.3% of subjects, respectively. ST-segment abnormality was the most common electrocardiogram feature. Cardiac magnetic resonance imaging, which is the gold-standard approach for diagnosing myocarditis, was abnormal in all patients diagnosed with

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Section: Resultsmentioning

confidence: 99%

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Fazlollahi

Zahmatyar

Noori

et al. 2021

Reviews in Medical Virology

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“…Three reports described tachycardia as a side effect of Pfizer-BioNTech COVID-19 vaccine [ 10 ]. However, supraventricular tachycardia was associated with vaccine use independently of age and gender [ 11 ]. Thus, cardiac arrhythmia can be a side effect of the COVID-19 vaccine.…”

Section: Discussionmentioning

confidence: 99%

Fetal Supraventricular Tachycardia and Maternal COVID-19 Vaccination: is There Any relationship?

et al. 2022

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Fetal supraventricular tachycardia accounts for 60–80% of the fetal tachyarrhythmias with prevalence ranging from 1/1000 to 1/25 000 pregnancies. It may be secondary to fetal anomalies or maternal factors. By reviewing the literature, there is no previous article that reports fetal arrhythmia after maternal vaccination. We present herein two cases of fetal supraventricular tachycardia following the administration of the Pfizer-BioNTech COVID-19 vaccine during pregnancy. Continued safety monitoring and more longitudinal follow-up are needed to evaluate the fetal impact after maternal COVID-19 vaccination.

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“…Tachycardia following COVID-19 vaccination is another well documented adverse event [ 10 , 122 ]. In more detail, cross reacting antibodies are proposed to target the nervous system, leading to postural orthostatic tachycardia (POTS).…”

Section: Introductionmentioning

confidence: 99%

COVID-19 vaccines adverse events: potential molecular mechanisms

et al. 2023

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COVID-19 is an infectious disease caused by a single-stranded RNA (ssRNA) virus, known as SARS-CoV-2. The disease, since its first outbreak in Wuhan, China, in December 2019, has led to a global pandemic. The pharmaceutical industry has developed several vaccines, of different vector technologies, against the virus. Of note, among these vaccines, seven have been fully approved by WHO. However, despite the benefits of COVID-19 vaccination, some rare adverse effects have been reported and have been associated with the use of the vaccines developed against SARS-CoV-2, especially those based on mRNA and non-replicating viral vector technology. Rare adverse events reported include allergic and anaphylactic reactions, thrombosis and thrombocytopenia, myocarditis, Bell’s palsy, transient myelitis, Guillen-Barre syndrome, recurrences of herpes-zoster, autoimmunity flares, epilepsy, and tachycardia. In this review, we discuss the potential molecular mechanisms leading to these rare adverse events of interest and we also attempt an association with the various vaccine components and platforms. A better understanding of the underlying mechanisms, according to which the vaccines cause side effects, in conjunction with the identification of the vaccine components and/or platforms that are responsible for these reactions, in terms of pharmacovigilance, could probably enable the improvement of future vaccines against COVID-19 and/or even other pathological conditions.

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Isolated Tachycardia Presenting After Pfizer-BioNTech COVID-19 Vaccination

Cited by 7 publications

References 8 publications

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Fetal Supraventricular Tachycardia and Maternal COVID-19 Vaccination: is There Any relationship?

COVID-19 vaccines adverse events: potential molecular mechanisms

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