Isolated soft tissue cleft lip: epidemiology and associated dental anomalies

Aizenbud, Dror; Coval, M; Hazan-Molina, Hagai; Harari, Doron

doi:10.1111/j.1601-0825.2010.01729.x

Cited by 18 publications

(20 citation statements)

References 37 publications

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“…found that dental anomalies increase with cleft severity (Stahl et al 2006;Letra et al 2007;Aizenbud et al 2011). Mutations in genes influencing both palatogenesis and dental development could also partly account for the greater prevalence of dental anomalies in individuals with clefts.…”

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confidence: 99%

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

et al. 2015

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Children with oral clefts show a wide range of dental anomalies, adding complexity to understanding the phenotypic spectrum of orofacial clefting. The evidence is mixed, however, on whether the prevalence of dental anomalies is elevated in unaffected relatives and is mostly based on small samples. In the largest international cohort to date of children with nonsyndromic clefts, their relatives, and controls, this study characterizes the spectrum of cleft-related dental anomalies and evaluates whether families with clefting have a significantly higher risk for such anomalies compared with the general population. A total of 3,811 individuals were included: 660 cases with clefts, 1,922 unaffected relatives, and 1,229 controls. Dental anomalies were identified from in-person dental exams or intraoral photographs, and case-control differences were tested using χ2 statistics. Cases had higher rates of dental anomalies in the maxillary arch than did controls for primary (21% vs. 4%, P = 3 × 10−8) and permanent dentitions (51% vs. 8%, P = 4 × 10−62) but not in the mandible. Dental anomalies were more prevalent in cleft lip with cleft palate than other cleft types. More anomalies were seen in the ipsilateral side of the cleft. Agenesis and tooth displacements were the most common dental anomalies found in case probands for primary and permanent dentitions. Compared with controls, unaffected siblings (10% vs. 2%, P = 0.003) and parents (13% vs. 7%, P = 0.001) showed a trend for increased anomalies of the maxillary permanent dentition. Yet, these differences were nonsignificant after multiple-testing correction, suggesting genetic heterogeneity in some families carrying susceptibility to both overt clefts and dental anomalies. Collectively, the findings suggest that most affected families do not have higher genetic risk for dental anomalies than the general population and that the higher prevalence of anomalies in cases is primarily a physical consequence of the cleft and surgical interventions.

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confidence: 99%

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

et al. 2015

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“…El labio fisurado ocurre en 1:1000 nacidos vivos, es más frecuente en el sexo masculino mientras que el paladar hendido se presenta en 1:2500 nacidos vivos, más usual en mujeres. 5 La mayoría de las veces se presenta en forma conjunta la presencia de labio y paladar. En Colombia, su prevalencia es de 1,54 por cada 1000 nacidos vivos.…”

Section: Introductionunclassified

Factores Ambientales Asociados Con Labio O Paladar Hendido No Sindrómico en Una Población Del Magdalena Medio Colombiano

et al. 2014

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RESUMENObjetivo: evaluar la posible asociación entre factores ambientales y la presencia de labio o paladar hendido (LPH) no sindrómico en los niños residentes en el Magdalena Medio colombiano.Materiales y métodos: se realizó un estudio de casos y controles con 30 madres de niños con LPH (casos) y 60 madres de niños sin alguna alteración craneofacial (controles). Los casos y controles se obtuvieron de una clínica dental en la región mencionada. Las variables analizadas fueron las sociodemográficas (edad, condición socioeconómica, nivel de escolaridad, lugar de residencia antes y durante el primer trimestre); las relacionadas con la gestación (exposición a pesticidas, consumo prenatal de sustancias psicoactivas, alcohol y tabaco), la presencia de LPH en la familia. Se aplicó la prueba de Chi 2 o test Exacto de Fisher según fuera apropiado, la t de Student o U. de Mann Whitnney de acuerdo con la distribución de las variables. Se realizó una regresión logística para establecer los Odds Ratio (OR) crudos y ajustados. ENVIRONMENTAL FACTORS ASSOCIATED WITH ORAL CLEFTS IN CHILDREN LIVING IN COLOMBIAN MAGDALENA MEDIOABSTRACT Objective: to assess the possible association between environmental factors and the presence of non-syndromic cleft lip and/or palate (CL/P) in children living in the Colombian Magdalena Medio.Methods: a case-control study was carried out with 30 mothers of children with CL/P (cases) and 60 mothers of children without any craniofacial alteration (controls). The cases and controls were obtained from a dental clinic in the region mentioned. The variables analyzed were sociodemographic (age, socioeconomic condition, educational level, place of residence before and during the first trimester); pregnancy background (prenatal examinations, diseases, drugs, alcohol and tobacco consumption, psychoactive substances consumption and pesticide exposure), presence of CL/P in the family. Chi-square and Fisher Exact test, Student t test or U Mann Whitney were performed when appropriate. A logistic regression was done to establish the crude and adjusted odds ratio (OR). Conclusions: exposure to pesticides and the presence of CL/P in the family of the affected child increased the risk for non-syndromic oral clefts. Results

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“…Os indivíduos com fissuras labiopalatinas, além de grave problema estético, apresentam distúrbios funcionais severos, de forma que, se esta deformidade não for tratada incidência de anomalias dentárias do que indivíduos sem fissuras e ainda, que a gravidade das anomalias dentárias parece estar relacionada à gravidade das fissuras labiopalatinas, principalmente quando se trata de fissura de lábio isolada (Adams e Niswander 1967, Schroeder e Green 1975, Larson et al 1998, Eerens et al 2001, Stahl et al 2006, Aizenbud et al 2010). …”

Section: Fissura Labiopalatinaunclassified

“…Enquanto essas malformações são comumente causadas por defeitos em genes específicos, eventos etiológicos pré e pós-natal também têm resultado em malformações no tamanho, morfologia, posição, número e forma dos dentes (Aizenbud et al 2010). …”

Section: Malformações Dentáriasunclassified

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Estudo genético da mutação do gene AMELX na malformação dentária de pacientes com e sem fissura labiopalatina

Oliveira¹

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Isolated soft tissue cleft lip: epidemiology and associated dental anomalies

Abstract: Isolated cleft lip is a rare phenomenon among the spectrum of the cleft-affected population. The prevalence of the dental anomalies in ICL maintains the proportional trend according to clefting severity.

Cited by 18 publications

References 37 publications

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

Spectrum of Dental Phenotypes in Nonsyndromic Orofacial Clefting

Factores Ambientales Asociados Con Labio O Paladar Hendido No Sindrómico en Una Población Del Magdalena Medio Colombiano

Estudo genético da mutação do gene AMELX na malformação dentária de pacientes com e sem fissura labiopalatina

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