Isolated single umbilical artery: need for specialist fetal echocardiography?

Defigueiredo, D.; Dagklis, Themistoklis; Zidere, Vita; Allan, Lindsey D.; Nicolaides, Kypros H.

doi:10.1002/uog.7711

Cited by 31 publications

(38 citation statements)

References 31 publications

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“…In several studies, the prevalence of fetal abnormalities associated with single umbilical artery is 33.6% [14]. Interestingly, this particularity was present in our case and in the case by Olsen and al., because of the very small number of cases and the non specific character of a single umbilical artery, we believe this is more of an anecdotical finding than an associated sign.…”

Section: Discussionsupporting

confidence: 67%

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Antenatal Diagnosis of Isolated Total Arhinia in the Second Trimester of Pregnancy

D¹,

Slachmuylder²,

Popijn³

et al. 2016

OJOG

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Congenital arhinia is a very rare condition especially when it is isolated. Most of arhinia are identified after birth and only five prenatal cases are described in the literature. Generally, arhinia is associated with other malformations mainly craniofacial anomalies. Genetics aberrations are uncommon. Our case was diagnosed in the second trimester of pregnancy and we found no associated anomaly except for a single umbilical artery. Autopsy confirmed the diagnosis and neuropathology analysis revealed the absence of olfactory bulbs and tracts.

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Section: Discussionsupporting

confidence: 67%

“…Some authors have identified cases of arhinia with hypogonadotropic hypogonadism, but no genetic loci were found to explain this association [12]- [14].…”

Section: Discussionmentioning

confidence: 99%

Antenatal Diagnosis of Isolated Total Arhinia in the Second Trimester of Pregnancy

D¹,

Slachmuylder²,

Popijn³

et al. 2016

OJOG

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“…Sixty‐eight of the 74 fetuses had a normal 4‐chamber view of the heart before echocardiography. In 2010, Defigueiredo and colleagues showed that from the 16 cardiac defects diagnosed in 246 cases of a single umbilical artery, 10 defects were in a subgroup of 233 pregnancies with no other extracardiac defects. Only 3 defects, 2 ventricular septal defects and a left superior vena cava, were diagnosed by a “specialist.” The other defects were readily diagnosed by evaluating the standard views of the 4‐chamber heart and the great arteries.…”

Section: Discussionmentioning

confidence: 99%

Isolated Single Umbilical Artery and Fetal Echocardiography: A 25‐Year Experience at a Tertiary Care City Hospital

Gurram

Figueroa

Sipusic

et al. 2017

J of Ultrasound Medicine

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“…Some studies have demonstrated that in the presence of SUA and a normal four-chamber cardiac Correspondence: F. Costa, Pregnancy Research Centre, Department of Perinatal Medicine, Th e Royal Women ' s Hospital, 20 Flemington Road, Parkville, Victoria 3052, Australia. E-mail: fabricio.costa@thewomens.org.au view, it is not necessary to refer pregnant women for specialist fetal echocardiography (Gosset et al 2002;DeFigueiredo et al 2010). In contrast, other studies have shown a signifi cant relationship between CHD and the presence of SUA on the 2nd trimester ultrasound, and these studies recommend that the presence of SUA should be considered an indication for fetal echocardiography (Li et al 2008;Hua et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Congenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery

Júnior

Palma-Dias

Martins³

et al. 2014

J Obstet Gynaecol

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To examine the association between isolated single umbilical artery (SUA) and congenital heart disease/adverse perinatal outcome in an Australian tertiary centre. The study population was comprised of fetuses diagnosed with SUA at the mid-trimester scan between May 2003 and March 2009 during detailed ultrasound examination at The Royal Women's Hospital Melbourne, Australia. Colour Doppler was used to visualise the umbilical arteries adjacent to the fetal bladder and in a section of a free loop of cord. The diagnosis of SUA was confirmed on histopathology examination of the placenta and umbilical cord. Monochorionic twins, fetuses with chromosomal abnormalities or concurrent extracardiac anomalies were excluded from the study. A total of 261 fetuses with SUA were identified in the study period and 146 (59%) cases were isolated; no chromosomal or extracardiac abnormalities were present. Complete data were available in 104/146 pregnancies (71.2%). The mean gestational age at diagnosis was 21 weeks. A cardiac anomaly was detected in 19 of these fetuses (13.0%): six hypoplastic left heart syndromes; three coarctations of the aorta; two tetralogies of Fallot; two hypoplastic right heart syndromes; two pulmonary atresia/stenosis; one absent ductus venosus with cardiomegaly; one left isomerism; one right isomerism and one transposition of the great arteries. Fetal growth restriction was present in 9.8% (10) and preterm delivery before 34 weeks occurred in nine cases (8.7%). Our study has shown that isolated SUA is associated with cardiac anomalies, but is not associated with increased frequency of FGR and preterm delivery before 34 weeks.

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Isolated single umbilical artery: need for specialist fetal echocardiography?

Abstract: Objective To examine the association between single umbilical artery (SUA)

Cited by 31 publications

References 31 publications

Antenatal Diagnosis of Isolated Total Arhinia in the Second Trimester of Pregnancy

Antenatal Diagnosis of Isolated Total Arhinia in the Second Trimester of Pregnancy

Isolated Single Umbilical Artery and Fetal Echocardiography: A 25‐Year Experience at a Tertiary Care City Hospital

Congenital heart disease and adverse perinatal outcome in fetuses with confirmed isolated single functioning umbilical artery

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