Isolated single umbilical artery and fetal karyotype

Dagklis, Themistoklis; Defigueiredo, D.; Staboulidou, I.; Casagrandi, D.; Nicolaides, Kypros H.

doi:10.1002/uog.7717

Cited by 54 publications

(36 citation statements)

References 24 publications

(40 reference statements)

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“…Fetuses with a SUA are considered at increased risk of chromosomal and structural abnormalities [178910]. Therefore, when SUA is diagnosed at the time of the mid-trimester scan, targeted ultrasound is warranted to rule out underlying pathologic conditions.…”

Section: Introductionmentioning

confidence: 99%

Association of isolated single umbilical artery with perinatal outcomes: Systemic review and meta-analysis

Kim

Chay

et al. 2017

Obstet Gynecol Sci

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ObjectiveThe aim of this study was to evaluate the association between prenatally diagnosed isolated single umbilical artery (iSUA) and perinatal outcomes.MethodsWe searched Medline, Embase, the Cochrane Library, and KoreaMed from inception to January 2016, with no language or regional restrictions, for cohort and case-control studies reporting on the relationship of iSUA and perinatal outcomes. We assessed the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission, and perinatal mortality in fetuses with iSUA compared with those in fetuses with three vessel cord.ResultsEleven articles totaling 1,731 pregnancies with iSUA met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that the presence of an iSUA was associated with small for gestational age (OR, 2.75; 95% CI, 1.97 to 3.83; P<0.00001), preterm birth (OR, 2.10; 95% CI, 1.72 to 2.57; P<0.00001), pregnancy-induced hypertension (OR, 1.62; 95% CI, 1.00 to 2.63; P=0.05), neonatal intensive care unit admission (OR, 2.06; 95% CI, 1.33 to 3.19; P=0.001), and perinatal mortality (OR, 2.29; 95% CI, 1.32 to 3.98; P=0.003).ConclusionPregnancies complicated by iSUA are at increased risk for small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission and perinatal mortality. Further, large prospective cohort studies are required to improve the quality of prenatal counseling and the neonatal care for pregnancies with iSUA.

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Section: Introductionmentioning

confidence: 99%

Association of isolated single umbilical artery with perinatal outcomes: Systemic review and meta-analysis

Kim

Chay

et al. 2017

Obstet Gynecol Sci

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“…Single umbilical artery (SUA), the most common anatomical abnormality of the umbilical cord, is found in 0.2–1.1% of singleton pregnancies and is associated with structural and chromosomal abnormalities, with placental anomalies and with anomalies of umbilical cord insertion1–3. Moreover, a higher prevalence of intrauterine growth restriction has been consistently reported in fetuses with SUA owing to an increased incidence of placental insufficiency2, 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Single umbilical artery in twin pregnancies

Klatt

Kühn

Baumann

et al. 2012

Ultrasound in Obstet & Gyne

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“…Its presence is associated with additional fetal structural anomalies and aneuploidy. In a large series from a single referral center, 4 the incidence of chromosomal anomalies associated with a single umbilical artery was 5.2% when one major defect was present and 50.7% when multiple defects were observed. In 424 cases of an isolated single umbilical artery, no cases of aneuploidy were detected.…”

Section: Discussionmentioning

confidence: 96%

“…In 424 cases of an isolated single umbilical artery, no cases of aneuploidy were detected. In a review of the literature, 4 the incidence of aneuploidy, most commonly trisomies 13, 18, and 21, in the presence of a single umbilical artery, isolated or not, was estimated to be 9.6%. In the presence of an isolated single umbilical artery, the incidence was 6 per 809 (0.7%).…”

Section: Discussionmentioning

confidence: 99%

Omega-Shaped Variant of the Umbilical Artery

Shen

Rabinowitz

Malinger

et al. 2013

Journal of Ultrasound in Medicine

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The purpose of this series was to report on the observation of an anomalous course of the umbilical artery. Ten cases in a 25‐month period are reported. An omega‐shaped variant, coined the “omega sign,” of one of two umbilical arteries or of a single umbilical artery was observed. In 2 cases, there were two umbilical arteries, one of them with the anomalous vessel. In 8 cases, the vessel was a single umbilical artery. In 1 case with a single umbilical artery and pericardial effusion, aneuploidy was found on amniocentesis. A second case was associated with multiple anomalies. A third case was associated with hypoplastic left heart syndrome. Seven cases with the omega sign as an isolated finding, with or without a single umbilical artery, had favorable outcomes. An omega‐shaped variant of the umbilical artery is likely to be more common in cases of a single umbilical artery than in cases with two umbilical arteries. It is probably a normal variant when unassociated with additional sonographically detectable structural anomalies.

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Isolated single umbilical artery and fetal karyotype

Abstract: ABSTRACT

Cited by 54 publications

References 24 publications

Association of isolated single umbilical artery with perinatal outcomes: Systemic review and meta-analysis

Association of isolated single umbilical artery with perinatal outcomes: Systemic review and meta-analysis

Single umbilical artery in twin pregnancies

Omega-Shaped Variant of the Umbilical Artery

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